Questions and Answers
What is the size of the diameter of picornaviruses?
~30nm
Which viral proteins form the capsid shell in a mature picornavirus?
VP1-3
What is the function of the internal ribosome entry site (IRES) in picornaviruses?
Allow initiation of translation without having a 5’ cap
What is covalently bound to the 5’ end of the RNA in picornaviruses?
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What is the mechanism by which most cellular RNAs initiate translation near their 5' end?
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What is the consequence of Picornavirus infection on host cell cap-dependent translation?
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What role do host cell proteins play in Picornavirus translation process?
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What is the fate of the precursor polyprotein made during Picornavirus protein synthesis?
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What initiates the replication of Picornavirus RNAs in host cells?
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What is the major conformational change in poliovirus that facilitates its entry into the cytoplasm?
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What is the function of VP0 during poliovirus assembly?
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What are the consequences of Picornavirus infection on host cell macromolecular functions?
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