Physiologic Factors of Drug Distribution

Drug distribution involves the transfer of drug from one location to another within the body. (True/False)

The distribution of drugs in the body depends on factors such as blood flow, capillary permeability, and protein binding. (True/False)

Organs with higher blood flow, such as kidneys, liver, and brain, will theoretically have a decrease in drug distribution. (True/False)

Solubility is a factor that influences drug distribution in the body. (True/False)

Adipose tissues receive higher blood flow compared to organs like the liver and brain. (True/False)

Factors influencing drug distribution include blood flow, capillary permeability, and protein binding. (True/False)

In septic shock, there is a decrease in blood flow, leading to an increase in drug distribution.

Organs such as the liver, bone marrow, and spleen have special type of capillaries called continuous capillaries.

The blood brain barrier (BBB) has capillaries with large intracellular clefts and fenestration pores.

The diffusion of drugs out of the blood into tissue spaces is dependent on transporters and low lipophilicity of the drug.

In patients with capillary leak syndrome, the distribution of drugs will decrease due to reduced capillary permeability.

Proteins like albumin bind with drugs inside the blood, leading to an increase in the amount of free drug available for distribution.

Patients with septic shock require lower doses of antibiotics due to high leakage into the tissues.

The ability of drugs to move out of the blood vessels into tissue spaces is reduced in organs with continuous capillaries.

Organs like the liver and spleen have capillaries with high permeability, allowing for easy distribution of drugs into tissue spaces.

Patients with capillary leak syndrome may not have drug distributed to the tissues that need it.