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Questions and Answers
What is the endocon involved in glucuronidation?
What is the endocon involved in glucuronidation?
Which type of drugs are excreted as O-glucuronides at high doses?
Which type of drugs are excreted as O-glucuronides at high doses?
Which of the following is NOT a Phase II conjugation reaction?
Which of the following is NOT a Phase II conjugation reaction?
What is the major substrate for 3-O-glucuronide formation?
What is the major substrate for 3-O-glucuronide formation?
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Which Phase II reaction involves inversion of configuration?
Which Phase II reaction involves inversion of configuration?
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Study Notes
Glucuronidation
- The endoplasmic reticulum (endocon) is involved in glucuronidation.
Drug Excretion
- Certain drugs are excreted as O-glucuronides at high doses.
Phase II Conjugation Reactions
- N-Acetylation is NOT a Phase II conjugation reaction.
3-O-Glucuronide Formation
- The major substrate for 3-O-glucuronide formation is Bilirubin.
Phase II Reactions
- Glucuronidation involves inversion of configuration, making it a unique Phase II reaction.
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Description
Test your knowledge of drug metabolism with this quiz on "Chemistry of Drug Metabolism II". Explore Phase II or Conjugation Reactions, the role of transferase enzymes, and the involvement of cofactors in catalyzing these reactions.
