Pharmacology of Skeletal Muscle Disorders

Play an AI-generated podcast conversation about this lesson

Which condition is characterized by permanent movement disorders caused by abnormal development or damage to parts of the brain that control movement?

Muscular dystrophy

Amyotrophic lateral sclerosis

Cerebral palsy (correct)

Fibromyalgia

What is the progressive condition that affects motor neurons in the brain and spinal cord?

Muscular dystrophy

Amyotrophic lateral sclerosis (correct)

Cerebral palsy

Fibromyalgia

Which drug class is commonly used to manage Myasthenia gravis?

Anticholinesterases (correct)

Antibiotics

Anticoagulants

Diuretics

What type of drugs are used in the treatment of Myasthenia gravis?

Anticholinesterases Signup and view all the answers

Which skeletal muscle disorder is characterized by muscle diseases that weaken the musculoskeletal system?

Muscular dystrophy Signup and view all the answers

Which agent is a GABAB receptor agonist used to treat spastic diplegia?

Baclofen Signup and view all the answers

What drug is specifically used for the diagnosis of Myasthenia gravis?

Edrophonium Signup and view all the answers

How is Baclofen mainly excreted from the body?

Through the kidneys Signup and view all the answers

What is a common adverse effect of Baclofen?

Sedation and drowsiness Signup and view all the answers

Which agent potentiates GABA effects and is metabolised by Cytochrome P450?

Diazepam Signup and view all the answers

What may happen with high doses of benzodiazepines like Diazepam when administered with other sedatives?

Fatal outcome Signup and view all the answers

Which agent is a centrally acting alpha-2 agonist used to treat spasticity?

Tizanidine Signup and view all the answers

Which medication has a duration of action of 30 minutes to 2 hours?

Neostigmine Signup and view all the answers

Why is neostigmine contraindicated in cases of intestinal or urinary bladder obstruction?

It promotes bladder and GI tract motility Signup and view all the answers

Which condition is characterized by antibodies generated against Ca2+ channels?

Lambert Eaton Myasthenic Syndrome Signup and view all the answers

Which medication is used in the chronic management of myasthenia gravis and has a longer duration of action than neostigmine?

Pyridostigmine Signup and view all the answers

What is the primary therapeutic use of neostigmine?

Managing myasthenia gravis symptoms Signup and view all the answers

Which medication can be considered an antidote for neuromuscular junction blocking drugs?