Pharmacology Unit: Drugs in Schizophrenia Case Study
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Questions and Answers

What is the time course of schizophrenia?

  • It manifests in middle age
  • It predominantly occurs in the elderly
  • It typically begins in late adolescence and early adulthood (correct)
  • It usually starts in childhood

    • Which type of drug is associated with extrapyramidal adverse effects?

  • 2nd generation or 'Atypical' drugs
  • Anxiolytics
  • Antidepressants
  • 1st generation or 'Typical' drugs (correct)

    • What kind of family history is significant for the female patient?

  • A history of anxiety disorders and cancer
  • A history of schizophrenia and depression
  • A history of schizophrenia, diabetes mellitus, and drug use (correct)
  • A history of bipolar disorder and substance abuse

    • What is the mode of action of 2nd generation or 'Atypical' drugs?

    <p>They mainly affect serotonin receptors</p> Signup and view all the answers

    What is responsible for half of long-term psychiatric hospitalizations?

    <p>Schizophrenia</p> Signup and view all the answers

    At what age does schizophrenia typically onset?

    <p>In late adolescence and early adulthood</p> Signup and view all the answers

    Which of the following is NOT a positive symptom of schizophrenia?

    <p>Social withdrawal</p> Signup and view all the answers

    What is the mode of action for most 2nd generation antipsychotics?

    <p>Serotonin receptor blockers</p> Signup and view all the answers

    Which drug has a relatively long clinical duration of action and can cause rapid severe relapse upon discontinuation?

    <p>Clozapine</p> Signup and view all the answers

    What is the primary function of the nigrostriatal dopaminergic pathway?

    <p>Coordination of voluntary movement</p> Signup and view all the answers

    Which receptor affinity is directly associated with the severity of extrapyramidal symptoms (EPS)?

    <p>[dopamine] receptors</p> Signup and view all the answers

    What is the primary effect of 5-HT 'antagonists' in atypical antipsychotics?

    <p>Modulation of release of various neurotransmitters</p> Signup and view all the answers

    Which antipsychotic drug exhibits a variable bioavailability range of 25% - 65%?

    <p>Quetiapine</p> Signup and view all the answers

    What is the main difference between typical and atypical antipsychotics in terms of receptor occupancy for efficacy?

    <p>&gt;60% for typical antipsychotics and &gt;80% for atypical antipsychotics.</p> Signup and view all the answers

    Which statement about the mesolimbic-mesocortical dopaminergic pathway is true?

    <p>[dopamine] increase in this pathway is closely related to behavioral changes and psychosis.</p> Signup and view all the answers

    What is the primary effect of partial D2 agonists in atypical antipsychotics?

    <p>Increased benefit for negative symptoms and improved cognition</p> Signup and view all the answers

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