18 Questions
Which enzyme terminates the action of the neurotransmitter acetylcholine?
Acetylcholinesterase
What is the clinical application of drugs such as Succinylcholine and Pancuronium?
To produce muscle relaxation during general anaesthesia and endotracheal intubation.
What is the route of administration for drugs such as Succinylcholine, Mivacurium, and Pancuronium?
Intramuscular (IM) or Intravenous (IV)
What is the duration of action of Succinylcholine and Mivacurium?
Ultra-short (5-10 mins)
Which drug in the text is a skeletal muscle relaxant used to relieve spasticity in conditions such as cerebral palsy, multiple sclerosis, spinal cord injury, and stroke?
Dantrolene
What type of blockade does the drug Pancuronium exert on the nicotinic receptor?
Competitive blockade
What is the primary purpose of the lecture on drugs acting on the skeletal muscle system?
To discuss the pharmacology of some of drugs used to induce skeletal muscle paralysis, increase muscle strength, and treat Spastic disorders
What is the mechanism of action of the released neurotransmitter in the development of endplate potential?
Stimulation of nicotinic Na+ channels
What is the site of action of the neurotransmitter that stimulates the development of endplate potential?
Cleft
What is responsible for creating the threshold potential in the muscle fibre?
Stimulation of voltage sensitive Na+ channels
What is the effect of the action potential on the muscle fibre?
Depolarisation of the sarcolemma
What is the channel responsible for the propagation of the action potential down the muscle fibre?
Voltage sensitive Na+ channels
What is the primary mechanism of action of Baclofen in reducing motor neuron activation?
Activation of pre-synaptic and post-synaptic GABA-B receptors in the spinal cord
What is the primary route of administration for Baclofen?
Oral
What is a common adverse effect of Dantrolene?
Hepatotoxicity
What is the mechanism of action of Pyridostigmine?
Reversible inhibition of acetylcholinesterase
What is the primary clinical application of Pyridostigmine?
Treatment of myasthenia gravis
What is the elimination pathway of Pyridostigmine?
Renal elimination
Test your knowledge on the pharmacology of drugs used to induce skeletal muscle paralysis, increase muscle strength, and treat spastic disorders. Questions may cover drug mechanisms, effects, and applications in the context of skeletal muscle function.
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