Y1S2 005 II Pharmacology of Skeletal Muscle Systems
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Questions and Answers

What is the primary objective of the lecture on drugs acting on the skeletal muscle system?

  • To discuss the pathophysiology of muscle diseases
  • To discuss the physiology of the skeletal muscle system
  • To discuss the pharmacology of some drugs used to induce skeletal muscle paralysis, increase muscle strength, and treat Spastic disorders (correct)
  • To discuss the pharmacology of drugs used to treat neurological disorders

    • What type of channels are stimulated by the release of Ach in the muscle?

  • Gamma-aminobutyric acid (GABA) receptors
  • Nicotinic Na+ channels (correct)
  • Muscarinic K+ channels
  • Voltage-sensitive Ca2+ channels

    • What is the result of the stimulation of the channels by the neurotranmitter in the cleft?

  • Development of endplate potential (correct)
  • Inhibition of muscle contraction
  • Hyperpolarization of the muscle fiber
  • Stimulation of the muscle spindle

    • Through which channels is the depolarization propagated down the muscle?

    <p>Voltage-sensitive Na+ channels</p> Signup and view all the answers

    What is the name of the YouTube video linked in the text?

    <p>AP Propagation</p> Signup and view all the answers

    What is the email address of Professor M. Gossell-Williams?

    <p><a href="mailto:[email protected]">[email protected]</a></p> Signup and view all the answers

    What is the primary mechanism of action of succinylcholine?

    <p>Persistent depolarization of sodium channels</p> Signup and view all the answers

    Which of the following muscle relaxants is metabolized by pseudocholinesterases?

    <p>Mivacurium</p> Signup and view all the answers

    What is the primary clinical application of dantrolene?

    <p>To relieve spasticity in conditions such as cerebral palsy and multiple sclerosis</p> Signup and view all the answers

    What is the duration of action of mivacurium?

    <p>Ultrashort (5-10 minutes)</p> Signup and view all the answers

    What is the adverse effect of succinylcholine that results in uncontrolled skeletal muscle hypermetabolism?

    <p>Malignant hyperthermia</p> Signup and view all the answers

    What is the route of administration of pancuronium?

    <p>Intramuscular (IM) or intravenous (IV)</p> Signup and view all the answers

    What is the primary mechanism of action of Baclofen in preventing skeletal muscle excitation-contraction coupling?

    <p>GABA-B receptor agonism</p> Signup and view all the answers

    Which of the following medications is known to cause significant sedation?

    <p>Diazepam</p> Signup and view all the answers

    What is the primary route of administration for Baclofen?

    <p>Oral</p> Signup and view all the answers

    What is the primary mechanism of action of Pyridostigmine?

    <p>Reversible inhibition of acetylcholinesterase</p> Signup and view all the answers

    What is the primary elimination pathway for Pyridostigmine?

    <p>Renal excretion</p> Signup and view all the answers

    What is a common side effect of Dantrolene?

    <p>Hepatotoxicity</p> Signup and view all the answers

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