Podcast
Questions and Answers
Which adverse effect is associated with Ethosuximide use for epilepsy?
Which adverse effect is associated with Ethosuximide use for epilepsy?
What is a potential risk of using Valproate during pregnancy?
What is a potential risk of using Valproate during pregnancy?
Which medication is indicated for the treatment of bipolar disorder?
Which medication is indicated for the treatment of bipolar disorder?
What is a common neurological side effect of the medication Ethosuximide?
What is a common neurological side effect of the medication Ethosuximide?
Signup and view all the answers
Which of the following conditions is contraindicated with the use of Phenytoin?
Which of the following conditions is contraindicated with the use of Phenytoin?
Signup and view all the answers
Which condition might indicate the use of Valproate for treatment?
Which condition might indicate the use of Valproate for treatment?
Signup and view all the answers
What is the primary mechanism of action for Carbamazepine?
What is the primary mechanism of action for Carbamazepine?
Signup and view all the answers
Which of these side effects is NOT typically associated with Valproate treatment?
Which of these side effects is NOT typically associated with Valproate treatment?
Signup and view all the answers
What is a significant concern when discontinuing Carbamazepine suddenly?
What is a significant concern when discontinuing Carbamazepine suddenly?
Signup and view all the answers
Which patient group should be monitored closely when prescribed Ethosuximide?
Which patient group should be monitored closely when prescribed Ethosuximide?
Signup and view all the answers
Which medication is associated with migraine prophylaxis?
Which medication is associated with migraine prophylaxis?
Signup and view all the answers
What condition is primarily treated with Gabapentin?
What condition is primarily treated with Gabapentin?
Signup and view all the answers
Which of the following is NOT typically a use for Pregabalin?
Which of the following is NOT typically a use for Pregabalin?
Signup and view all the answers
What is a characteristic of medications used in seizure management?
What is a characteristic of medications used in seizure management?
Signup and view all the answers
Which drug has a partial agonist indication in seizure treatment?
Which drug has a partial agonist indication in seizure treatment?
Signup and view all the answers
Which drug is classified as an α1 agonist for nasal decongestion?
Which drug is classified as an α1 agonist for nasal decongestion?
Signup and view all the answers
Which medication primarily acts on β1 receptors and is used in cases of cardiogenic shock?
Which medication primarily acts on β1 receptors and is used in cases of cardiogenic shock?
Signup and view all the answers
Which category of drug commonly used for allergic rhinitis is known for having both oral and topical administration routes?
Which category of drug commonly used for allergic rhinitis is known for having both oral and topical administration routes?
Signup and view all the answers
What is the mechanism of action for Clonidine in managing blood pressure?
What is the mechanism of action for Clonidine in managing blood pressure?
Signup and view all the answers
Which medication is indicated primarily for treating hyperadrenergic states?
Which medication is indicated primarily for treating hyperadrenergic states?
Signup and view all the answers
Identify the α1 antagonist used primarily to manage hypertension.
Identify the α1 antagonist used primarily to manage hypertension.
Signup and view all the answers
Which drug is specifically utilized for its selective β2 agonist properties in asthmatic patients?
Which drug is specifically utilized for its selective β2 agonist properties in asthmatic patients?
Signup and view all the answers
Which medication would be prescribed to reduce the hyperactive sympathetic response in patients experiencing pheochromocytoma?
Which medication would be prescribed to reduce the hyperactive sympathetic response in patients experiencing pheochromocytoma?
Signup and view all the answers
Which drug acts as a mixed-action sympathomimetic indicated for ADHD?
Which drug acts as a mixed-action sympathomimetic indicated for ADHD?
Signup and view all the answers
Which α2 agonist is often used for its sedative effects in managing opioid withdrawal?
Which α2 agonist is often used for its sedative effects in managing opioid withdrawal?
Signup and view all the answers
What differentiates the action of Ritodrine from typical β agonists?
What differentiates the action of Ritodrine from typical β agonists?
Signup and view all the answers
Which drug listed has been widely used for treating acute hypotensive states?
Which drug listed has been widely used for treating acute hypotensive states?
Signup and view all the answers
Identify the primary action of Doxazosin when treating urinary symptoms in benign prostatic hyperplasia.
Identify the primary action of Doxazosin when treating urinary symptoms in benign prostatic hyperplasia.
Signup and view all the answers
What effect does epinephrine have at high doses?
What effect does epinephrine have at high doses?
Signup and view all the answers
Which receptor is primarily stimulated by dopamine at small doses?
Which receptor is primarily stimulated by dopamine at small doses?
Signup and view all the answers
What is a potential consequence of using norepinephrine in the treatment of shock?
What is a potential consequence of using norepinephrine in the treatment of shock?
Signup and view all the answers
What role does epinephrine play in anaphylaxis management?
What role does epinephrine play in anaphylaxis management?
Signup and view all the answers
Which action does beta-2 adrenergic stimulation NOT contribute to?
Which action does beta-2 adrenergic stimulation NOT contribute to?
Signup and view all the answers
In what situation might the administration of nasal decongestants pose a risk?
In what situation might the administration of nasal decongestants pose a risk?
Signup and view all the answers
What mechanism is primarily involved in the action of catecholamines on cardiac tissue?
What mechanism is primarily involved in the action of catecholamines on cardiac tissue?
Signup and view all the answers
What is a typical side effect of adrenergic agonists like epinephrine?
What is a typical side effect of adrenergic agonists like epinephrine?
Signup and view all the answers
What physiological effect does norepinephrine have on blood vessels?
What physiological effect does norepinephrine have on blood vessels?
Signup and view all the answers
What is the result of excessive alpha-1 adrenergic receptor stimulation?
What is the result of excessive alpha-1 adrenergic receptor stimulation?
Signup and view all the answers
How do beta-2 agonists typically affect the gastrointestinal tract?
How do beta-2 agonists typically affect the gastrointestinal tract?
Signup and view all the answers
What complication can arise from the use of high-dose epinephrine in cardiac arrest?
What complication can arise from the use of high-dose epinephrine in cardiac arrest?
Signup and view all the answers
What is one of the primary therapeutic purposes of catecholamines in emergency medicine?
What is one of the primary therapeutic purposes of catecholamines in emergency medicine?
Signup and view all the answers
Which neurotransmitter does Mirtaapine primarily antagonize?
Which neurotransmitter does Mirtaapine primarily antagonize?
Signup and view all the answers
What is a common side effect associated with Lithium?
What is a common side effect associated with Lithium?
Signup and view all the answers
Oxcarbazepine affects what receptor to exert its antidepressant effects?
Oxcarbazepine affects what receptor to exert its antidepressant effects?
Signup and view all the answers
What type of drug is Agomelatine?
What type of drug is Agomelatine?
Signup and view all the answers
Which receptor does Olanzapine predominantly antagonize?
Which receptor does Olanzapine predominantly antagonize?
Signup and view all the answers
What mechanism do Benzodiazepines primarily use to enhance their effects?
What mechanism do Benzodiazepines primarily use to enhance their effects?
Signup and view all the answers
Which of the following is noted as a side effect of Valproate?
Which of the following is noted as a side effect of Valproate?
Signup and view all the answers
What is the main clinical use of Lithium?
What is the main clinical use of Lithium?
Signup and view all the answers
Which drug class does Trazoone belong to?
Which drug class does Trazoone belong to?
Signup and view all the answers
What mechanism does Lamotrigine utilize in epilepsy treatment?
What mechanism does Lamotrigine utilize in epilepsy treatment?
Signup and view all the answers
What is one effect associated with the use of Agomelatine?
What is one effect associated with the use of Agomelatine?
Signup and view all the answers
Risperidone is primarily used to treat which of the following disorders?
Risperidone is primarily used to treat which of the following disorders?
Signup and view all the answers
Which of the following drugs is most associated with hepatotoxicity?
Which of the following drugs is most associated with hepatotoxicity?
Signup and view all the answers
Which medication is known to induce metabolic side effects such as weight gain and diabetes?
Which medication is known to induce metabolic side effects such as weight gain and diabetes?
Signup and view all the answers
Study Notes
Bipolar (Carb a) / Mania c-depressive
- Drug: Lithium
- Route: Oral
- Dosing: 6 months if >2 years of treatment
-
Side Effects:
- Neuropathic pain
- Hirsutism, megaloblastic anemia, fetal malformation, hypersensitivity
-
Stopping Treatment:
- If no seizures, stop treatment
- If seizures, Stop treatment for 6 months, then continue therapy
Epilepsy (Ø seizure)
- Drug: Ethosuximide
- Route: Oral
- Mechanism of Action: Inhibits CA2+ channel
-
Side Effects:
- Nausea
- Anorexia, Lethargy, Dizziness, Hypersensitivity
Epilepsy (infantile/tonic-clonic/myodes)
- Drug: Valproate, Depakine
- Route: Oral
- Duration: 15h
-
Side Effects:
- Nausea, hair loss, weight gain, fetal weakness
- Pregnant = spina bifida!!
Adrenaline / Epinephrine
- Route: IV, SC, IM, inhalation,
-
Mechanism of Action: Catecholamine; adrenergic
- β1: Cardiovasc; vasoconstriction (high doses)
- α: (high doses)
- β2: (low doses)
-
Side Effects:
- Panic, anxiety, tremor, cerebrovascular
- Arrhythmias (haemorrhages)
- ↑ HR, BP, systolic contraction
-
Contraindications:
- Heart block
- Anaesthesia
- Angio-edema (allergy)
NA / NE
- Route: IV, IM
-
Mechanism of Action: Agonist
- α: vasoconstriction
- β:
-
Side Effects:
- Tachycardia
- Arrhythmias (necrosis/bleeding)
- Hyperthermia (necrosis/bleeding)
- Topical nasal decongestant
-
Contraindications:
- Local bleeding
- HypoT
- Anaphylactic shock
- ↓ GI motility
Dopamine
- Mechanism of Action: Small doses = D1 receptor
-
Side Effects:
- Vasodilation
Alpha 1 Adrenergic Agonists
- Naphfazoline - Used for topical vasoconstriction of the eye and nose.
- Phenylephrine - Used for nasal decongestion, cold symptoms, and topical vasoconstriction of the eye and nose.
- Pseudoephedrine - Used for cold symptoms, allergic rhinitis, and as a component in combination antihistamine/antitussive/NSAID formulations.
- Oxymetazoline - Used for nasal decongestion.
- Xylometazoline - Used for nasal decongestion and cough relief.
- Phenylephrine - Used for hypotensive shock, sinusitis, and as a component in combination antihistamine/antitussive/NSAID formulations.
Alpha 1 Adrenergic Antagonists
- Phenoxybenzamine - Used for treatment of pheochromocytoma (tumor of the adrenal medulla) and as a α-adrenergic antagonist to control blood pressure.
- Phentolamine - Used to treat hypertensive crisis, particularly in patients with pheochromocytoma.
- Prazosin - Used for hypertension and can cause orthostatic hypotension and tachycardia.
- Doxazosin - Used for severe hypertension.
- Terazosin - Used for hypertension.
- Tamsulosin - Used for benign prostatic hypertrophy and can impair ejaculation.
- Yohimbine - Used as a selective α2-adrenergic antagonist.
- Idazoxan - Used as a selective α2-adrenergic antagonist.
Alpha 2 Adrenergic Agonists
- Clonidine - Used for opioid/alcohol withdrawal, hypertension, and as an antihypertensive agent. It can cause orthostatic hypotension, bradycardia, dry mouth, and drowsiness.
- Ergot amines - Used as α2-adrenergic receptor blockers for migraines and cluster headaches.
Beta 1 Adrenergic Agonists
- Dobutamine - Used to treat cardiogenic shock.
Beta 2 Adrenergic Agonists
- Salbutamol - A short-acting (2-6 hours) β2-adrenergic agonist used for bronchial asthma.
- Terbutaline - A β2-adrenergic agonist that can be used for asthma and preterm labor.
- Salmeterol - A long-acting β2-adrenergic agonist used for asthma.
- Ritonodrine - A β2-adrenergic agonist that can be used for preterm labor and uterine relaxation.
- Mirabegron - A β2-adrenergic agonist for bladder relaxation.
- Ephedrine - A mixed acting α/β agonist used as a nasal decongestant (in combination with other medications) and for allergic rhinitis. It has a high rate of CNS effects and can cause tachycardia, hypertension, and can interact with MAOIs.
Mixed Acting Alpha/Beta Agonists
- Amphetamine - Used for ADHD, narcolepsy, and epilepsy. It can cause euphoria, talkativeness, and increased physical activity. It is also used as a performance enhancer and has a high potential for abuse.
Other Drugs
- Phentanolamine - An ergot derivative, used as an α-adrenergic antagonist and can cause orthostatic hypotension.
Medications for Psychiatric Disorders
- St. John's Wort is used for anxiety, depression, and hyperforin is the active ingredient.
- St. John's Wort inhibits the reuptake of serotonin, dopamine, norepinephrine, GABA, and glutamate.
- Mirtazapine is an antidepressant that blocks alpha-2 adrenergic, 5HT2C, and H1 receptors.
- Trazodone is an antidepressant. It blocks 5-HT2A, 5-HT2C, and does not affect serotonin reuptake.
- Agomelatine is an antidepressant used for severe depression, circadian disturbances, and is a melatonin agonist.
- Agomelatine is an antagonist of MT1 and MT2 receptors.
- Lithium salts are used for bipolar disorder, Alzheimer’s disease, and are commonly prescribed to reduce the incidence of suicidal behavior.
- Lithium salts increase the release of norepinephrine and serotonin.
- Lithium salts are associated with gastrointestinal discomfort, nausea, vomiting, diarrhea, anorexia, weight gain, polyuria, and tremor.
- Lithium salts can cause thyroid/kidney disorders or fetal malformations.
- Oxcarbazepine is used for bipolar depression, epilepsy, and is an enzyme inducer that reduces side effects.
- Valproate is used for epilepsy and is a teratogen.
- Lamotrigine is used for Epilepsy and is also a teratogen which prevents recurrence of seizures.
- Olanzapine is an anti-psychotic which functions as an antagonist of D2 and 5HT2A receptors.
- Risperidone is an anti-psychotic which functions as an antagonist of D2 and 5HT2A receptors.
- Quetiapine is an anti-psychotic used for schizophrenia, bipolar disorder.
- Aripiprazole is an anti-psychotic used for mania and bipolar disorder.
- Fluoxetine (SSRI) is an anti-psychotic used for mania and bipolar disorder.
- Haloperidol is used as a prophylactic for manic depression and anxiety disorders.
- Benzodiazepines (BZD) are used for anxiety, epilepsy, and are lipophilic, GABA-A receptor selective, and reduce anxiety but can be fatal.
- Gabapentin is used for epilepsy and is a GABA analogue, but does not interact with GABA receptors.
- Gabapentin is a teratogen.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Related Documents
Description
This quiz covers the pharmacological treatments for bipolar disorder and various types of epilepsy. It includes information on medications such as Lithium, Ethosuximide, and Valproate, along with their routes of administration, side effects, and mechanisms of action. Test your knowledge on these essential psychiatric and neurological drugs.