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Y1S2 005 I Pharmacology of Skeletal Muscle Systems

18 Questions

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Y1S2 005 I Pharmacology of Skeletal Muscle Systems

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Questions and Answers

What is the primary objective of the lecture on drugs acting on the skeletal muscle system?

To understand the anatomy of the skeletal muscle system

To investigate the role of genetics in muscle development

To discuss the pharmacology of drugs used to induce skeletal muscle paralysis, increase muscle strength, and treat Spastic disorders (correct)

To explain the physiology of muscle contraction

What type of channels are stimulated by the release of Ach in the neurotransmission process?

Nicotinic Na+ channels (correct)

Voltage-sensitive Ca2+ channels

Nicotinic K+ channels

Voltage-sensitive K+ channels

What is the result of the depolarization of the endplate potential?

Muscle relaxation

Neurotransmitter reuptake

Muscle contraction

AP propagation down the sarcolemma (correct)

What type of channels are responsible for AP propagation down the muscle?

Voltage-sensitive Na+ channels Signup and view all the answers

What is the role of the neurotranmitter in the neuromuscular junction?

To stimulate the development of endplate potential Signup and view all the answers

What is the outcome of the arrival of an action potential at the nerve terminal?

The release of the neurotransmitter called Ach Signup and view all the answers

What is the primary mechanism of action of Succinylcholine?

Persistent depolarization inhibiting the passage of action potential Signup and view all the answers

What is the route of administration for Pancuronium?

IM or IV Signup and view all the answers

What is the metabolism pathway of Mivacurium?

Pseudocholinesterases Signup and view all the answers

What is the clinical application of Dantrolene?

To relieve spasticity in cerebral palsy Signup and view all the answers

What is the adverse effect of Succinylcholine that leads to post-operative pain?

Muscle fasciculation Signup and view all the answers

What is the mechanism of action of Dantrolene?

Inhibiting the release of calcium from the sarcoplasmic reticulum Signup and view all the answers

What is the main action of Baclofen on motor neuron activation?

Reduce motor neuron activation Signup and view all the answers

What is the primary effect of Diazepam on motor neuron activation?

Decrease motor neuron activation Signup and view all the answers

What is the route of administration for Pyridostigmine?

Orally Signup and view all the answers

What is the main application of Pyridostigmine in clinical practice?

To improve muscle strength in myasthenia gravis Signup and view all the answers

What is a common side effect of Pyridostigmine?

Salivation Signup and view all the answers

What is the half-life of Diazepam?

60 hours Signup and view all the answers