18 Questions
What is the primary function of the drugs used to induce skeletal muscle paralysis?
To relax muscles during surgical procedures
Which type of channels are stimulated by the release of Ach during AP propagation?
Nicotinic Na+ channels
What is the term for the development of a potential difference across the muscle membrane during AP propagation?
Endplate potential
What is the primary mechanism of AP propagation down the muscle?
Through the stimulation of voltage-sensitive Na+ channels
What is the role of the neurotranmitter released by the nerve during AP propagation?
To stimulate the development of endplate potential
What is the term for the potential difference that stimulates the contraction of muscle fibers?
Threshold potential
What is the primary mechanism of action of Succinylcholine?
Persistent depolarization inhibiting the passage of action potential through voltage sodium channel
Which of the following muscle relaxants is metabolized by pseudocholinesterases?
Succinylcholine and Mivacurium
What is the primary clinical application of Dantrolene?
To relieve the spasticity occurring with conditions such as cerebral palsy
What is the duration of action of Mivacurium?
Ultra-short (5-10 minutes)
What is the adverse effect of Succinylcholine that is associated with genetic disorder of skeletal muscle calcium regulation?
Malignant hyperthermia
Which of the following is a non-depolarizing muscle relaxant?
Pancuronium
What is the primary action of Baclofen at the pre-synaptic and post-synaptic receptors in the spinal cord?
Reduce motor neuron activation
What is the primary route of administration for Dantrolene?
Oral
What is the primary effect of Pyridostigmine on acetylcholinesterase?
Reversible inhibition
What is the primary elimination route of Pyridostigmine?
Renal
What is a common adverse effect of Diazepam?
Sedation
What is the approximate half-life of Baclofen?
3-4 hours
This quiz covers the pharmacology of drugs that affect the skeletal muscle system, including those that induce paralysis, increase muscle strength, and treat spastic disorders. Learn about the mechanisms of action of these drugs and how they interact with the motor unit and sarcolemma.
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