Podcast
Questions and Answers
Which environmental factor is NOT associated with the risk of developing cleft palate?
Which environmental factor is NOT associated with the risk of developing cleft palate?
- Lack of vitamins during pregnancy
- Rubella infection
- Alcohol consumption during pregnancy
- Genetic predisposition (correct)
What is one of the structures derived from the first arch's Meckel’s cartilage?
What is one of the structures derived from the first arch's Meckel’s cartilage?
- Stapes
- Styloid process
- Hyoid bone
- Malleus (correct)
What type of ossification is responsible for the development of the mandible from the first arch?
What type of ossification is responsible for the development of the mandible from the first arch?
- Intramembranous ossification (correct)
- Chondral ossification
- Endochondral ossification
- Cartilage ossification
What cartilage does the second arch develop from, contributing to structures like the stapes?
What cartilage does the second arch develop from, contributing to structures like the stapes?
Which bone is NOT formed through the direct ossification of the first arch mesenchyme?
Which bone is NOT formed through the direct ossification of the first arch mesenchyme?
What type of tissue gives rise to the optic placodes?
What type of tissue gives rise to the optic placodes?
What structures contribute to the formation of the primary palate?
What structures contribute to the formation of the primary palate?
Which structure is NOT a component of the secondary palate?
Which structure is NOT a component of the secondary palate?
What is the most likely consequence of a complete cleft palate?
What is the most likely consequence of a complete cleft palate?
What is the primary function of the palate?
What is the primary function of the palate?
Which of the following statements is TRUE regarding the formation of the palate?
Which of the following statements is TRUE regarding the formation of the palate?
Which of the following IS NOT a possible combination of cleft palate and cleft lip?
Which of the following IS NOT a possible combination of cleft palate and cleft lip?
Which of the following statements regarding the formation of the soft palate is TRUE?
Which of the following statements regarding the formation of the soft palate is TRUE?
What is a potential consequence of ectopic thyroid tissue at the base of the tongue?
What is a potential consequence of ectopic thyroid tissue at the base of the tongue?
Which cranial nerve innervates the muscles derived from the 2nd pharyngeal arch?
Which cranial nerve innervates the muscles derived from the 2nd pharyngeal arch?
What is the primary role of the 3rd pharyngeal arch in development?
What is the primary role of the 3rd pharyngeal arch in development?
Which muscle is associated with the 4th pharyngeal arch?
Which muscle is associated with the 4th pharyngeal arch?
What type of muscle originates from the pharyngeal arches?
What type of muscle originates from the pharyngeal arches?
Which pharyngeal arch does not give rise to any bones but instead contributes only cartilage?
Which pharyngeal arch does not give rise to any bones but instead contributes only cartilage?
What is the primary function of the muscles attached to the hyoid bone?
What is the primary function of the muscles attached to the hyoid bone?
Which of the following muscles is specifically innervated by the 9th cranial nerve?
Which of the following muscles is specifically innervated by the 9th cranial nerve?
How many well-defined pharyngeal pouches are there in development?
How many well-defined pharyngeal pouches are there in development?
What arises from the first pharyngeal groove?
What arises from the first pharyngeal groove?
At what week do levels of thyroxine and fetal thyroid-stimulating hormone start to increase significantly?
At what week do levels of thyroxine and fetal thyroid-stimulating hormone start to increase significantly?
What is the consequence of the atrophy of the thyroglossal duct?
What is the consequence of the atrophy of the thyroglossal duct?
Which syndrome is characterized by hypoplasia of the mandible and facial bones?
Which syndrome is characterized by hypoplasia of the mandible and facial bones?
What connects the thyroid diverticulum to the floor of the pharynx during development?
What connects the thyroid diverticulum to the floor of the pharynx during development?
Which of the following is a common component of First Arch Syndrome?
Which of the following is a common component of First Arch Syndrome?
What structural complications can arise from remnants of the thyroglossal duct?
What structural complications can arise from remnants of the thyroglossal duct?
Which of the following issues is commonly associated with First Arch Syndrome?
Which of the following issues is commonly associated with First Arch Syndrome?
What does the first pharyngeal pouch develop into?
What does the first pharyngeal pouch develop into?
Which statement about lymphoid tissue origin is correct?
Which statement about lymphoid tissue origin is correct?
What do the dorsal and ventral divisions of the 4th pharyngeal pouch develop into?
What do the dorsal and ventral divisions of the 4th pharyngeal pouch develop into?
What is the fate of the 3rd pharyngeal pouch?
What is the fate of the 3rd pharyngeal pouch?
Which of the following is NOT derived from the 4th pharyngeal pouch?
Which of the following is NOT derived from the 4th pharyngeal pouch?
Which structure is directly associated with the 2nd pharyngeal pouch?
Which structure is directly associated with the 2nd pharyngeal pouch?
Which layer contributes to the formation of the thymus?
Which layer contributes to the formation of the thymus?
How does the Eustachian tube aid during changes in atmospheric pressure?
How does the Eustachian tube aid during changes in atmospheric pressure?
Flashcards
Primary Palate
Primary Palate
The initial part of the palate formed from the fusion of the two medial nasal processes.
Secondary Palate
Secondary Palate
The larger part of the palate, formed from the fusion of the two palatine processes.
Fusion
Fusion
The process of two tissues coming together and uniting to form a single structure.
Palate
Palate
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Cleft Palate
Cleft Palate
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Cleft Lip
Cleft Lip
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Cleft Lip and Palate
Cleft Lip and Palate
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Maxillary Processes
Maxillary Processes
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Endochondral Ossification
Endochondral Ossification
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Direct Ossification (Membranous Ossification)
Direct Ossification (Membranous Ossification)
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Meckel's Cartilage
Meckel's Cartilage
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Reichert's Cartilage
Reichert's Cartilage
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What is the hyoid bone?
What is the hyoid bone?
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How is the hyoid bone formed?
How is the hyoid bone formed?
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What are pharyngeal arches?
What are pharyngeal arches?
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What type of muscle is derived from the pharyngeal arches?
What type of muscle is derived from the pharyngeal arches?
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What muscles are derived from the first pharyngeal arch?
What muscles are derived from the first pharyngeal arch?
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What muscles are derived from the second pharyngeal arch?
What muscles are derived from the second pharyngeal arch?
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What muscle is derived from the third pharyngeal arch?
What muscle is derived from the third pharyngeal arch?
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What muscles are derived from the fourth pharyngeal arch?
What muscles are derived from the fourth pharyngeal arch?
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What is the tubotympanic recess?
What is the tubotympanic recess?
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What is Waldeyer's Ring?
What is Waldeyer's Ring?
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How does the Eustachian tube form?
How does the Eustachian tube form?
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What is the pharyngotympanic tube connected to?
What is the pharyngotympanic tube connected to?
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How do the palatine tonsils form?
How do the palatine tonsils form?
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What does the 3rd pharyngeal pouch form?
What does the 3rd pharyngeal pouch form?
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What does the 4th pharyngeal pouch form?
What does the 4th pharyngeal pouch form?
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What is the origin of the thymus?
What is the origin of the thymus?
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What does the 1st branchial groove form?
What does the 1st branchial groove form?
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What does the 1st branchial membrane form?
What does the 1st branchial membrane form?
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Where does the thyroid gland originate?
Where does the thyroid gland originate?
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What is the foramen caecum?
What is the foramen caecum?
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What can thyroglossal duct remnants lead to?
What can thyroglossal duct remnants lead to?
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What is the First Arch Syndrome?
What is the First Arch Syndrome?
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What is hypoplasia of the mandible and facial bones?
What is hypoplasia of the mandible and facial bones?
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What is a coloboma-type defect of the lower eyelid?
What is a coloboma-type defect of the lower eyelid?
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Ectopic Thyroid Tissue
Ectopic Thyroid Tissue
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Symptoms of Ectopic Thyroid Tissue
Symptoms of Ectopic Thyroid Tissue
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Hyperthyroidism and Ectopic Thyroid Tissue
Hyperthyroidism and Ectopic Thyroid Tissue
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Autoimmune Diseases and Ectopic Thyroid Tissue
Autoimmune Diseases and Ectopic Thyroid Tissue
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Lateral Cysts, Sinuses, and Fistulae
Lateral Cysts, Sinuses, and Fistulae
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Lateral Cysts
Lateral Cysts
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Lateral Sinuses
Lateral Sinuses
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Lateral Fistulae
Lateral Fistulae
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Study Notes
Pharyngeal Apparatus Development
- Pharyngeal apparatus development is complex, often involving multiple problems
- Fish use pharyngeal apparatus for extracting oxygen from water, humans retain this structure
- Pharyngeal arches develop during the fourth week and give rise to facial and neck structures
- Four to six pharyngeal arches are present, numbered 1-6 (5 in humans)
- Arches are supported by paraxial mesoderm and neural crest cells
- The arches are separated by grooves and clefts
- The arches derive from pouches (endoderm) and grooves (ectoderm)
- Arch arteries connect the aortic sac to the dorsal aortae, and will develop into blood vessels
- The mesenchymal core of the arches gives rise to tissues in the head and neck region
- Dermis (head and neck)
- Smooth muscle (neck)
- Skeletal elements (head)
- Striated muscle (facial expression and mastication)
- External ectoderm lining the arches
- Internal endoderm lining the pouches
Pharyngeal Arches
- Arches are numbered 1, 2, 3, 4, 6 (5 in humans)
- Arches are formed from paraxial mesoderm and neural crest cells
- Arcs contribute to the development of the face and neck
- Meckel's cartilage forms from the 1st arch and contributes to middle ear bones (malleus and incus)
- Reichert cartilage forms from the 2nd arch and contributes to stapes, stylohyoid ligament, and part of the hyoid bone
- The 3rd arch gives rise to the remaining hyoid bone
- The 4th and 6th arches do not form cartilages but instead develop into cartilages of the larynx
- Defects in development can lead to cleft palate and/or cleft lip.
Muscles from Pharyngeal Arches
- Muscles in the head and neck region develop from the pharyngeal arches
- The 1st arch contributes to masticatory muscles (temporalis, masseter, etc.) and parts of the digastricus, mylohyoid and tensor veli palatini muscles
- The 2nd arch forms muscles of facial expression and parts of the digastric, stylohyoid, and stapedius muscles
- Muscles of the 3rd arch form the stylopharyngeus muscle
- Muscles of the 4th and 6th arches form laryngeal muscles.
- Each arch muscle has specific nerve supply
Pharyngeal Pouches
- Pouches are endodermal invaginations
- Pouch 1 forms the tubotympanic recess (eustachian tube) and tympanic membrane
- Pouch 2 contributes to palatine tonsils (part of the Waldeyer's ring)
- Pouch 3 forms the thymus and inferior parathyroid glands
- Pouch 4 forms the superior parathyroid glands and parafollicular cells
- Pouch development is critical for the formation of the immune system
Pharyngeal Grooves/Clefts
- Grooves are ectodermal invaginations
- Groove 1 forms the external acoustic meatus
- Groove 1's membrane contributes the tympanic membrane
- The second and successive pharyngeal arches overlap, and their membranes disappear.
Development of the Face
- The face forms from five prominences: central frontonasal, 2 maxillary, and 2 mandibular.
- The nasal placodes form on the frontonasal prominence
- The medial nasal process forms the upper lip and intermaxillary segment
- The maxillary processes form the lateral upper lip
- The two medial nasal processes fuse to form the primary palate
Development of the Palate
- The palate is divided into primary and secondary palates
- Primary palate forms the anterior hard palate
- Secondary palate forms the posterior hard and soft palate
- The palatine shelves fuse to create a complete palate.
Clefts
- Clefts can occur if these processes don't fuse properly
- Cleft palate refers to defects in the palate
- Cleft lip refers to defects in the upper lip
- These deformities can be bilateral or unilateral
Development of the Thyroid Gland
- The thyroid forms as an outgrowth of the pharyngeal floor (endoderm)
- The thyroglossal duct connects the developing thyroid to the tongue
- The duct normally disappears
- Remnants of the duct can form cysts or ectopic thyroid tissue
- The thyroid gland secretes hormones responsible for metabolism
Development of Other Structures
- Certain abnormalities in the development of the pharyngeal apparatus could result in abnormal positions of the parathyroid, thymus or thyroid glands
- Structures are formed at specific times in development and from specific germ layers.
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