Pulmonary Gas Exchange Quiz

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Questions and Answers

What primarily drives the movement of gases from the alveoli into the blood?

  • Temperature gradients
  • Solubility in blood
  • Concentration gradients (correct)
  • Electrochemical gradients

Which gas constitutes approximately 21% of the Earth's atmosphere?

  • Oxygen (correct)
  • Nitrogen
  • Hydrogen
  • Carbon Dioxide

At sea level, what is the standard atmospheric pressure in mm Hg?

  • 253 mm Hg
  • 760 mm Hg (correct)
  • 500 mm Hg
  • 600 mm Hg

What is the partial pressure of nitrogen (PN2) in the atmosphere at sea level?

<p>600 mm Hg (B)</p> Signup and view all the answers

During inhalation, what is the first process that affects the inhaled air?

<p>Humidification of air (A)</p> Signup and view all the answers

Which of the following statements is true about the partial pressures of gases at sea level?

<p>PO2 equals 160 mm Hg. (B)</p> Signup and view all the answers

What is the relationship between total atmospheric pressure and the partial pressure of a gas?

<p>Total pressure equals the sum of partial pressures of individual gases. (D)</p> Signup and view all the answers

What happens to gas molecules in terms of pressure during gas exchange?

<p>They move from high pressure to low pressure areas. (A)</p> Signup and view all the answers

What is the primary reason carbon dioxide can diffuse across the alveolar capillary despite having a lower driving force compared to oxygen?

<p>It possesses a greater diffusion coefficient. (B)</p> Signup and view all the answers

During rest, what is the approximate volume of oxygen that needs to enter the capillary per 100 ml of blood?

<p>5 ml (B)</p> Signup and view all the answers

How much time is required for oxygen equilibration in the capillary under resting conditions?

<p>One-third the length of the capillary (A)</p> Signup and view all the answers

What happens to the oxygen saturation of blood during strenuous exercise?

<p>It can be less than 100% saturated. (B)</p> Signup and view all the answers

What is the driving force for oxygen diffusion across the alveolar capillary at rest?

<p>64 mm Hg (B)</p> Signup and view all the answers

Which factor contributes most to the enhanced oxygen demand during strenuous exercise?

<p>Increased cardiac output (C)</p> Signup and view all the answers

In the context of gas exchange, which of the following statements is true regarding the safety margin?

<p>It allows for adequate oxygen equilibration even with increased blood flow. (D)</p> Signup and view all the answers

What does the difference in partial pressures (ΔP) for carbon dioxide indicate?

<p>It is significantly less than the difference for oxygen. (B)</p> Signup and view all the answers

What phenomenon refers to the increased bicarbonate levels and decreased chloride levels in venous blood?

<p>Chloride shift (C)</p> Signup and view all the answers

What is the partial pressure of oxygen (PO2) at the arterial end of the pulmonary capillaries?

<p>104 mm Hg (B)</p> Signup and view all the answers

What is the primary factor that allows carbon dioxide to diffuse readily from cells into the interstitium?

<p>Lower pressure gradient compared to oxygen (C)</p> Signup and view all the answers

What happens to venous PCO2 levels if carbonic anhydrase is inhibited?

<p>They rise dramatically to 80 mm Hg (B)</p> Signup and view all the answers

At rest, how much oxygen do the tissues of the body require per minute?

<p>250 ml (D)</p> Signup and view all the answers

What is the percentage of oxygen saturation of hemoglobin at a partial pressure of oxygen of 40 mm Hg in venous blood?

<p>75% (A)</p> Signup and view all the answers

What is the venous end partial pressure of carbon dioxide (PCO2) when entering the alveolar capillary?

<p>45 mm Hg (C)</p> Signup and view all the answers

In venous blood, what form does the majority of carbon dioxide take as it is transported to the lungs?

<p>As bicarbonate (HCO3-) (D)</p> Signup and view all the answers

What is the partial pressure of oxygen (PO2) in systemic arterial blood compared to venous blood?

<p>Higher by 55 mm Hg (C)</p> Signup and view all the answers

If the partial pressure of oxygen (PO2) is 40 mm Hg, how much oxygen is dissolved in every deciliter of blood?

<p>0.12 ml (B)</p> Signup and view all the answers

What equation would yield the amount of oxygen deliverable if only dissolved oxygen was transported in blood?

<p>(0.29 – 0.12)(Cardiac Output = 5 L/min) (D)</p> Signup and view all the answers

What is the concentration of carbon dioxide dissolved in venous blood compared to bicarbonate?

<p>Higher than both bicarbonate and bound CO2 (D)</p> Signup and view all the answers

What is the overall intracellular partial pressure of carbon dioxide (PCO2)?

<p>46 mm Hg (B)</p> Signup and view all the answers

What is the driving pressure forcing oxygen into plasma at the arterial end of a pulmonary capillary?

<p>64 mm Hg (B)</p> Signup and view all the answers

What is the difference in the dissolved oxygen amounts at PO2 levels of 95 mm Hg and 40 mm Hg?

<p>0.17 ml (B)</p> Signup and view all the answers

What percentage of carbon dioxide is transported in blood as CO2 in solution?

<p>7% (B)</p> Signup and view all the answers

What percentage of oxygen delivery to tissues occurs in the form of free solution?

<p>3% (B)</p> Signup and view all the answers

How much oxygen can each gram of hemoglobin bind?

<p>1.34 ml (C)</p> Signup and view all the answers

At a partial pressure of 95 mm Hg, what is the saturation percentage of hemoglobin with oxygen?

<p>97% (A)</p> Signup and view all the answers

What is the total potential oxygen output to circulation each minute at a resting cardiac output of 5 L/min?

<p>1000 ml/min (D)</p> Signup and view all the answers

What is the amount of oxygen consumed per minute by the tissues at a partial pressure of 40 mm Hg?

<p>5 ml/deciliter (D)</p> Signup and view all the answers

What is the relationship between hemoglobin saturation and oxygen partial pressure when the P O2 falls to 40 mm Hg?

<p>Hemoglobin saturation decreases to 75% (D)</p> Signup and view all the answers

What is the calculated amount of oxygen delivered to the tissues at rest?

<p>213 ml/min (D)</p> Signup and view all the answers

What percentage of oxygen in the blood is contributed by free solution when cardiac output is at rest?

<p>3% (A)</p> Signup and view all the answers

What physiological change occurs to optimize oxygen uptake in the lungs due to the Bohr Effect?

<p>Decreased PCO2 and increased pH shift the hemoglobin dissociation curve to the left. (D)</p> Signup and view all the answers

Which factor does NOT contribute to shifting the hemoglobin dissociation curve to the left?

<p>Increased blood acidity (B)</p> Signup and view all the answers

What percentage of carbon dioxide is carried in blood as bicarbonate (HCO3-)?

<p>70% (A)</p> Signup and view all the answers

Why is fetal hemoglobin more effective than adult hemoglobin in extracting oxygen from maternal circulation?

<p>Fetal hemoglobin binds oxygen more tightly. (A)</p> Signup and view all the answers

What occurs to the hemoglobin dissociation curve when oxygenated blood reaches systemic capillaries?

<p>It shifts to the right, promoting oxygen off-loading. (D)</p> Signup and view all the answers

Which condition would likely cause hypocapnia, affecting the oxygen dissociation curve?

<p>Hyperventilation (D)</p> Signup and view all the answers

How much carbon dioxide must be transported from the tissues to the lungs per 100 ml of blood?

<p>4 ml (B)</p> Signup and view all the answers

What is the primary reason fetal hemoglobin does not release its oxygen as readily?

<p>Increased affinity for oxygen (A)</p> Signup and view all the answers

Flashcards

Partial Pressure of a Gas

The pressure exerted by a particular gas in a mixture of gases.

Atmospheric Pressure

The pressure exerted by the weight of the atmosphere.

Partial Pressure of Oxygen (PO2)

The pressure exerted by oxygen in the air or a liquid.

Gas Movement

Gases move from areas of high partial pressure to areas of low partial pressure.

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Calculating Partial Pressure

Multiplying the fraction of a gas in a mixture by the total pressure.

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Gas Exchange (Lungs)

Oxygen moves from the alveoli to the blood; Carbon dioxide moves from blood to alveoli.

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Humidification

Adding water vapor to inhaled air.

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Partial Pressure of Nitrogen (PN2)

The pressure exerted by nitrogen in the atmosphere.

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Chloride Shift

A process in venous blood where bicarbonate moves out of red blood cells into plasma, causing a drop in plasma chloride levels.

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Carbon Dioxide Transport

Majority of CO2 transported in the blood as bicarbonate (HCO3-).

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Venous Blood PCO2

Venous blood partial pressure of CO2 is around 45 mm Hg.

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Venous Oxygen Saturation

Hemoglobin in venous blood is about 75% saturated with oxygen.

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Oxygen Partial Pressure in Venous Blood

The partial pressure of oxygen in venous blood is 40 mm Hg.

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Pulmonary Capillary Gas Exchange

Oxygen moves from the alveoli into the blood due to the pressure difference.

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Carbonic Anhydrase Inhibition

Inhibiting carbonic anhydrase raises venous PCO2 levels significantly.

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Oxygen in Venous Blood

Oxygen in venous blood is carried in solution and bound to hemoglobin.

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Alveolar-Capillary Equilibration

The process where the partial pressure of oxygen (PO2) and carbon dioxide (PCO2) in the blood equilibrate with the PO2 and PCO2 in the alveoli.

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Safety Factor in Gas Exchange

The fact that gas exchange, especially oxygen, reaches equilibrium within 1/3rd of the capillary transit time, allowing for efficient exchange even with increased blood flow.

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Diffusion Coefficient

A measure of how easily a gas can move through a membrane. Carbon dioxide has a higher diffusion coefficient than oxygen.

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Driving Force for Gas Diffusion

The difference in partial pressure between two areas. A larger difference results in faster diffusion.

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Carbon Dioxide Diffusion

Carbon dioxide diffuses from the blood into the alveoli, despite a smaller pressure gradient compared to oxygen.

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Exercise and Gas Exchange

During exercise, increased cardiac output reduces capillary transit time. However, the safety factor ensures efficient oxygen uptake.

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Oxygen Saturation

The percentage of hemoglobin molecules in the blood carrying oxygen.

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Cardiac Output

The amount of blood pumped by the heart per minute.

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Systemic Venous PO2

The partial pressure of oxygen in blood entering the systemic veins, typically around 40 mm Hg.

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Alveolar PO2

The partial pressure of oxygen in the alveoli of the lungs, typically around 104 mm Hg.

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Mitochondrial CO2 Production

The primary site of carbon dioxide production in cells, where it is generated during metabolism.

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Interstitial CO2

The partial pressure of carbon dioxide in the interstitial fluid surrounding cells, typically around 45 mm Hg.

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Systemic Venous PCO2

The partial pressure of carbon dioxide in blood entering the systemic veins, typically around 45 mm Hg.

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Alveolar PCO2

The partial pressure of carbon dioxide in the alveoli of the lungs, typically around 40 mm Hg.

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Oxygen Transport in Blood

The mechanism by which oxygen is carried from the lungs to the tissues. Mainly bound to hemoglobin but a small amount is dissolved directly in plasma.

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Resting Oxygen Demand

The amount of oxygen required by the body's tissues at rest, typically about 250 ml per minute.

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Hemoglobin saturation

The percentage of hemoglobin molecules that are bound to oxygen. This saturation is affected by the partial pressure of oxygen (PO2).

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Hemoglobin dissociation curve

A graphical representation of the relationship between hemoglobin saturation and the partial pressure of oxygen (PO2). It demonstrates the allosteric binding of oxygen to hemoglobin.

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Allosteric binding of oxygen

Hemoglobin's ability to bind oxygen is influenced by changes in its shape, which is triggered by factors like PO2 and pH.

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Oxygen offloading at tissues

Hemoglobin releases oxygen in the systemic capillaries where the partial pressure of oxygen is lower. Only a fraction of the bound oxygen is released.

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Oxygen delivery at rest

At rest, the body requires about 250 ml/min of oxygen. Hemoglobin's oxygen binding capacity allows for more than enough oxygen delivery, even at rest.

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Oxygen delivery during exercise

During exercise, the body's oxygen demand increases significantly. Cardiac output increases to deliver more blood containing oxygen.

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Oxygen contribution of free solution

Only a small percentage (about 3%) of the total oxygen delivered to tissues is transported as free solution. Most oxygen is transported bound to hemoglobin.

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Bohr Effect

The shift in the oxygen-hemoglobin dissociation curve due to changes in blood pH and PCO2, optimizing oxygen loading in the lungs and unloading in tissues.

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Left Shift in Dissociation Curve

Occurs when blood pH increases (more alkaline) or PCO2 decreases, resulting in tighter oxygen binding to hemoglobin.

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Right Shift in Dissociation Curve

Occurs when blood pH decreases (more acidic) or PCO2 increases, resulting in easier oxygen release from hemoglobin.

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Fetal Hemoglobin

Hemoglobin in fetal blood with a higher affinity for oxygen than adult hemoglobin, allowing the fetus to extract oxygen from the maternal circulation.

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Bicarbonate (HCO3-)

The major form of carbon dioxide transported in the blood, formed by the reaction of carbon dioxide with water.

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Carbaminohemoglobin

Hemoglobin bound to carbon dioxide, contributing to carbon dioxide transport.

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Carbon Dioxide Excretion

The process of removing carbon dioxide from the body via exhalation, primarily through the lungs.

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Study Notes

Pulmonary Gas Exchange

  • Gas exchange occurs between blood and alveoli.
  • Oxygen moves from alveoli to blood.
  • Carbon dioxide moves from blood to alveoli.

Gas Partial Pressures

  • Gases move from high pressure to low pressure.
  • Partial pressure is used to compare gas concentration between compartments.
  • Atmospheric pressure is the weight of the air column above us.
  • Partial pressure of nitrogen in atmosphere = 600 mm Hg
  • Partial pressure of oxygen in atmosphere = 160 mm Hg

Humidification of Inhaled Air

  • Inhaling humidifies air.
  • Atmospheric pressure stays constant (760 mm Hg)
  • Water vapor partial pressure = 47 mm Hg.
  • This reduces partial pressure of oxygen and nitrogen.
  • Inhaled Air P02 = 150 mm Hg
  • Inhaled Air PN2 = 563 mm Hg

Tidal Volume and Alveolar Air

  • Tidal volume is the air inhaled in one breath.
  • Only a portion of tidal volume reaches alveoli.
  • Air in alveoli mixes with air from previous breath.
  • Partial pressures of nitrogen, oxygen, carbon dioxide, and water vapor differ in various locations.

Gas Exchange in Pulmonary Capillaries

  • At beginning of capillary, P02 is 40 mm Hg and PCO2 is 46 mm Hg.
  • 1/3rd the length of a capillary is for oxygen equilibration.
  • P02 = 104 mm Hg; PCO2 = 40 mm Hg.

Factors that cause fast oxygen and CO2 exchange

  • Oxygen equilibrates quicker.
  • CO2 has faster diffusion coefficient than oxygen.
  • Therefore there is a 20-fold greater diffusion coefficient for carbon dioxide.

Oxygen Transport in the Blood

  • 97% of oxygen transported bound to hemoglobin
  • At rest, tissues require 250 ml of oxygen/min
  • Dissolved oxygen is insufficient.
  • Hemoglobin carries the rest of the oxygen needed.

Factors that shift the oxygen-hemoglobin dissociation curve to the right.

  • Increased blood acidity (lower pH)
  • Increased blood PCO2
  • Increased blood 2,3-DPG
  • Increased body temperature

Factors that shift the oxygen-hemoglobin dissociation curve to the left

  • Decreased blood acidity (higher pH)
  • Decreased blood PCO2

Carbon Dioxide Transport in the Blood

  • 70% of carbon dioxide is bicarbonate (HCO3−)
  • 23% bound to hemoglobin (carbaminohemoglobin)
  • 7% in free solution
  • 4 ml CO2/100 ml of blood must be removed

Haldane Effect

  • Increased oxygen binding decreases haemoglobin affinity for carbon dioxide.

Bohr Effect

  • Low pH and high PCO2 cause a right shift in the oxygen-hemoglobin dissociation curve.

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