Y1S2 005 I Pharmacology of Skeletal Muscle Systems

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Questions and Answers

What is the primary objective of the lecture on drugs acting on the skeletal muscle system?

  • To understand the anatomy of the skeletal muscle system
  • To investigate the role of genetics in muscle development
  • To discuss the pharmacology of drugs used to induce skeletal muscle paralysis, increase muscle strength, and treat Spastic disorders (correct)
  • To explain the physiology of muscle contraction

What type of channels are stimulated by the release of Ach in the neurotransmission process?

  • Nicotinic Na+ channels (correct)
  • Voltage-sensitive Ca2+ channels
  • Nicotinic K+ channels
  • Voltage-sensitive K+ channels

What is the result of the depolarization of the endplate potential?

  • Muscle relaxation
  • Neurotransmitter reuptake
  • Muscle contraction
  • AP propagation down the sarcolemma (correct)

What type of channels are responsible for AP propagation down the muscle?

<p>Voltage-sensitive Na+ channels (D)</p> Signup and view all the answers

What is the role of the neurotranmitter in the neuromuscular junction?

<p>To stimulate the development of endplate potential (A)</p> Signup and view all the answers

What is the outcome of the arrival of an action potential at the nerve terminal?

<p>The release of the neurotransmitter called Ach (D)</p> Signup and view all the answers

What is the primary mechanism of action of Succinylcholine?

<p>Persistent depolarization inhibiting the passage of action potential (D)</p> Signup and view all the answers

What is the route of administration for Pancuronium?

<p>IM or IV (C)</p> Signup and view all the answers

What is the metabolism pathway of Mivacurium?

<p>Pseudocholinesterases (D)</p> Signup and view all the answers

What is the clinical application of Dantrolene?

<p>To relieve spasticity in cerebral palsy (A)</p> Signup and view all the answers

What is the adverse effect of Succinylcholine that leads to post-operative pain?

<p>Muscle fasciculation (A)</p> Signup and view all the answers

What is the mechanism of action of Dantrolene?

<p>Inhibiting the release of calcium from the sarcoplasmic reticulum (A)</p> Signup and view all the answers

What is the main action of Baclofen on motor neuron activation?

<p>Reduce motor neuron activation (A)</p> Signup and view all the answers

What is the primary effect of Diazepam on motor neuron activation?

<p>Decrease motor neuron activation (D)</p> Signup and view all the answers

What is the route of administration for Pyridostigmine?

<p>Orally (D)</p> Signup and view all the answers

What is the main application of Pyridostigmine in clinical practice?

<p>To improve muscle strength in myasthenia gravis (D)</p> Signup and view all the answers

What is a common side effect of Pyridostigmine?

<p>Salivation (C)</p> Signup and view all the answers

What is the half-life of Diazepam?

<p>60 hours (C)</p> Signup and view all the answers

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