Pharmacology of β2 Agonists and Treatments
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Pharmacology of β2 Agonists and Treatments

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Questions and Answers

What is the recommended route of administration for high doses of β2 agonists?

  • Intravenous injection
  • Subcutaneous injection
  • Oral tablets
  • Inhalation (correct)
  • In cases of acidosis during treatment, which of the following is a recommended management strategy?

  • Administer intravenous fluids (correct)
  • Decrease magnesium sulfate dosage
  • Administer sodium bicarbonate orally
  • Increase oxygen therapy
  • What is the typical dosage range for intravenous magnesium sulfate in patients who have not responded to initial therapy?

  • 2-4 g over 1 hour
  • 0.5-1 g over 30 minutes
  • 1-1.5 g over 15 minutes
  • 1.2-2 g over 20 minutes (correct)
  • What is the normal range for arterial oxygen saturation (SaO2) in open air?

    <p>94-100%</p> Signup and view all the answers

    Which of the following interventions should be added to β2 agonists when necessary?

    <p>Ipratropium bromide by inhalation</p> Signup and view all the answers

    What physiological condition is indicated by a pH less than 7.34?

    <p>Acidosis</p> Signup and view all the answers

    What does an arterial blood gas (ABG) result with a PaO2 less than 80 mm Hg suggest?

    <p>Possible hypoxemia</p> Signup and view all the answers

    In oxygen therapy, what is the significance of maintaining a SaO2 above 94%?

    <p>Indicates sufficient oxygen delivery to tissues</p> Signup and view all the answers

    A pH level of 7.30 indicates alkalosis.

    <p>False</p> Signup and view all the answers

    Dehydration can be corrected by IV fluids in the management of respiratory conditions.

    <p>True</p> Signup and view all the answers

    The normal range for arterial oxygen saturation (SaO2) is 90-95%.

    <p>False</p> Signup and view all the answers

    Magnesium sulfate can be administered as a single dose intravenously in cases of severe respiratory distress if initial treatments fail.

    <p>True</p> Signup and view all the answers

    A PaO2 less than 80 mm Hg indicates that oxygen therapy is unnecessary.

    <p>False</p> Signup and view all the answers

    Ipratropium bromide should only be added to β2 agonist therapy for patients under 18 years old.

    <p>False</p> Signup and view all the answers

    A normal pH reading would typically be within the range of 7.34 to 7.40.

    <p>True</p> Signup and view all the answers

    High doses of β2 agonists are generally not administered via inhalation.

    <p>False</p> Signup and view all the answers

    What must be considered for patients who fail to respond to initial inhaled bronchodilator therapy?

    <p>A single dose of IV magnesium sulfate.</p> Signup and view all the answers

    In the management of respiratory conditions, how should dehydration be addressed?

    <p>By administering intravenous fluids.</p> Signup and view all the answers

    What role does ipratropium bromide play when used alongside β2 agonists?

    <p>It enhances the bronchodilator effect.</p> Signup and view all the answers

    What interpretation is made when arterial blood gas (ABG) reveals a pH level below 7.34?

    <p>It indicates acidosis and potential tissue hypoxia.</p> Signup and view all the answers

    What is the maximum allowed time for administering IV magnesium sulfate for respiratory distress?

    <p>Over 20 minutes.</p> Signup and view all the answers

    What value must PaO2 exceed in open-air conditions to ensure adequate oxygenation?

    <p>It must be greater than 80 mm Hg.</p> Signup and view all the answers

    What must be monitored to ensure effective oxygen therapy?

    <p>Oxygen saturation (SaO2) should be above 94%.</p> Signup and view all the answers

    In oxygen therapy, what is indicated by a SaO2 level of less than 94%?

    <p>The patient may require supplemental oxygen.</p> Signup and view all the answers

    The recommended route for administering high doses of β2 agonists is by ______.

    <p>inhalation</p> Signup and view all the answers

    Hydrocortisone is administered at a dosage of ______ mg every 6 hours.

    <p>200</p> Signup and view all the answers

    To correct dehydration and acidosis, ______ fluids are administered.

    <p>IV</p> Signup and view all the answers

    A normal arterial blood gas (ABG) pH value is typically between ______ and 7.44.

    <p>7.34</p> Signup and view all the answers

    Magnesium sulfate can be administered intravenously in a single dose of ______ to ______ grams.

    <p>1.2-2</p> Signup and view all the answers

    Arterial oxygen saturation must be greater than ______% in open air conditions.

    <p>94</p> Signup and view all the answers

    Ipratropium bromide should be added to β2 agonists if patients ______ to the initial treatment.

    <p>fail</p> Signup and view all the answers

    The interpretation of a pH level below 7.34 indicates ______.

    <p>acidosis</p> Signup and view all the answers

    Match the following treatments with their respective indications:

    <p>High-dose β2 agonists = Severe asthma exacerbation Ipratropium bromide = Add-on therapy for bronchodilation Magnesium sulfate = Rescue for unresponsive patients Hydrocortisone = Management of inflammation</p> Signup and view all the answers

    Match the following arterial blood gas parameters with their normal ranges:

    <p>pH = 7.34 – 7.44 Arterial O2 saturation = 94 – 100 % PaO2 = &gt;80 mm Hg HCO3- = 22 – 26 mEq/L</p> Signup and view all the answers

    Match the following pH interpretations with their conditions:

    <p>pH &lt; 7.34 = Acidosis pH &gt; 7.44 = Alkalosis pH between 7.34 and 7.40 = Normal balance pH &lt; 7.30 = Severe acidosis</p> Signup and view all the answers

    Match the following therapeutic measures with their timing or method:

    <p>IV fluids = Correction of dehydration Magnesium sulfate = Single dose in 20 minutes Hydrocortisone = Every 6 hours Oxygen therapy = Maintain SaO2 &gt; 94%</p> Signup and view all the answers

    Match the following drugs with their routes of administration:

    <p>β2 agonists = Inhalation Ipratropium bromide = Inhalation Hydrocortisone = IV Magnesium sulfate = IV</p> Signup and view all the answers

    Match the following clinical indicators with their respiratory implications:

    <p>SaO2 &lt; 94% = Risk of hypoxia PaO2 &lt; 80 mm Hg = Severe hypoxia Acidosis = Decreased O2 binding Alkalosis = Increased O2 binding</p> Signup and view all the answers

    Match the following conditions with their related treatments:

    <p>Severe asthma = β2 agonists and Ipratropium Respiratory acidosis = IV fluids for correction Unresponsive bronchospasm = Magnesium sulfate Severe inflammation = Hydrocortisone</p> Signup and view all the answers

    Match the following clinical scenarios with their primary interventions:

    <p>Initial bronchodilator failure = Add Ipratropium bromide Respiratory distress = Consider IV magnesium sulfate Acidosis management = Administer IV fluids Inflammatory exacerbation = Hydrocortisone treatment</p> Signup and view all the answers

    Study Notes

    β2 Agonists and Treatment Protocols

    • High doses of β2 agonists are administered via inhalation for effective bronchodilation.
    • Ipratropium bromide, an anticholinergic medication, is added through inhalation to enhance β2 agonist effects.
    • Hydrocortisone is given intravenously at a dosage of 200 mg every 6 hours to reduce inflammation.
    • Consider administering a single dose of intravenous magnesium sulfate (1.2-2 g) over 20 minutes for patients unresponsive to initial inhaled bronchodilator therapy.
    • Correction of acidosis and dehydration should be managed with intravenous fluids.

    Oxygen Therapy and Blood Gas Interpretation

    • Arterial blood gases (ABGs) are crucial for assessing oxygenation status and acid-base balance.
    • Normal pH range is from 7.34 to 7.44; deviations indicate acidosis or alkalosis:
      • Acidosis results in decreased O2 binding to hemoglobin, causing tissue hypoxia.
      • Alkalosis increases O2 binding to hemoglobin.
    • Normal arterial oxygen saturation (SaO2) ranges from 94% to 100%:
      • At open air, SaO2 should be above 94%.
      • Partial pressure of arterial oxygen (PaO2) must exceed 80 mm Hg (or 10.6 kPa) for adequate oxygenation.

    β2 Agonists and Treatment Protocols

    • High doses of β2 agonists are administered via inhalation for effective bronchodilation.
    • Ipratropium bromide, an anticholinergic medication, is added through inhalation to enhance β2 agonist effects.
    • Hydrocortisone is given intravenously at a dosage of 200 mg every 6 hours to reduce inflammation.
    • Consider administering a single dose of intravenous magnesium sulfate (1.2-2 g) over 20 minutes for patients unresponsive to initial inhaled bronchodilator therapy.
    • Correction of acidosis and dehydration should be managed with intravenous fluids.

    Oxygen Therapy and Blood Gas Interpretation

    • Arterial blood gases (ABGs) are crucial for assessing oxygenation status and acid-base balance.
    • Normal pH range is from 7.34 to 7.44; deviations indicate acidosis or alkalosis:
      • Acidosis results in decreased O2 binding to hemoglobin, causing tissue hypoxia.
      • Alkalosis increases O2 binding to hemoglobin.
    • Normal arterial oxygen saturation (SaO2) ranges from 94% to 100%:
      • At open air, SaO2 should be above 94%.
      • Partial pressure of arterial oxygen (PaO2) must exceed 80 mm Hg (or 10.6 kPa) for adequate oxygenation.

    β2 Agonists and Treatment Protocols

    • High doses of β2 agonists are administered via inhalation for effective bronchodilation.
    • Ipratropium bromide, an anticholinergic medication, is added through inhalation to enhance β2 agonist effects.
    • Hydrocortisone is given intravenously at a dosage of 200 mg every 6 hours to reduce inflammation.
    • Consider administering a single dose of intravenous magnesium sulfate (1.2-2 g) over 20 minutes for patients unresponsive to initial inhaled bronchodilator therapy.
    • Correction of acidosis and dehydration should be managed with intravenous fluids.

    Oxygen Therapy and Blood Gas Interpretation

    • Arterial blood gases (ABGs) are crucial for assessing oxygenation status and acid-base balance.
    • Normal pH range is from 7.34 to 7.44; deviations indicate acidosis or alkalosis:
      • Acidosis results in decreased O2 binding to hemoglobin, causing tissue hypoxia.
      • Alkalosis increases O2 binding to hemoglobin.
    • Normal arterial oxygen saturation (SaO2) ranges from 94% to 100%:
      • At open air, SaO2 should be above 94%.
      • Partial pressure of arterial oxygen (PaO2) must exceed 80 mm Hg (or 10.6 kPa) for adequate oxygenation.

    β2 Agonists and Treatment Protocols

    • High doses of β2 agonists are administered via inhalation for effective bronchodilation.
    • Ipratropium bromide, an anticholinergic medication, is added through inhalation to enhance β2 agonist effects.
    • Hydrocortisone is given intravenously at a dosage of 200 mg every 6 hours to reduce inflammation.
    • Consider administering a single dose of intravenous magnesium sulfate (1.2-2 g) over 20 minutes for patients unresponsive to initial inhaled bronchodilator therapy.
    • Correction of acidosis and dehydration should be managed with intravenous fluids.

    Oxygen Therapy and Blood Gas Interpretation

    • Arterial blood gases (ABGs) are crucial for assessing oxygenation status and acid-base balance.
    • Normal pH range is from 7.34 to 7.44; deviations indicate acidosis or alkalosis:
      • Acidosis results in decreased O2 binding to hemoglobin, causing tissue hypoxia.
      • Alkalosis increases O2 binding to hemoglobin.
    • Normal arterial oxygen saturation (SaO2) ranges from 94% to 100%:
      • At open air, SaO2 should be above 94%.
      • Partial pressure of arterial oxygen (PaO2) must exceed 80 mm Hg (or 10.6 kPa) for adequate oxygenation.

    β2 Agonists and Treatment Protocols

    • High doses of β2 agonists are administered via inhalation for effective bronchodilation.
    • Ipratropium bromide, an anticholinergic medication, is added through inhalation to enhance β2 agonist effects.
    • Hydrocortisone is given intravenously at a dosage of 200 mg every 6 hours to reduce inflammation.
    • Consider administering a single dose of intravenous magnesium sulfate (1.2-2 g) over 20 minutes for patients unresponsive to initial inhaled bronchodilator therapy.
    • Correction of acidosis and dehydration should be managed with intravenous fluids.

    Oxygen Therapy and Blood Gas Interpretation

    • Arterial blood gases (ABGs) are crucial for assessing oxygenation status and acid-base balance.
    • Normal pH range is from 7.34 to 7.44; deviations indicate acidosis or alkalosis:
      • Acidosis results in decreased O2 binding to hemoglobin, causing tissue hypoxia.
      • Alkalosis increases O2 binding to hemoglobin.
    • Normal arterial oxygen saturation (SaO2) ranges from 94% to 100%:
      • At open air, SaO2 should be above 94%.
      • Partial pressure of arterial oxygen (PaO2) must exceed 80 mm Hg (or 10.6 kPa) for adequate oxygenation.

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    Description

    This quiz explores the use of β2 agonists and additional medications such as ipratropium bromide and hydrocortisone. It discusses their administration via inhalation and intravenous methods, including magnesium sulfate for patients not responding to initial treatments. Test your knowledge on pharmacological interventions and protocols.

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