18 Questions
What is the primary objective of the lecture on drugs acting on the skeletal muscle system?
To discuss the pharmacology of drugs used to induce skeletal muscle paralysis, increase muscle strength, and treat Spastic disorders
What type of channels are stimulated by the release of Ach in the neurotransmission process?
Nicotinic Na+ channels
What is the result of the depolarization of the endplate potential?
AP propagation down the sarcolemma
What type of channels are responsible for AP propagation down the muscle?
Voltage-sensitive Na+ channels
What is the role of the neurotranmitter in the neuromuscular junction?
To stimulate the development of endplate potential
What is the outcome of the arrival of an action potential at the nerve terminal?
The release of the neurotransmitter called Ach
What is the primary mechanism of action of Succinylcholine?
Persistent depolarization inhibiting the passage of action potential
What is the route of administration for Pancuronium?
IM or IV
What is the metabolism pathway of Mivacurium?
Pseudocholinesterases
What is the clinical application of Dantrolene?
To relieve spasticity in cerebral palsy
What is the adverse effect of Succinylcholine that leads to post-operative pain?
Muscle fasciculation
What is the mechanism of action of Dantrolene?
Inhibiting the release of calcium from the sarcoplasmic reticulum
What is the main action of Baclofen on motor neuron activation?
Reduce motor neuron activation
What is the primary effect of Diazepam on motor neuron activation?
Decrease motor neuron activation
What is the route of administration for Pyridostigmine?
Orally
What is the main application of Pyridostigmine in clinical practice?
To improve muscle strength in myasthenia gravis
What is a common side effect of Pyridostigmine?
Salivation
What is the half-life of Diazepam?
60 hours
This quiz covers the pharmacology of drugs used to induce skeletal muscle paralysis, increase muscle strength, and treat spastic disorders. It also explores the mechanism of action potential propagation in motor units. Test your knowledge of these concepts and more!
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