18 Questions
What is the primary objective of the lecture on drugs acting on the skeletal muscle system?
To discuss the pharmacology of some drugs used to induce skeletal muscle paralysis, increase muscle strength, and treat Spastic disorders
What type of channels are stimulated by the release of Ach in the muscle?
Nicotinic Na+ channels
What is the result of the stimulation of the channels by the neurotranmitter in the cleft?
Development of endplate potential
Through which channels is the depolarization propagated down the muscle?
Voltage-sensitive Na+ channels
What is the name of the YouTube video linked in the text?
AP Propagation
What is the primary mechanism of action of succinylcholine?
Persistent depolarization of sodium channels
Which of the following muscle relaxants is metabolized by pseudocholinesterases?
Mivacurium
What is the primary clinical application of dantrolene?
To relieve spasticity in conditions such as cerebral palsy and multiple sclerosis
What is the duration of action of mivacurium?
Ultrashort (5-10 minutes)
What is the adverse effect of succinylcholine that results in uncontrolled skeletal muscle hypermetabolism?
Malignant hyperthermia
What is the route of administration of pancuronium?
Intramuscular (IM) or intravenous (IV)
What is the primary mechanism of action of Baclofen in preventing skeletal muscle excitation-contraction coupling?
GABA-B receptor agonism
Which of the following medications is known to cause significant sedation?
Diazepam
What is the primary route of administration for Baclofen?
Oral
What is the primary mechanism of action of Pyridostigmine?
Reversible inhibition of acetylcholinesterase
What is the primary elimination pathway for Pyridostigmine?
Renal excretion
What is a common side effect of Dantrolene?
Hepatotoxicity
This quiz covers the pharmacology of drugs that affect the skeletal muscle system, including those that induce paralysis, increase muscle strength, and treat spastic disorders. It also explores the mechanism of action potential propagation in motor units. Test your knowledge of these concepts and more!
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