Pediatric Pulm
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Pediatric Pulm

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Questions and Answers

Which of the following is the most appropriate intervention?

  • Acetaminophen
  • Doxycycline
  • Ceftriaxone (correct)
  • Erythromycin
  • Rifampin
  • Which of the following best describes the laboratory evaluation of a patient diagnosed with acute myeloid leukemia?

  • Elevated WBC > 10,000, Philadelphia chromosome
  • Pancytopenia & hairy cells
  • Pancytopenia with circulating blasts and presence of Auer rods (correct)
  • Isolated lymphocytosis, lymphocytes appear small & immature
  • A 20-year-old woman complains of easy fatigability. What is the most likely diagnosis based on the physical examination?

  • Atrial septal defect (correct)
  • Tricuspid regurgitation
  • Mitral regurgitation
  • Aortic stenosis
  • Ventricular septal defect
  • What are the presentations for which a comprehensive differential diagnosis should be established?

    <p>Cough, dyspnea, hypoxemia, sputum production, hemoptysis, and clubbing.</p> Signup and view all the answers

    Which of the following is NOT a reason for a chest x-ray (CXR) interpretation?

    <p>Evaluate for allergies</p> Signup and view all the answers

    What is the method of obtaining Arterial Blood Gases (ABGs)?

    <p>A blood sample is taken from an artery.</p> Signup and view all the answers

    Define acidosis in relation to arterial blood gas findings.

    <p>Acidosis is a condition characterized by low pH, indicating excess hydrogen ions or inadequate bicarbonate in the body.</p> Signup and view all the answers

    Which acid-base disorder is most likely for a patient with these ABG results: pH 7.22, PaCO2 33, HCO3 16?

    <p>Metabolic acidosis</p> Signup and view all the answers

    What is the main cause of upper respiratory tract infection (URI) in children?

    <p>Rhinovirus.</p> Signup and view all the answers

    RSV stands for _____

    <p>Respiratory Syncytial Virus</p> Signup and view all the answers

    Match the following diagnostics to their indications:

    <p>CXR = Exclude pneumonia PFT = Assessment for chronic cough CT Scan = Cancer diagnosis and staging Bronchoscopy = View respiratory tract and take samples</p> Signup and view all the answers

    D-dimer is used to exclude the diagnosis of pulmonary embolism (PE).

    <p>True</p> Signup and view all the answers

    When is pulmonary function testing (PFT) contraindicated?

    <p>During any acute event such as myocardial infarction (MI) or active tuberculosis (TB).</p> Signup and view all the answers

    What are the common symptoms of pneumonia?

    <p>All of the above</p> Signup and view all the answers

    What can cause blunting of the costophrenic angles on a chest X-ray?

    <p>Pleural effusion</p> Signup and view all the answers

    Which condition is associated with widening of the mediastinum?

    <p>Aortic dissection</p> Signup and view all the answers

    What finding on a chest X-ray is likely to signify a significant pulmonary infiltrate?

    <p>Loss of heart border</p> Signup and view all the answers

    What is the most likely presentation in a patient who has aspirated a foreign body?

    <p>Fever, cough, stridor, and hemoptysis</p> Signup and view all the answers

    What is the main characteristic of pleural effusion on a chest X-ray?

    <p>Fluid accumulation between pleural layers</p> Signup and view all the answers

    What should be checked to evaluate for the presence of foreign bodies on a chest X-ray?

    <p>Surgical markings and lines</p> Signup and view all the answers

    Which of the following findings is most indicative of potential Lyme disease after a tick bite?

    <p>A skin lesion with central clearing and fever</p> Signup and view all the answers

    In assessing the great vessels on a chest X-ray, what condition could indicate abnormal findings?

    <p>Aortic size and shape</p> Signup and view all the answers

    What laboratory finding is most commonly associated with acute myeloid leukemia?

    <p>Circulating blasts and the presence of Auer rods</p> Signup and view all the answers

    Which evaluation technique is employed to check for infiltrates and masses on a chest X-ray?

    <p>Lateral film review</p> Signup and view all the answers

    In a patient exhibiting a fixed split second heart sound and a systolic ejection murmur, which condition is most likely responsible?

    <p>Atrial septal defect</p> Signup and view all the answers

    Which condition is characterized by significant bleeding alongside a low platelet count and various cell precursors in the bloodstream?

    <p>Disseminated intravascular coagulation (DIC)</p> Signup and view all the answers

    What is the purpose of checking the position of the gastric bubble on a chest X-ray?

    <p>To assess for diaphragmatic hernia</p> Signup and view all the answers

    Which group of patients requires admission for bronchiolitis treatment?

    <p>High risk infants with apnea or hypoxemia</p> Signup and view all the answers

    What is the most common bacterial cause of pneumonia in children?

    <p>Streptococcus pneumoniae</p> Signup and view all the answers

    Which of the following symptoms is indicative of pneumonia in an infant?

    <p>Apnea</p> Signup and view all the answers

    In diagnosing pneumonia, elevated white blood cell count (WBC) can assist in identifying what aspect?

    <p>Viral vs. bacterial infection type</p> Signup and view all the answers

    What might be a limiting factor for performing a chest X-ray in outpatient children suspected of pneumonia?

    <p>Concern over radiation exposure</p> Signup and view all the answers

    What is the initial treatment approach for a patient with pneumonia who shows hypoxemia?

    <p>Admission and aggressive hydration</p> Signup and view all the answers

    Which age group is most commonly affected by foreign body aspiration?

    <p>Toddlers under 3 years</p> Signup and view all the answers

    What do crackles and rhonchi on auscultation typically indicate in pneumonia patients?

    <p>Lung consolidation</p> Signup and view all the answers

    Which diagnostic method is mainly avoided in children with suspected pneumonia due to its invasiveness?

    <p>Bronchoscopy</p> Signup and view all the answers

    What is the primary indication for performing pulmonary function tests (PFTs)?

    <p>Assessment of drug efficacy</p> Signup and view all the answers

    In what scenario would a patient with pneumonia likely receive antibiotics?

    <p>When presenting with significant respiratory distress</p> Signup and view all the answers

    Which result from a PFT indicates the presence of obstructive lung disease?

    <p>Decreased FEV1 and decreased FVC</p> Signup and view all the answers

    What is the primary purpose of a CT scan's Hounsfield Units?

    <p>To convert radiation into density data</p> Signup and view all the answers

    In which scenario are pulmonary function tests (PFTs) contraindicated?

    <p>Active tuberculosis</p> Signup and view all the answers

    What characteristic of a CT scan allows for viewing small structures?

    <p>Slice thickness of 1mm</p> Signup and view all the answers

    What role do CT windows play in CT imaging?

    <p>They optimize the appearance of the image</p> Signup and view all the answers

    Forced vital capacity (FVC) measurements primarily help diagnose which types of lung diseases?

    <p>Both restrictive and obstructive lung diseases</p> Signup and view all the answers

    What is the primary imaging technique for assessing lung vascular occlusions?

    <p>CT scan</p> Signup and view all the answers

    Which of the following is not a common complication associated with pulmonary function testing?

    <p>Potential for increased cough severity</p> Signup and view all the answers

    What distinguishes a spiral or helical CT scan from a conventional CT scan?

    <p>It captures images in multiple planes simultaneously</p> Signup and view all the answers

    What is a potential complication when using D-dimer testing?

    <p>Inappropriate escalation of imaging based on positive results</p> Signup and view all the answers

    What is the primary use of a VQ scan in pulmonary diagnostics?

    <p>To assess ventilation and perfusion mismatch</p> Signup and view all the answers

    Which of the following best describes the nature of CT scans concerning their invasiveness?

    <p>Non-invasive but involves exposure to ionizing radiation</p> Signup and view all the answers

    In which scenario is D-dimer testing least likely to provide accurate results?

    <p>Post-operative state</p> Signup and view all the answers

    What procedure is generally used to collect sputum in patients unable to provide a sample voluntarily?

    <p>Bronchoscopy or suctioning</p> Signup and view all the answers

    When would a cardiopulmonary exercise stress test be most appropriate?

    <p>To evaluate unexplained dyspnea in patients</p> Signup and view all the answers

    What is a significant limitation of sputum culture in pulmonary diagnostics?

    <p>It does not ideally culture all pathogens present</p> Signup and view all the answers

    What does a mismatch in a VQ scan indicate?

    <p>Potential presence of pulmonary embolism (PE)</p> Signup and view all the answers

    How does a cardiopulmonary exercise stress test evaluate cardiac function?

    <p>Through monitoring oxygen uptake and carbon dioxide production</p> Signup and view all the answers

    What is the primary purpose of obtaining intravenous contrast in a CT scan?

    <p>To help differentiate structures or pathologies</p> Signup and view all the answers

    Study Notes

    Pulmonary DDX

    • Common differential diagnosis for the following presentations: cough, dyspnea, hypoxemia, sputum production, hemoptysis, and clubbing

    Chest X-Ray: Indications

    • Infection: exclude pneumonia, positive Mantoux test
    • Major trauma: exclude widened mediastinum, pneumothorax and hemothorax
    • Acute chest pain: exclude pneumothorax, perforated viscus, aortic dissection
    • Asthma/bronchiolitis: when diagnosis unclear and/or not responding to usual therapy
    • Acute dyspnea: exclude heart failure, pleural effusion
    • Chronic dyspnea: exclude heart failure, effusion and interstitial lung disease
    • Hemoptysis
    • Suspected mass, metastasis or lymphadenopathy

    CXR Interpretation: AP vs PA

    • Posterior-anterior (PA) view is ideal
    • PA view allows for less heart magnification and better lung visualization
    • Anterior-posterior (AP) view is often used in patients who cannot stand or in cases where the PA view is not possible

    CXR Interpretation: Systematic Approach

    • A - Assessment of Quality/Airway: Check position, inspiration, exposure, rotation, and indwelling lines/objects (ie ETT).
    • B - Bones and Soft Tissues: Check for symmetry, fractures, lesions in bones. Check soft tissue for FB, edema, subcutaneous air.
    • C - Cardiac: Evaluate heart size, check heart shape, calcifications, prosthetic valves.
    • D - Diaphragm: Check position, look below the diabetic for free air.
    • E - Effusions: Check costophrenic angles, check lateral film for small posterior effusions.
    • F - Fields, Fissures & Foreign Bodies: Check for infiltrates, masses, consolidations, pneumothoraces & vascular markings. Evaluate fissures, check for FB (lines, surgical markings).
    • G - Great Vessels & Gastric Bubble: Check aortic size/shape, check outline pulmonary vessels, verify gastric bubble position.
    • H - Hila and Mediastinum: Evaluate hila for lymphadenopathy, calcifications & masses. Check widening of mediastinum, check tracheal deviation.
    • I - Impression: Synthesis of all these findings

    CXR Interpretation: Anatomical Review

    • Right hemidiaphragm is slightly higher than left due to the presence of the liver.
    • Loss of heart border may be due to an infiltrate.

    CXR: Fluid Specifics

    • Pulmonary infiltrate: Fluid or material fill the spaces within the lungs, where air should be. Etiologies include pneumonia, pulmonary edema.
    • Pleural effusion: Fluid that accumulates between the two pleural layers, the fluid-filled space that surrounds the lungs. Etiologies include heart failure, infection, cancer.

    CXR: Invasiveness/Potential Complications

    • Non-painful, non-invasive
    • Small level of radiation, equivalent to that which naturally occurs in the environment

    PFTS: Indications

    • Evaluation for chronic cough, dyspnea
    • Assessment & monitoring of disease severity & progression
    • Monitoring for drug efficacy
    • Pre-operative assessment

    PFTS: Interpretation

    • Forced vital capacity (FVC): Maximum air inhaled & exhaled, decreased in restrictive & obstructive lung disease.
    • Forced expiratory volume in 1 sec (FEV1): Max volume of air exhaled in 1 sec, decreased in obstructive lung disease, normal or slightly decreased in restrictive lung disease.
    • FEV1/FVC ratio: Decreased in obstructive, normal in restrictive.

    PFTS: Invasiveness/Potential Complications

    • Non-invasive but requires capacity for deep breathing
    • Contraindicated in any acute event (ie MI, PE) or active TB given potential spread

    CT Scan: Indications

    • Lung Disease: ie complex chest infection (abscess, empyema), complex pleural disease
    • Vascular Occlusions (ie PE)
    • Cancer diagnosis and staging
    • Trauma

    CT Scan: Interpretation

    • Radiation through the body creates an “electron stream” which is converted to numbers (Hounsfield Units) 🡪 those numbers are converted into the black, white and shades of gray picture we view.
    • CT can take “pictures” from 1mm-10mm thick slices
    • Spiral or helical CT scan is the most common

    CT Scan: Invasiveness/Potential Complications

    • Non-invasive but has radiation dose
    • Standard is with IV contrast
    • Possible contraindications: History of reaction to contrast agents, Pregnancy, Renal dysfunction

    VQ Scan: Indications

    • = Ventilation (V) & perfusion (Q) nuclear medicine scan
    • Diagnostic for PE when CTA contraindicated but not as accurate
    • Assess for viability of good lung prior to lobe resection

    VQ Scan: Interpretation

    • Looking for a mismatch between ventilation & perfusion
    • This mismatch is suggestive of a pulmonary embolism

    VQ Scan: Invasiveness/Potential Complications

    • Non-invasive w/ lower radiation levels
    • Patient needs to inhale radioactive isotope through non-rebreather mask & also have isotope injected IV for imaging
    • Not as accurate for PE dx as CTA

    D-Dimer: Indications

    • = fibrin degradation byproduct
    • Exclude diagnose of PE/DVT
    • Part of DIC diagnosis

    D-Dimer: Interpretation

    • Highly sensitive but low specificity
    • Part of Wells Criteria for VTE work-up

    D-Dimer: Invasiveness/Potential Complications

    • Serum blood draw
    • In appropriate use of this lab can cause escalated imaging

    Cardiopulmonary Exercise Stress Testing: Indications

    • Evaluation of exercise tolerance in patients with cardiovascular disease or chronic pulmonary disease
    • Unexplained dyspnea
    • Evaluation children and adolescents with congenital heart disease
    • Pre-operative evaluation prior to heart or lung transplantation, lung resection surgery
    • Functional and prognostic evaluation of persons with

    Cardiopulmonary Exercise Stress Testing: Interpretation

    • Measures O2 uptake (VO2), carbon dioxide production (VCO2) and ventilation parameters during exercise
    • Cardiac stress test at the same time

    Cardiopulmonary Exercise Stress Testing: Invasiveness/Potential Complications

    • Requires capacity for cycle or treadmill
    • Potential complications: Fatigue, SOB, bronchospasm, cardiac arrhythmia, syncope

    Sputum Culture: Indications

    • Bronchiectasis
    • Pulmonary abscess
    • VAP
    • Unresolving ICU PNA
    • Cavitary opacities
    • PNA in immunocompromised pts

    Sputum Culture: Interpretation

    • Can aid in taper of HAP abx therapy from empiric to culture directed

    Sputum Culture: Invasiveness/Potential Complications

    • Deep cough to facilitate sputum sample
    • If patient unable to voluntary give sputum, obtained via bronchoscopy or ETT

    WBC & Differential

    • Can be helpful in identifying infection, especially with bacterial pneumonia where there may be a leukocytosis and neutrophil predominance.

    Bronchoscopy: Indications

    • Persistent cough
    • Unresolving infection
    • Bronchial obstruction
    • Potential malignancy on imaging
    • Hemoptysis
    • Concern for FB

    Bronchoscopy: Interpretation

    • Allows view of respiratory tract
    • Take samples for culture, cytology, biopsies
    • Ability to remove foreign bodies

    Bronchoscopy: Invasiveness/Potential Complications

    • Sedated but awake
    • Potential complications: bleeding, pneumothorax, infection

    Oximetry: Indications

    • Measures O2 saturation as light passes through blood in finger
    • During/after sedation
    • Acute pulmonary or cardiac complaint

    Oximetry: Interpretation/ Invasiveness/Potential Complications

    • Normal 95-100%

    Arterial Blood Gas (ABG) Interpretation

    • Step 1: Is pH abnormal?
    • Step 2: Is the respiratory (PaCO2) or metabolic (HCO3-) component abnormal? Does it correlate with the pH change?
    • Step 3: Is there compensation? This means the opposite system (respiratory or metabolic) is working to correct the imbalance.
    • Step 4: What does PaO2 tell you? This measures the partial pressure of oxygen in the arterial blood and is a measure of how well oxygen is being transferred from the lungs to the blood.

    Respiratory Acidosis

    • pH low < 7.35
    • PaCO2 high > 45 mmHg
    • HCO3- normal (22-26 mEq/L)
    • Causes: Impaired lung function, decreased respiratory rate

    Respiratory Alkalosis

    • pH high > 7.45
    • PaCO2 low < 35 mmHg
    • HCO3- normal (22-26 mEq/L)
    • Causes: Hyperventilation, anxiety , pain

    Metabolic Acidosis

    • pH low < 7.35
    • PaCO2 normal (35-45 mmHg)
    • HCO3- low < 22 mEq/L
    • Causes: Loss of bicarbonate, increased production of acid

    Metabolic Alkalosis

    • pH high > 7.45
    • PaCO2 normal (35-45 mmHg)
    • HCO3- high > 26 mEq/L
    • Causes: Increased bicarbonate, loss of acid

    ABG Interpretation Steps: Practice

    • #1: Is pH abnl?______
    • #2: Is respiratory (PaCO2) or metabolic (HCO3-) component abnl? Does it correlate w/ pH change?______
    • #3: Is there compensation?IE does the opposite system respiratory or metabolic working to correct?______
    • #4: What does PaO2 tell you?______

    Board question:

    A 36-year-old female is brought to the emergency department with altered mental status. Her medical record reflects that she has a history of depression and suicide attempts in the past. Physical exam is significant for tachypnea with an alcohol smell to her breath. ABG results: pH: 7.22, pCO2: 33, HCO3: 16, pO2: 93, Anion Gap: 24. Which of the following acid-base disorders is most likely?

    • A. Metabolic acidosis
    • B. Metabolic alkalosis
    • C. Respiratory acidosis
    • D. Respiratory alkalosis

    Upper Respiratory Tract Infection: Essentials

    • = common cold = URI
    • Children highly susceptible given lack of previous infection immunity & close contact.
    • Etiology MC rhinovirus, also RSV, coronavirus, coxsackie, adenovirus etc.
    • Peak fall to spring season
    • 1-3 days from exposure to infection

    Upper Respiratory Tract Infection: Diagnosis

    • Sxs: rhinorrhea, nasal congestion +/- fever, sore throat, occasional non-productive cough
    • PE: Swollen, erythematous nasal turbinates
    • Clinical diagnosis, no labs or diagnostics

    Upper Respiratory Tract Infection: Treatment

    • Resolves in 5-7 days
    • No antibiotics
    • 5% children will develop AOM
    • Symptomatic mgmt

    Bronchiolitis: Essentials

    • Small bronchioles w/ increased mucus & occasional bronchospasm
    • 4-6 day incubation
    • Etiology usually viral LRTI, RSV is MC.
    • MC in infants & young kids < 2 ya, peak 2-6 mos

    Bronchiolitis: Diagnosis

    • Sxs: progressive sxs, starts w/ cold like cough/rhinorrhea 🡪 raspy breathing & wheezing, fever. RSV may not have prodrome & apnea is 1st sx.
    • PE: prolonged expiratory phase, ↑ work of breathing (intercostal retractions, nasal flaring)
      • Auscultation: diffuse wheeze & crackles

    Bronchiolitis: Diagnosis

    • Labs not required for dx
    • Pulse oximetry check
    • Nasopharyngeal swab for common pathogens done to confirm infection
    • CXR if obtained shows hyperinflation, flattened diaphragms

    Bronchiolitis: Treatment

    • Admit if: High risk, marked respiratory distress, hypoxemia, apnea, inability to tolerate oral feeds.
    • Supportive therapy: Respiratory monitoring, antipyretics, hydration, upper airway suctioning, O2 prn.

    Pneumonia: Essentials

    • LRTI of airways & parenchyma w/ consolidation of alveolar spaces
    • MC Streptococcus pneumoniae.
    • Also RSV, parainfluenza, influenza, adenovirus
    • Mycoplasma pneumoniae > 5 ya

    Pneumonia: Diagnosis

    • Sxs: cough, wheezing, hemoptysis, chest pain, abdominal pain, failure to thrive, F/C
    • PE: Fever, tachypnea, retractions, splinting. Auscultation: crackles, rhonchi over consolidation.
    • CBC: ↑ WBC, utilize diff to help delineate etiology

    Pneumonia: Diagnosis

    • Clinical dx in outpatient children
    • Hospitalized pts: CXR, blood cultures

    Pneumonia: Treatment

    • Admit w/ hypoxemia, inability to maintain hydration or moderate respiratory distress. Pts < 6 mos old w/ bacterial PNA or care concerns.
    • When bacterial, tx w/ abx therapy

    Foreign Body Aspiration: Essentials

    • Usually < 3 ya
    • Most commonly lodge in the right main bronchus
    • Most often small food & toys

    Foreign Body Aspiration: Diagnosis/Treatment

    • Sxs: cough, stridor, hemoptysis, may have history of choking, witnessed event
    • PE: localized wheezing or unilateral absence of breath sounds
    • Imaging: Radiopaque objects visualized, note focal air trapping
    • Bronchoscopy for FB removal

    Dermatology Review

    • A 25-year-old male reports he went hiking a week ago. At the end of the day, his friend noticed a tick on him and removed it. The patient now reports fever, chills and body aches and has a skin lesion where the tick bit him. The lesion has a red border with central clearing. Which of the following is the most appropriate intervention?

    • C. Doxycycline

    • A. Acetaminophen

    • B. Ceftriaxone

    • D. Erythromycin

    • E. Rifampin

    Hematology Review

    • Which of the following best describes the laboratory evaluation of a patient diagnosed with acute myeloid leukemia?

    • D. Pancytopenia with circulating blasts and presence of Auer rods

    • A. Elevated WBC > 10,000, Philadelphia chromosome

    • B. Isolated lymphocytosis, lymphocytes appear small & immature

    • C. Pancytopenia & hairy cells

    Cardiology Review

    • A 20-year-old woman complains of easy fatigability. Physical examination reveals a systolic ejection murmur best heard over the pulmonic region and a fixed split second heart sound. Which of the following is the most likely diagnosis?

    • C. Atrial septal defect

    • A. Aortic stenosis

    • B. Ventricular septal defect

    • D. Mitral regurgitation

    • E. Tricuspid regurgitation

    CXR Interpretation: Anatomical Review

    • Check position of the endotracheal tube
    • Look below the diaphragm for free air
    • Check costophrenic angles for blunting which may indicate a small pleural effusion
    • Check the lateral film for small posterior effusions
    • Evaluate for infiltrates
    • Identify any masses, consolidations, pneumothoraces, and vascular markings
    • Assess the fissures
    • Check for foreign bodies like lines or surgical markings
    • Evaluate the aortic size and shape
    • Check the outline of the pulmonary vessels
    • Verify the position of the gastric bubble
    • Evaluate the hila for lymphadenopathy, calcifications, and masses
    • Check for widening of the mediastinum which can be associated with a variety of conditions
    • Check for tracheal deviation: this can indicate a mass effect or tension pneumothorax
    • Summarize all findings in the impression for comprehensive understanding

    CXR: Fluid Specifics

    • Pulmonary infiltrate: fluid or material filling the lung spaces
    • Pleural effusion: fluid accumulating between the two pleural layers, surrounding the lungs

    CXR: Invasivness/Potential Complications

    • Non-invasive and painless
    • Can be performed bedside or in the X-ray unit
    • Patients should be still in a gown, take a deep breath, and hold it with arms above their heads
    • Involves a small level of radiation, equivalent to environmental levels

    PFTS: Indications

    • Evaluation of chronic cough and dyspnea
    • Assessment and monitoring of disease severity and progression
    • Monitoring drug efficacy
    • Pre-operative assessment

    PFTS: Interpretation

    • Forced vital capacity (FVC): maximum air inhaled and exhaled
      • Decreased FVC suggests restrictive or obstructive lung disease
    • Forced expiratory volume in 1 second (FEV1): maximum volume of air exhaled in one second
      • Decreased FEV1 strongly suggests obstructive lung disease
      • Normal or slightly decreased FEV1 may suggest restrictive disease
    • FEV1/FVC ratio: decreased ratio suggests obstructive disease, normal ratio suggests restrictive disease

    PFTS: Invasivness/Potential Complications

    • Non-invasive but requires the ability to take deep breaths
    • Contraindicated in acute events like myocardial infarction, pulmonary embolism, or active tuberculosis due to potential spread

    CT Scan: Indications

    • Lung disease like complex chest infections (abscess, empyema), or complex pleural disease
    • Vascular occlusions, like pulmonary embolism
    • Cancer diagnosis and staging
    • Trauma

    CT Scan: Interpretation

    • Radiation through the body creates an electron stream that is converted to numbers (Hounsfield Units), which are then displayed as a black, white, and gray image, representing density data
    • CT scans can take pictures from 1 mm to 10 mm thick slices
      • 1 mm: small structures like the inner ear
      • 10 mm: large structures in the abdomen and chest
    • Spiral or helical CT scan is the most common type
    • CT windows: display settings (ie. lung window, bone window) that manipulate the appearance of the image
    • The mouse allows you to center the window on the desired tissue and adjust the ability to distinguish objects with varying contrast

    CT Scan: Invasivness/Potential Complications

    • Non-invasive but involves a radiation dose
    • Standard CT scans involve IV contrast
      • Contrast: iodine that causes varying degrees of x-ray absorption, improving visualization
      • Possible contraindications to contrast:
        • History of reaction to contrast agents
        • Pregnancy
        • Renal dysfunction

    VQ Scan: Indications

    • Ventilation (V) and perfusion (Q) nuclear medicine scan
    • Used to diagnose pulmonary embolism when CTA is contraindicated
    • Assess the viability of good lung tissue before lobe resection

    VQ Scan: Interpretation

    • Looks for a mismatch between ventilation and perfusion

    VQ Scan: Invasivness/Potential Complications

    • Non-invasive with low radiation levels
    • Patients inhale a radioactive isotope through a non-rebreather mask and also have an isotope injected intravenously for imaging
    • Not as accurate for pulmonary embolism diagnosis as CTA

    D-Dimer: Indications

    • Fibrin degradation byproduct
    • Used to exclude the diagnosis of pulmonary embolism or deep vein thrombosis
    • Part of disseminated intravascular coagulation (DIC) diagnosis

    D-Dimer: Interpretation

    • Highly sensitive but low specificity, meaning it has a high number of false positives
    • Part of the Wells Criteria for VTE work-up

    D-Dimer: Invasivness/Potential Complications

    • Serum blood draw
    • Inappropriate use of this lab test can lead to escalated imaging and unnecessary investigations
    • Avoid ordering D-dimer tests when the results are likely to be positive (ie. post-operative, trauma, infectious)

    Cardiopulmonary Exercise Stress Testing: Indications

    • Evaluation of exercise tolerance in patients with cardiovascular disease or chronic pulmonary disease
    • Unexplained dyspnea
    • Evaluation of children and adolescents with congenital heart disease
    • Pre-operative evaluation prior to heart or lung transplantation, lung resection surgery
    • Functional and prognostic evaluation of persons with

    Cardiopulmonary Exercise Stress Testing: Interpretation

    • Measures oxygen uptake (VO2), carbon dioxide production (VCO2), and ventilation parameters during exercise
    • Cardiac stress testing can be performed simultaneously

    Cardiopulmonary Exercise Stress Testing: Invasivness/Potential Complications

    • Requires the ability to cycle or use a treadmill
    • Potential complications: fatigue, shortness of breath, bronchospasm, cardiac arrhythmia, syncope

    Sputum Culture: Indications

    • Bronchiectasis
    • Pulmonary abscess
    • Ventilator-associated pneumonia (VAP)
    • Unresolving intensive care unit (ICU) pneumonia
    • Cavitary opacities
    • Pneumonia in immuncompromised patients

    Sputum Culture: Interpretation

    • Can assist in tapering antibiotic therapy from empiric to culture-directed treatment
    • Not ideal for all pathogens

    Sputum Culture: Invasivness/Potential Complications

    • Requires a deep cough to facilitate sputum sample
    • If a patient is unable to produce sputum voluntarily, it can be obtained via bronchoscopy or endotracheal tube

    WBC and Differential: Indications

    • Indicate the presence of infection
    • Indicate the presence of inflammation
    • Help differentiate between bacterial and viral etiologies

    Bronchiolitis: Treatment

    • Admission criteria:
      • High-risk patients: premature, lung or heart disease, immunodeficiency
      • Marked respiratory distress
      • Hypoxemia
      • Apnea
      • Inability to tolerate oral fluids
    • Supportive therapy
      • Respiratory monitoring
      • Antipyretics
      • Hydration
      • Upper airway suctioning
      • Oxygen as needed

    Pneumonia: Essentials

    • Lower respiratory tract infection of the airways and parenchyma with alveolar consolidation
    • Most common cause: Streptococcus pneumoniae
    • Other causes: respiratory syncytial virus (RSV), parainfluenza, influenza, adenovirus, Mycoplasma pneumoniae (greater than 5 years of age)

    Pneumonia: Diagnosis

    • Symptoms: cough, wheezing, hemoptysis, chest pain, abdominal pain, failure to thrive, fever and chills
      • Neonates: fever and hypoxemia
      • Infants: apnea
    • Physical examination: fever, tachypnea, retractions, splinting, auscultation findings of crackles or rhonchi over consolidation
    • Hospitalized patients: chest x-ray, blood cultures

    Pneumonia: Treatment

    • Admission criteria: hypoxemia, inability to maintain hydration, or moderate respiratory distress
      • Patients less than 6 months old with bacterial pneumonia or concerns about care
    • Bacterial pneumonia: treat with antibiotic therapy

    Foreign Body Aspiration: Essentials

    • Usually occurs in children younger than 3 years old
    • Foreign bodies most commonly lodge in the right main bronchus
    • Most frequent foreign bodies: small food items and toys

    Foreign Body Aspiration: Diagnosis/Treatment

    • Symptoms: cough, stridor, hemoptysis
      • May have a history of choking or a witnessed event
    • Physical examination: localized wheezing or unilateral absence of breath sounds
      • Imaging: radiopaque objects visible, note focal air trapping
    • Bronchoscopy: used for foreign body removal

    Dermatology Review

    • A red-bordered rash with central clearing is consistent with Lyme disease. Lyme disease is caused by a tick-borne bacteria.
    • The most appropriate intervention for Lyme disease is doxycycline.
    • Other options include:
      • Acetaminophen: can manage fever
      • Ceftriaxone: effective for Lyme disease but not the first-line treatment
      • Erythromycin: not the first-line treatment, but can be used
      • Rifampin: not the appropriate treatment for Lyme disease

    Hematology Review

    • Acute myeloid leukemia is characterized by pancytopenia (low red blood cells, white blood cells, and platelets), circulating blasts, and the presence of Auer rods.

    Cardiology Review

    • A fixed split second heart sound and a systolic ejection murmur best heard over the pulmonic region are consistent with an atrial septal defect.

    Questions?

    • Radiopaedia is a website with comprehensive medical imaging resources and information.

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    Description

    This quiz focuses on the differential diagnoses related to pulmonary presentations, including cough and dyspnea. It also covers indications for chest X-rays and the systematic approach for interpreting AP and PA views. Test your knowledge on critical respiratory conditions and imaging techniques.

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