Pharmacology Unit: Drugs in Schizophrenia Case Study

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What is the time course of schizophrenia?

It manifests in middle age

It predominantly occurs in the elderly

It typically begins in late adolescence and early adulthood (correct)

It usually starts in childhood

Which type of drug is associated with extrapyramidal adverse effects?

2nd generation or 'Atypical' drugs

Anxiolytics

Antidepressants

1st generation or 'Typical' drugs (correct)

What kind of family history is significant for the female patient?

A history of anxiety disorders and cancer

A history of schizophrenia and depression

A history of schizophrenia, diabetes mellitus, and drug use (correct)

A history of bipolar disorder and substance abuse

What is the mode of action of 2nd generation or 'Atypical' drugs?

They mainly affect serotonin receptors Signup and view all the answers

What is responsible for half of long-term psychiatric hospitalizations?

Schizophrenia Signup and view all the answers

At what age does schizophrenia typically onset?

In late adolescence and early adulthood Signup and view all the answers

Which of the following is NOT a positive symptom of schizophrenia?

Social withdrawal Signup and view all the answers

What is the mode of action for most 2nd generation antipsychotics?

Serotonin receptor blockers Signup and view all the answers

Which drug has a relatively long clinical duration of action and can cause rapid severe relapse upon discontinuation?

Clozapine Signup and view all the answers

What is the primary function of the nigrostriatal dopaminergic pathway?

Coordination of voluntary movement Signup and view all the answers

Which receptor affinity is directly associated with the severity of extrapyramidal symptoms (EPS)?

[dopamine] receptors Signup and view all the answers

What is the primary effect of 5-HT 'antagonists' in atypical antipsychotics?

Modulation of release of various neurotransmitters Signup and view all the answers

Which antipsychotic drug exhibits a variable bioavailability range of 25% - 65%?

Quetiapine Signup and view all the answers

What is the main difference between typical and atypical antipsychotics in terms of receptor occupancy for efficacy?

>60% for typical antipsychotics and >80% for atypical antipsychotics. Signup and view all the answers

Which statement about the mesolimbic-mesocortical dopaminergic pathway is true?

[dopamine] increase in this pathway is closely related to behavioral changes and psychosis. Signup and view all the answers

What is the primary effect of partial D2 agonists in atypical antipsychotics?

Increased benefit for negative symptoms and improved cognition Signup and view all the answers

Pharmacology Unit: Drugs in Schizophrenia Case Study

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