Sanford Guide: Pulmonary Hypertension Medications Quiz
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Questions and Answers

Which type of medication is commonly used for asthma emergencies to rapidly open airways?

  • Leukotriene blockers
  • Endothelin receptor antagonists
  • Epinephrine (correct)
  • Phosphodiesterase 5 inhibitors (PDE5I)

What is the main mechanism of action of inhaled beta-2 agonists like albuterol for asthma treatment?

  • Increased leukotriene production
  • Inhibition of prostaglandin synthesis
  • Increase in cAMP in bronchial smooth muscle (correct)
  • Smooth muscle constriction

What is a common adverse effect of inhaled beta-2 agonists?

  • Gastrointestinal bleeding
  • Hypertension
  • Arrhythmia (correct)
  • Bronchoconstriction

Why are long-acting beta-2 agonists (LABAs) not recommended for acute shortness of breath?

<p>They mask the severity of symptoms (B)</p> Signup and view all the answers

Which receptor does epinephrine stimulate that leads to cardiovascular stimulation in asthma emergencies?

<p>Beta-1 adrenergic receptors (C)</p> Signup and view all the answers

What is a possible reason why long-acting beta-2 agonists (LABAs) are not suitable for monotherapy in asthma treatment?

<p>They may increase mortality rates in some patients (D)</p> Signup and view all the answers

Which type of medication is known for causing hypotension and priapism?

<p>Phosphodiesterase 5 inhibitors (PDE5I) (A)</p> Signup and view all the answers

How are Vasoreactive and Non-vasoreactive Pulmonary Hypertension treated differently?

<p>Vasoreactive with ERA and Non-vasoreactive with PDE-Inhibitor (C)</p> Signup and view all the answers

Which type of medication has very serious side effects, yet is slightly different in selectivity?

<p>Endothelin receptor antagonists (ERAs) (D)</p> Signup and view all the answers

What is the minimum duration of treatment with anticoagulants for Pulmonary Embolism (PE)?

<p>3 months (C)</p> Signup and view all the answers

Which condition is likely underdiagnosed but should be in the differential diagnosis for shortness of breath (SOB)?

<p>Pulmonary Embolism (PE) (D)</p> Signup and view all the answers

Which class of medications generally have fewer side effects compared to others mentioned in the text?

<p>Phosphodiesterase 5 inhibitors (PDE5I) (B)</p> Signup and view all the answers

What is the initial treatment tried in vasoreactive patients with pulmonary hypertension?

<p>High dose calcium channel blockers (D)</p> Signup and view all the answers

Which medication combination is commonly used in non-vasoreactive patients with pulmonary hypertension?

<p>Ambrisentan (ERA) + sildenafil (PDE5I) (D)</p> Signup and view all the answers

What are the adverse effects associated with Endothelin receptor antagonists (ERAs)?

<p>Hepatotoxicity and peripheral edema (D)</p> Signup and view all the answers

Why are ERAs contraindicated during pregnancy?

<p>They are powerful teratogens (B)</p> Signup and view all the answers

Which receptor types play a role in vasodilation and vasoconstriction in the context of pulmonary hypertension medications?

<p>ETA receptors constrict, ETB receptors dilate (D)</p> Signup and view all the answers

How do Phosphodiesterase 5 inhibitors (PDE5Is) work in pulmonary hypertension?

<p>Increase cAMP levels (B)</p> Signup and view all the answers

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