Drugs Acting on the Skeletal Muscle Systems Quiz
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Questions and Answers

Which enzyme terminates the action of the neurotransmitter acetylcholine?

  • Cholinesterase
  • Acetylcholinesterase (correct)
  • Renalase
  • Pseudocholinesterase

What is the clinical application of drugs such as Succinylcholine and Pancuronium?

  • To produce muscle relaxation during general anaesthesia and endotracheal intubation. (correct)
  • To induce muscle fasciculation and postoperative pain.
  • To relieve the spasticity occurring with conditions such as cerebral palsy, multiple sclerosis, spinal cord injury, stroke.
  • To inhibit the release of Ca2+ from the sarcoplasmic reticulum.

What is the route of administration for drugs such as Succinylcholine, Mivacurium, and Pancuronium?

  • Intranasal (IN) or Oral (PO)
  • Subcutaneous (SC) or Intravascular (IV)
  • Intrathecal (IT) or Sublingual (SL)
  • Intramuscular (IM) or Intravenous (IV) (correct)

What is the duration of action of Succinylcholine and Mivacurium?

<p>Ultra-short (5-10 mins) (C)</p> Signup and view all the answers

Which drug in the text is a skeletal muscle relaxant used to relieve spasticity in conditions such as cerebral palsy, multiple sclerosis, spinal cord injury, and stroke?

<p>Dantrolene (A)</p> Signup and view all the answers

What type of blockade does the drug Pancuronium exert on the nicotinic receptor?

<p>Competitive blockade (A)</p> Signup and view all the answers

What is the primary purpose of the lecture on drugs acting on the skeletal muscle system?

<p>To discuss the pharmacology of some of drugs used to induce skeletal muscle paralysis, increase muscle strength, and treat Spastic disorders (A)</p> Signup and view all the answers

What is the mechanism of action of the released neurotransmitter in the development of endplate potential?

<p>Stimulation of nicotinic Na+ channels (B)</p> Signup and view all the answers

What is the site of action of the neurotransmitter that stimulates the development of endplate potential?

<p>Cleft (A)</p> Signup and view all the answers

What is responsible for creating the threshold potential in the muscle fibre?

<p>Stimulation of voltage sensitive Na+ channels (D)</p> Signup and view all the answers

What is the effect of the action potential on the muscle fibre?

<p>Depolarisation of the sarcolemma (D)</p> Signup and view all the answers

What is the channel responsible for the propagation of the action potential down the muscle fibre?

<p>Voltage sensitive Na+ channels (B)</p> Signup and view all the answers

What is the primary mechanism of action of Baclofen in reducing motor neuron activation?

<p>Activation of pre-synaptic and post-synaptic GABA-B receptors in the spinal cord (B)</p> Signup and view all the answers

What is the primary route of administration for Baclofen?

<p>Oral (B)</p> Signup and view all the answers

What is a common adverse effect of Dantrolene?

<p>Hepatotoxicity (D)</p> Signup and view all the answers

What is the mechanism of action of Pyridostigmine?

<p>Reversible inhibition of acetylcholinesterase (D)</p> Signup and view all the answers

What is the primary clinical application of Pyridostigmine?

<p>Treatment of myasthenia gravis (B)</p> Signup and view all the answers

What is the elimination pathway of Pyridostigmine?

<p>Renal elimination (D)</p> Signup and view all the answers
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