Plant Antitumor Agents in Cancer Treatment

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Which of the following is NOT a main form of treatment for cancer in humans?

Drugs (chemotherapy)

Immunotherapy (correct)

Radiation

Surgery

Which plant-based compound is derived from Taxus brevifolia and is used in the treatment of ovarian and advanced breast cancer?

Podophyllotoxin

Vinca alkaloids

Paclitaxel (Taxol) (correct)

Camptothecin

What is the mechanism of action of Paclitaxel (Taxol)?

Enhancement of tubulin polymerization and promotion of microtubule assembly (correct)

Inhibition of DNA synthesis

Suppression of cell division

Inhibition of protein synthesis

What is the toxicity associated with the use of Paclitaxel (Taxol)?

Peripheral neuropathy Signup and view all the answers

Which plant contains the compound Camptothecin, used for its antitumor properties?

Camptotheca acuminata Signup and view all the answers

Which plant contains betulinic acid and is known for inducing apoptosis in cancer cells?

Betula alba Signup and view all the answers

Which drug, derived from podophyllum peltatum, is used for lung, testicular cancer, and lymphomas?

Etoposide (Vepeside) Signup and view all the answers

Which plant contains vinca alkaloids and is used in the treatment of systemic Hodgkin’s disease and other lymphomas?

Catharanthus roseus Signup and view all the answers

Which drug, based on natural products, has benefited cardiology and is derived from salicin?

Aspirin Signup and view all the answers

Which plant is one of the first to show some promise in fighting HIV/AIDS?

Castanospermum australe (Moreton Bay Chestnut or Blackbean) Signup and view all the answers

Which plant-based compound is derived from Betula alba and is known for killing melanoma cells without affecting healthy cells?

Betulinic acid Signup and view all the answers

Which drug, derived from Catharanthus roseus, is used in the treatment of acute leukemia in children?

Vincristine Signup and view all the answers

What is the significant dose-limiting effect associated with drugs derived from topoisomerase Ⅰ interference?

Neutropenia Signup and view all the answers

Which plant is a source of steroidal drugs like progesterone and has been historically used to help stop bleeding of injured soldiers?

Sphagnum moss Signup and view all the answers

Which drug, derived from Podophyllum peltatum, is contraindicated in pregnancy and used for brain tumors?

Teniposide Signup and view all the answers

Which of the following is NOT a potential benefit of chemotherapy in cancer treatment?

Complete eradication of the tumor Signup and view all the answers

What is the primary source of taxol for the treatment of cancer?

Camptotheca acuminata Signup and view all the answers

What is the primary mechanism of action of taxol in cancer treatment?

Inhibition of tubulin polymerization Signup and view all the answers

Which of the following is a constituent of Taxus brevifolia, the Pacific yew?

Vinca alkaloids Signup and view all the answers

What is the primary clinical use of camptothecin?

Cardiovascular diseases Signup and view all the answers