Plant Antitumor Agents in Cancer Treatment
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Questions and Answers

Which of the following is NOT a main form of treatment for cancer in humans?

  • Drugs (chemotherapy)
  • Immunotherapy (correct)
  • Radiation
  • Surgery

Which plant-based compound is derived from Taxus brevifolia and is used in the treatment of ovarian and advanced breast cancer?

  • Podophyllotoxin
  • Vinca alkaloids
  • Paclitaxel (Taxol) (correct)
  • Camptothecin

What is the mechanism of action of Paclitaxel (Taxol)?

  • Enhancement of tubulin polymerization and promotion of microtubule assembly (correct)
  • Inhibition of DNA synthesis
  • Suppression of cell division
  • Inhibition of protein synthesis

What is the toxicity associated with the use of Paclitaxel (Taxol)?

<p>Peripheral neuropathy (C)</p> Signup and view all the answers

Which plant contains the compound Camptothecin, used for its antitumor properties?

<p>Camptotheca acuminata (B)</p> Signup and view all the answers

Which plant contains betulinic acid and is known for inducing apoptosis in cancer cells?

<p>Betula alba (D)</p> Signup and view all the answers

Which drug, derived from podophyllum peltatum, is used for lung, testicular cancer, and lymphomas?

<p>Etoposide (Vepeside) (C)</p> Signup and view all the answers

Which plant contains vinca alkaloids and is used in the treatment of systemic Hodgkin’s disease and other lymphomas?

<p>Catharanthus roseus (C)</p> Signup and view all the answers

Which drug, based on natural products, has benefited cardiology and is derived from salicin?

<p>Aspirin (D)</p> Signup and view all the answers

Which plant is one of the first to show some promise in fighting HIV/AIDS?

<p>Castanospermum australe (Moreton Bay Chestnut or Blackbean) (C)</p> Signup and view all the answers

Which plant-based compound is derived from Betula alba and is known for killing melanoma cells without affecting healthy cells?

<p>Betulinic acid (D)</p> Signup and view all the answers

Which drug, derived from Catharanthus roseus, is used in the treatment of acute leukemia in children?

<p>Vincristine (B)</p> Signup and view all the answers

What is the significant dose-limiting effect associated with drugs derived from topoisomerase Ⅰ interference?

<p>Neutropenia (A)</p> Signup and view all the answers

Which plant is a source of steroidal drugs like progesterone and has been historically used to help stop bleeding of injured soldiers?

<p>Sphagnum moss (B)</p> Signup and view all the answers

Which drug, derived from Podophyllum peltatum, is contraindicated in pregnancy and used for brain tumors?

<p>Teniposide (B)</p> Signup and view all the answers

Which of the following is NOT a potential benefit of chemotherapy in cancer treatment?

<p>Complete eradication of the tumor (A)</p> Signup and view all the answers

What is the primary source of taxol for the treatment of cancer?

<p>Camptotheca acuminata (C)</p> Signup and view all the answers

What is the primary mechanism of action of taxol in cancer treatment?

<p>Inhibition of tubulin polymerization (C)</p> Signup and view all the answers

Which of the following is a constituent of Taxus brevifolia, the Pacific yew?

<p>Vinca alkaloids (D)</p> Signup and view all the answers

What is the primary clinical use of camptothecin?

<p>Cardiovascular diseases (C)</p> Signup and view all the answers

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