Plectin Mutations and Associated Diseases
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Questions and Answers

What is the function of the intermediate filaments in the nuclear lamina?

  • Maintaining the structure of the nuclear envelope
  • Providing attachment sites for microtubules
  • Providing attachment sites for chromatin (correct)
  • Regulating the dynamics of actin filaments

    • What is the consequence of defects in a nuclear lamin?

  • Increased cellular migration and invasion
  • Impaired cell division and increased cell death (correct)
  • Accelerated cell growth and proliferation
  • Enhanced tissue repair and cellular differentiation

    • What is the composition of the nuclear lamina?

  • A network of actin filaments
  • A complex of cytoskeletal protein networks
  • A meshwork of microtubules
  • A square lattice of intermediate filaments composed of lamins (correct)

    • What is the effect of plectin mutations on skin and muscle?

    <p>It causes features of epidermolysis bullosa simplex and muscular dystrophy</p> Signup and view all the answers

    What is the characteristic of intermediate filaments in cells treated with concentrated salt solutions?

    <p>They can stay intact and resist disassembly</p> Signup and view all the answers

    What is the location of intermediate filaments in cells?

    <p>In both the cytoplasm and the nucleus</p> Signup and view all the answers

    What type of intermediate filament is found in nerve cells?

    <p>Neurofilaments</p> Signup and view all the answers

    What is the main function of microtubules in a cell?

    <p>To act as a track for the movement of vesicles and organelles</p> Signup and view all the answers

    What type of intermediate filament is associated with the nuclear envelope?

    <p>Lamins</p> Signup and view all the answers

    What is the characteristic of microtubules that allows them to rapidly change their location in the cell?

    <p>Their ability to polymerize and depolymerize</p> Signup and view all the answers

    What is the function of plectin in intermediate filament networks?

    <p>To cross-link intermediate filaments together</p> Signup and view all the answers

    What is the term for the process of premature aging caused by mutations in a nuclear protein?

    <p>Progeria</p> Signup and view all the answers

    What is the primary function of intermediate filaments in cells?

    <p>To provide mechanical stress resistance</p> Signup and view all the answers

    What would occur if a sheet of epithelial cells were stretched by external forces in the absence of intermediate filaments?

    <p>The cells would experience a major deformation and possibly rupture</p> Signup and view all the answers

    What protein aids in the bundling of intermediate filaments and links them to other cytoskeletal protein networks?

    <p>Plectin</p> Signup and view all the answers

    Which of the following is NOT a type of cytoskeletal protein network?

    <p>Golgi apparatus</p> Signup and view all the answers

    What is the name of the disease caused by a mutant form of keratin that makes skin more prone to blistering?

    <p>Epidermolysis bullosa simplex</p> Signup and view all the answers

    What is the role of intermediate filaments in maintaining cell shape and structure?

    <p>They resist mechanical stress and maintain cell shape</p> Signup and view all the answers

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