Questions and Answers
What is the class of polyethylene glycol (Miralax)?
What is the route of administration for polyethylene glycol?
Oral
What is the dosing for colonoscopy preparation?
238 g in 2 L of sports drink orally on the day before the procedure
What is the primary use of polyethylene glycol?
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What is the oral dosing/administration for polyethylene glycol?
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What are the contraindications for polyethylene glycol?
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What precautions should be taken when using polyethylene glycol?
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What are some adverse effects of polyethylene glycol?
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What is the pregnancy category for polyethylene glycol?
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What should be monitored when using polyethylene glycol?
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What is the mechanism of action (MOA) of polyethylene glycol?
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What important advice should be given to patients taking polyethylene glycol?
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Study Notes
Polyethylene Glycol (Miralax) Overview
- Classed as a gastrointestinal agent, used primarily to treat constipation.
- Administered orally, making it convenient for patient use.
Dosing Information
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Colonoscopy Preparation:
- 238 g mixed in 2 L of sports drink, taken the day before the procedure.
- For split-dose regimen, consume 1 L the day before and 1 L on the day of the procedure.
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General Constipation:
- 17 g (approximately 1 heaping tablespoon) orally per day, mixed in 4 to 8 ounces of a beverage; maximum duration of 2 weeks.
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Chronic Constipation:
- Same dosage as general constipation but can be taken for up to 6 months.
Administration Guidelines
- Mix the powder in 8 oz of water, juice, soda, coffee, or tea prior to taking the medication.
Contraindications
- Not suitable for individuals with hypersensitivity to polyethylene glycol or those with known or suspected bowel obstructions.
Precautions to Consider
- Assess for symptoms of bowel obstruction (nausea, vomiting, abdominal pain, distension).
- Use is contraindicated if bowel obstruction or perforation is present.
Adverse Effects
- Common gastrointestinal side effects include diarrhea, flatulence, nausea, stomach cramps, and a swollen abdomen.
Pregnancy Category
- Classified as category C, indicating risk is not ruled out without appropriate studies.
Monitoring Parameters
- Monitor for decreased abdominal discomfort and pain.
- Expect bowel movements within 2 to 4 days of initial dosing.
- Check for electrolyte imbalances with prolonged, frequent, or excessive use.
Mechanism of Action (MOA)
- Functions as an osmotic agent, helping to retain water in the stool, resulting in softer stools and more frequent bowel movements.
- Does not affect the active absorption or secretion of glucose or electrolytes.
Medication Counseling Points
- Patients should be aware of potential side effects and that symptomatic relief might not occur for 2 to 4 days.
- Inform about various brand names and their specific properties and instructions.
- Advise against use for more than 2 weeks unless directed by a healthcare professional.
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Test your knowledge on Polyethylene Glycol (Miralax) with these flashcards. Covering key concepts such as its classification as a gastrointestinal agent, administration routes, and dosing guidelines, this quiz is perfect for students and healthcare professionals alike.