Pharmacology of Sympathomimetics

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Questions and Answers

What is a common adverse effect of selective β2 agonists?

  • Hypotension
  • Drowsiness
  • Tachycardia (correct)
  • Nausea

What action do β2 agonists primarily provide in the treatment of bronchial asthma?

  • Bronchodilation (correct)
  • Vasoconstriction
  • Diuresis
  • Sedation

What is the effect of ephedrine on CNS functioning?

  • Depression
  • Amnesia
  • Drowsiness
  • Euphoria (correct)

Which condition does ritodrine primarily treat?

<p>Preterm labour (B)</p> Signup and view all the answers

What phenomenon is associated with the use of amphetamines?

<p>Tolerance (D)</p> Signup and view all the answers

What is the main pharmacological action of mixed-acting sympathomimetics like ephedrine?

<p>Slower actions with longer duration (D)</p> Signup and view all the answers

What adverse effect might a patient experience due to excessive use of ephedrine?

<p>Urinary retention (A)</p> Signup and view all the answers

Which of the following is NOT a pharmacological action of β2 agonists?

<p>Uterine contraction (D)</p> Signup and view all the answers

What type of receptors do sympathomimetic drugs primarily target?

<p>Adrenergic receptors (B)</p> Signup and view all the answers

Which of the following statements is true regarding sympathomimetic drugs?

<p>They are rapidly metabolized by COMT and MAO. (A)</p> Signup and view all the answers

What effect does epinephrine have on the cardiovascular system?

<p>Increases force of cardiac contraction and heart rate (A)</p> Signup and view all the answers

Which adrenergic receptor is primarily responsible for vasoconstriction in skin and mucous membranes?

<p>α1 (A)</p> Signup and view all the answers

What effect does stimulation of β2 adrenergic receptors have in skeletal muscles?

<p>Vasodilation of skeletal muscle blood vessels (C)</p> Signup and view all the answers

What is the primary effect of α2 adrenergic receptor stimulation?

<p>Inhibition of norepinephrine release (C)</p> Signup and view all the answers

How does epinephrine affect diastolic blood pressure during α1 receptor stimulation?

<p>May show slight increase or decrease (C)</p> Signup and view all the answers

What is the main difference between catecholamines and non-catecholamines?

<p>Catecholamines are rapidly metabolized, non-catecholamines are not. (A)</p> Signup and view all the answers

What effect does β2 stimulation have on the diastolic blood pressure?

<p>Decrease diastolic blood pressure (C)</p> Signup and view all the answers

Which of the following is NOT a pharmacological action of norepinephrine?

<p>Stimulation of β2 adrenoceptors (B)</p> Signup and view all the answers

What is one therapeutic use of non-selective beta agonists like isoprenaline?

<p>Bronchodilatation in bronchial asthma (C)</p> Signup and view all the answers

What adverse effect is commonly associated with the use of beta agonists?

<p>Tachycardia (D)</p> Signup and view all the answers

Which agent is primarily used for treating hypotension by acting as an α1 selective agonist?

<p>Midodrine (C)</p> Signup and view all the answers

How does β2 stimulation affect the urinary bladder?

<p>Relaxes the bladder wall (D)</p> Signup and view all the answers

What is the primary purpose of using local anesthetic with a vasoconstrictor?

<p>To delay absorption and prolong duration (B)</p> Signup and view all the answers

In the case of severe vasoconstriction and potential gangrene from extravasation, what is the advised treatment?

<p>Intravenous phentolamine injection (A)</p> Signup and view all the answers

Flashcards

Sympathetic Nervous System

Part of the autonomic nervous system that prepares the body for "fight-or-flight" responses.

Parasympathetic Nervous System

Part of the autonomic nervous system that promotes "rest-and-digest" functions.

Neurotransmitter

Chemical messenger that transmits signals between neurons or from neurons to other cells.

Adrenergic Receptors

Receptors that bind to norepinephrine and epinephrine.

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Cholinergic Receptors

Receptors that bind to acetylcholine.

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Epinephrine (Adrenaline)

A hormone and neurotransmitter that triggers the fight-or-flight response.

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Sympathomimetics

Drugs that mimic the actions of epinephrine or norepinephrine.

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Sympatholytics

Drugs that block the effects of epinephrine or norepinephrine.

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Catecholamines

Group of neurotransmitters and hormones with similar chemical structures including norepinephrine, epinephrine & dopamine

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Non Catecholamines

Neurotransmitters and hormones that are not catecholamines.

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α1 receptors

Type of adrenergic receptor that cause vasoconstriction in certain blood vessels.

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β1 receptors

Type of adrenergic receptor that is found in the heart and increases cardiac output.

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β2 receptors

Type of adrenergic receptor that causes vasodilation in skeletal muscle blood vessles.

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β2 stimulation effect on blood vessels

Leads to vasodilation (widening of blood vessels) and a decrease in diastolic blood pressure.

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Selective β2 agonists

Drugs that primarily activate beta-2 adrenergic receptors.

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Salbutamol/Terbutaline

Short-acting beta-2 agonists used for asthma and preterm labour.

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β2 receptors effect on respiration

Causes bronchodilation (opening of airways) in the lungs.

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Formoterol/Salmeterol

Long-acting beta-2 agonists for maintenance asthma treatment.

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β2 receptors effect on GIT

Inhibits the tone and movement of the gastrointestinal tract and contracts sphincters.

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Ritodrine

Beta-2 agonist used to stop premature labor.

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β2 receptors effect on urinary bladder

Relaxes the bladder wall and contracts the sphincter to prevent involuntary urination.

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Mixed-Acting Sympathomimetics

Drugs with both direct and indirect effects on the sympathetic nervous system.

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β2 receptors effect on uterus

Causes relaxation of the uterus. Important during pregnancy.

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β2 receptors anti-allergic action

Acts as a physiological antidote to histamine; useful in managing allergic reactions.

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Ephedrine

A plant-based or synthetic sympathomimetic with both direct and indirect actions.

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Amphetamine

A stimulant that mainly affects the central nervous system, resulting in increased alertness and decreased appetite.

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α1 receptors on GI tract

Contracts sphincters in the gastrointestinal tract.

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Noradrenaline action on blood vessels

Causes vasoconstriction, especially in skin and mucous membrane, increasing peripheral resistance and blood pressure.

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Adverse effects of Sympathomimetics

Unwanted side effects like tachycardia, palpitations, anxiety, and tremors.

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Noradrenaline effect on the heart

Increases heart contractility but reflex vagal stimulation slows heart rate due to increased blood pressure.

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Isoprenaline's effect on blood vessels

Causes vasodilation in skeletal muscle and coronary blood vessels; lowers diastolic blood pressure.

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Isoprenaline's effect on bronchi

Promotes bronchodilation, important for treating bronchial asthma.

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Dobutamine's effect on the heart

Increases heart contractility, with minimal impact on heart rate. A selective β1 agonist.

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