Y1S2 005 III Pharmacology of Skeletal Muscle Systems
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Questions and Answers

What is the primary function of the drugs used to induce skeletal muscle paralysis?

  • To increase muscle strength
  • To stimulate muscle contraction
  • To relax muscles during surgical procedures (correct)
  • To treat Spastic disorders

Which type of channels are stimulated by the release of Ach during AP propagation?

  • Voltage-sensitive K+ channels
  • Voltage-sensitive Ca2+ channels
  • Muscarinic receptors
  • Nicotinic Na+ channels (correct)

What is the term for the development of a potential difference across the muscle membrane during AP propagation?

  • Action potential
  • Threshold potential
  • Depolarization
  • Endplate potential (correct)

What is the primary mechanism of AP propagation down the muscle?

<p>Through the stimulation of voltage-sensitive Na+ channels (B)</p> Signup and view all the answers

What is the role of the neurotranmitter released by the nerve during AP propagation?

<p>To stimulate the development of endplate potential (D)</p> Signup and view all the answers

What is the term for the potential difference that stimulates the contraction of muscle fibers?

<p>Threshold potential (D)</p> Signup and view all the answers

What is the primary mechanism of action of Succinylcholine?

<p>Persistent depolarization inhibiting the passage of action potential through voltage sodium channel (B)</p> Signup and view all the answers

Which of the following muscle relaxants is metabolized by pseudocholinesterases?

<p>Succinylcholine and Mivacurium (C)</p> Signup and view all the answers

What is the primary clinical application of Dantrolene?

<p>To relieve the spasticity occurring with conditions such as cerebral palsy (D)</p> Signup and view all the answers

What is the duration of action of Mivacurium?

<p>Ultra-short (5-10 minutes) (C)</p> Signup and view all the answers

What is the adverse effect of Succinylcholine that is associated with genetic disorder of skeletal muscle calcium regulation?

<p>Malignant hyperthermia (A)</p> Signup and view all the answers

Which of the following is a non-depolarizing muscle relaxant?

<p>Pancuronium (A)</p> Signup and view all the answers

What is the primary action of Baclofen at the pre-synaptic and post-synaptic receptors in the spinal cord?

<p>Reduce motor neuron activation (A)</p> Signup and view all the answers

What is the primary route of administration for Dantrolene?

<p>Oral (C)</p> Signup and view all the answers

What is the primary effect of Pyridostigmine on acetylcholinesterase?

<p>Reversible inhibition (D)</p> Signup and view all the answers

What is the primary elimination route of Pyridostigmine?

<p>Renal (D)</p> Signup and view all the answers

What is a common adverse effect of Diazepam?

<p>Sedation (B)</p> Signup and view all the answers

What is the approximate half-life of Baclofen?

<p>3-4 hours (A)</p> Signup and view all the answers

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