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Questions and Answers
What is the endocon involved in glucuronidation?
What is the endocon involved in glucuronidation?
- Highly polar with size comparable to the substrate (correct)
- Highly polar with small size
- Non-polar with small size
- Non-polar with large size
Which type of drugs are excreted as O-glucuronides at high doses?
Which type of drugs are excreted as O-glucuronides at high doses?
- Alcohol drugs
- Sulfate drugs
- Amino acid drugs
- Phenolic drugs (correct)
Which of the following is NOT a Phase II conjugation reaction?
Which of the following is NOT a Phase II conjugation reaction?
- Sulfate conjugation
- Methylation
- Hydroxylation (correct)
- Glucuronidation
What is the major substrate for 3-O-glucuronide formation?
What is the major substrate for 3-O-glucuronide formation?
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Which Phase II reaction involves inversion of configuration?
Which Phase II reaction involves inversion of configuration?
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Study Notes
Glucuronidation
- The endoplasmic reticulum (endocon) is involved in glucuronidation.
Drug Excretion
- Certain drugs are excreted as O-glucuronides at high doses.
Phase II Conjugation Reactions
- N-Acetylation is NOT a Phase II conjugation reaction.
3-O-Glucuronide Formation
- The major substrate for 3-O-glucuronide formation is Bilirubin.
Phase II Reactions
- Glucuronidation involves inversion of configuration, making it a unique Phase II reaction.
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