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Y1S2 005 III Pharmacology of Skeletal Muscle Systems

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Y1S2 005 III Pharmacology of Skeletal Muscle Systems

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Questions and Answers

What is the primary function of the drugs used to induce skeletal muscle paralysis?

To increase muscle strength

To stimulate muscle contraction

To relax muscles during surgical procedures (correct)

To treat Spastic disorders

Which type of channels are stimulated by the release of Ach during AP propagation?

Voltage-sensitive K+ channels

Voltage-sensitive Ca2+ channels

Muscarinic receptors

Nicotinic Na+ channels (correct)

What is the term for the development of a potential difference across the muscle membrane during AP propagation?

Action potential

Threshold potential

Depolarization

Endplate potential (correct)

What is the primary mechanism of AP propagation down the muscle?

Through the stimulation of voltage-sensitive Na+ channels Signup and view all the answers

What is the role of the neurotranmitter released by the nerve during AP propagation?

To stimulate the development of endplate potential Signup and view all the answers

What is the term for the potential difference that stimulates the contraction of muscle fibers?

Threshold potential Signup and view all the answers

What is the primary mechanism of action of Succinylcholine?

Persistent depolarization inhibiting the passage of action potential through voltage sodium channel Signup and view all the answers

Which of the following muscle relaxants is metabolized by pseudocholinesterases?

Succinylcholine and Mivacurium Signup and view all the answers

What is the primary clinical application of Dantrolene?

To relieve the spasticity occurring with conditions such as cerebral palsy Signup and view all the answers

What is the duration of action of Mivacurium?

Ultra-short (5-10 minutes) Signup and view all the answers

What is the adverse effect of Succinylcholine that is associated with genetic disorder of skeletal muscle calcium regulation?

Malignant hyperthermia Signup and view all the answers

Which of the following is a non-depolarizing muscle relaxant?

Pancuronium Signup and view all the answers

What is the primary action of Baclofen at the pre-synaptic and post-synaptic receptors in the spinal cord?

Reduce motor neuron activation Signup and view all the answers

What is the primary route of administration for Dantrolene?

Oral Signup and view all the answers

What is the primary effect of Pyridostigmine on acetylcholinesterase?

Reversible inhibition Signup and view all the answers

What is the primary elimination route of Pyridostigmine?

Renal Signup and view all the answers

What is a common adverse effect of Diazepam?

Sedation Signup and view all the answers

What is the approximate half-life of Baclofen?

3-4 hours Signup and view all the answers