Pharmacology 2

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Questions and Answers

Can cause massive ______ damage - report any signs like muscle aches or weakness or dark urine.

kidney

Kawasaki Disease is an acute systemic ______ that can cause MI or aneurysms.

vasculitis

The drug of choice for SVT is ______.

adenosine

Digoxin toxicity is an issue; the good range is ______ - 2.

<p>0.5</p> Signup and view all the answers

Most antiHTN, antipsychotics, and antidepressants are considered ______ risk drugs.

<p>fall</p> Signup and view all the answers

Thrombolytic agents and tPA dissolve ______, but bleeding is a huge risk!

<p>thrombus</p> Signup and view all the answers

Dabigatran is a type of ______ inhibitor that reduces the risk of clot formation in stroke clients with Afib.

<p>thrombin</p> Signup and view all the answers

Do not give Adensosine unless the heart rhythm is greater than ______ bpm.

<p>150</p> Signup and view all the answers

Factor Xa inhibitors include ______, rivaroxaban, and dabigatran.

<p>apixaban</p> Signup and view all the answers

Spironolactone is a potassium sparing ______ that works to save potassium when used with thiazide diuretics.

<p>diuretic</p> Signup and view all the answers

Furosemide is a loop diuretic that is great for heart ______.

<p>failure</p> Signup and view all the answers

Thiazide diuretics can cause hypokalemia and ______.

<p>hyponatremia</p> Signup and view all the answers

Milrinone is used to increase contractility and promote ______ in heart failure patients.

<p>vasodilation</p> Signup and view all the answers

Report any signs of infection because these cause __________.

<p>immunosuppression</p> Signup and view all the answers

Prednisone can cause hyperglycemia; therefore, it is important to check ______ regularly.

<p>blood glucose</p> Signup and view all the answers

Desmopressin is a synthetic form of ______ that treats diabetes insipidus (DI).

<p>ADH</p> Signup and view all the answers

An increase in thirst, hunger, and urination may indicate __________.

<p>hyperglycemia</p> Signup and view all the answers

Radioactive Iodine therapy treats hyperthyroid disorders and destroys thyroid ______.

<p>tissue</p> Signup and view all the answers

Regular insulin is the only insulin that can be administered __________.

<p>IV push</p> Signup and view all the answers

Insulin pumps provide better control of consistent blood ______.

<p>glucose</p> Signup and view all the answers

Glarine should never be mixed with another insulin in a __________.

<p>syringe</p> Signup and view all the answers

Levothyroxine is used for treating __________.

<p>hypothyroidism</p> Signup and view all the answers

Sulfonylurea medications, such as glyburide, are used for ______ management.

<p>diabetes</p> Signup and view all the answers

Sulfonylureas and tricyclic antidepressants are on the Beers Criteria list for __________ individuals.

<p>old</p> Signup and view all the answers

Thiazolidinediones can worsen heart rate by causing __________ retention.

<p>fluid</p> Signup and view all the answers

Metformin increases the sensitivity of __________ receptors.

<p>insulin</p> Signup and view all the answers

Proton Pump Inhibitors are great for peptic ulcer disease and __________.

<p>GERD</p> Signup and view all the answers

Dicyclomine hydrochloride is an anticholinergic that treats __________.

<p>IBS</p> Signup and view all the answers

Patients must ensure they aren't ______ before starting certain medications.

<p>pregnant</p> Signup and view all the answers

Triptan drugs, like ______, are used to treat migraines.

<p>sumatriptan</p> Signup and view all the answers

______ is an anticholinergic medication used for Parkinson's disease.

<p>Benztropine</p> Signup and view all the answers

Carbidopa-levodopa is used to increase ______ levels in Parkinson's patients.

<p>dopamine</p> Signup and view all the answers

The Transdermal ______ patch is used for chronic pain management.

<p>Fentanyl</p> Signup and view all the answers

Patients receiving Phenytoin should be aware of side effects like ______ hyperplasia.

<p>gingival</p> Signup and view all the answers

Riluzole is a medication that slows down the progression of ______.

<p>ALS</p> Signup and view all the answers

Malignant Hyperthermia is triggered by inhaled ______.

<p>anesthetics</p> Signup and view all the answers

Anticonvulsants may cause ______ and fatigue as side effects.

<p>drowsiness</p> Signup and view all the answers

Patients on Carbamazepine may experience an increased risk of ______.

<p>infection</p> Signup and view all the answers

Scopolamine is an ______ agent that prevents nausea and vomiting from motion sickness.

<p>anticholinergic</p> Signup and view all the answers

Benzodiazepines like midazolam are great for ______ sedation.

<p>conscious</p> Signup and view all the answers

St. John's wort is known to interact with most other antidepressants and may cause ______ syndrome.

<p>serotonin</p> Signup and view all the answers

Tamoxifen is an estrogen ______ that prevents breast cancer recurrence.

<p>modulator</p> Signup and view all the answers

Enoxaparin should not have its injection site ______, as it may cause bruising.

<p>rubbed</p> Signup and view all the answers

Filgrastim is used to stimulate the ______ count in patients undergoing chemotherapy.

<p>neutrophil</p> Signup and view all the answers

Cisplatin is a cancer drug that can cause major ______ issues.

<p>renal</p> Signup and view all the answers

Flashcards

Digoxin Toxicity

Digoxin, used for heart conditions, can be harmful if levels are too high. Symptoms include fast/irregular heartbeat, dizziness, and stomach problems.

Kawasaki Disease Treatment

Treat with IV immunoglobulin and aspirin to prevent coronary artery damage.

Adenosine for SVT

Adenosine is the drug of choice to treat rapid heartbeats (SVT) over 150 bpm. Given quickly near the heart, and watch the EKG.

Amiodarone Side Effects

Amiodarone, used to treat erratic heartbeats, has severe side effects like lung and thyroid problems, neuropathy and eye issues, makes your skin gray.

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Fall Risk Medications

Many blood pressure, mental health, pain, and other medications can increase the likelihood of falls.

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Thrombolytic Agents Contraindications

Drugs that break up blood clots (like tPA) aren't given to people with recent bleeding, trauma, uncontrolled high blood pressure, etc.

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Thrombin Inhibitors (dabigatran)

These drugs help prevent blood clots in stroke patients with irregular heartbeats (A-fib) by preventing thrombin from acting, but increase bleeding risk.

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Kidney Damage Symptoms

Report signs of kidney damage (like muscle aches, weakness, and dark urine) when taking certain medications immediately.

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Factor Xa Inhibitors

Oral anticoagulants like apixaban, rivaroxaban, and dabigatran that prevent blood clots.

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Potassium Sparing Diuretics

Diuretics like spironolactone that help retain potassium, often used with other diuretics.

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Loop Diuretics (furosemide, etc.)

Powerful diuretics used for heart failure, but watch for potassium loss.

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Thiazide Diuretics

Diuretics causing potassium and sodium loss, hyperuricemia, and hyperglycemia.

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Milrinone

Drug increasing heart muscle strength and blood vessel widening, for worsening heart failure.

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Prednisone & Hyperglycemia

Prednisone can cause high blood sugar, monitor blood glucose levels.

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HTN & OTC Cold Meds

Clients with high blood pressure should avoid over-the-counter cold medicines due to vasoconstriction.

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Sodium Replacement & ACE/ARBs

Avoid sodium replacements if taking ACE inhibitors or ARBs due to high potassium content.

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Desmopressin & DI

Synthetic anti-diuretic hormone (ADH) decreasing urine output and raising urine concentration to treat diabetes insipidus.

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Sulfonylureas & Hypoglycemia

Diabetes medication (glyburide, glipizide, glimepiride) that might cause low blood sugar and weight gain.

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Birth Control (BC)

Methods used to prevent pregnancy.

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Triptan drugs

Medications that treat migraines by constricting blood vessels in the head.

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Benztropine

An anticholinergic medication used for Parkinson's disease; watch for glaucoma and urinary retention.

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Carbidopa-levodopa

Increases dopamine levels; treats Parkinson's symptoms (tremor, rigidity, bradykinesia).

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Transdermal Fentanyl patch

Patches containing fentanyl used to manage moderate to severe chronic pain; takes 17 hours to kick in.

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tPA

Drug used to treat stroke symptoms, must be administered within 3-4.5 hours from onset.

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Anticonvulsants

Drugs that depress the central nervous system, use with caution due to drowsiness and potential for serious skin reactions.

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Malignant Hyperthermia

Inherited condition causing muscle rigidity, high O2 demand, and dangerously high fever. Triggered by inhaled anesthetics.

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Riluzole

Medication to slow ALS progression; has a limited effect on lifespan. ALS is a rapidly progressing, terminal disease.

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Phenytoin (anticonvulsant)

Anticonvulsant with a narrow therapeutic range. Watch for nystagmus, imbalance, and slurred speech

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Insulin Administration

Regular insulin is the only insulin for intravenous (IV) administration; others are subcutaneous (subQ).

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Insulin Mixing

Glargine insulin should never be mixed with other insulins in a syringe; only Regular (R) and NPH insulins can be mixed.

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Hypoglycemia Prevention

When administering insulin, monitor potassium levels to prevent worsening hypokalemia.

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Levothyroxine Considerations

Levothyroxine, a hypothyroidism treatment, must be taken on an empty stomach in the morning and not with antacids, calcium, or iron.

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Levothyroxine Monitoring

Levothyroxine treatment requires ongoing monitoring of TSH levels; adjustment may be needed to maintain optimal levels.

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Beers Criteria

A list of medications potentially inappropriate for older adults due to increased risk of adverse effects.

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Thiazolidinediones

Thiazolidinediones (TZDs) such as rosiglitazone and pioglitazone treat type 2 diabetes but may worsen heart rate by causing fluid retention.

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Metformin Action

Metformin is an oral antidiabetic that increases insulin receptor sensitivity and reduces glucose production by the liver.

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PPI Use

Proton pump inhibitors (PPIs) reduce gastric acid, helping conditions like peptic ulcers and GERD, but increase the risk of C.Diff.

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Sulfasalazine Risks

Sulfasalazine, used for inflammatory bowel disease (IBD), contains sulfapyridine and aspirin. It can cause dehydration and potential kidney injury.

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Scopolamine for Motion Sickness

Anticholinergic medication preventing nausea and vomiting from motion sickness. Applied as a patch.

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Benzodiazepines (Midazolam) Use

Used for conscious sedation, but carries risk of respiratory arrest.

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Iron Supplement Safety

Ferrous Sulfate treats iron deficiency, but shouldn't be taken with calcium or antacids. Vitamin C increases absorption

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Brachytherapy Precautions

Radiation treatment requiring lead shielding, time restrictions, and visitor distancing.

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Tumor Lysis Syndrome

Cancer treatment complication causing electrolyte imbalances (hypocalcemia, hyperuricemia, hyperkalemia, hyperphosphatemia).

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TNF Inhibitors and TB

Drugs reducing RA inflammation, but increasing risk of reactivating latent TB.

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Cisplatin and Renal Issues

Cancer treatment causing significant kidney problems; monitor kidney function closely.

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Study Notes

Pharmacology

  • Analgesics:
    • Morphine Sulfate: Rapid tolerance development, nausea is rare.
    • NSAIDS (ibuprofen, naproxen, Ketorolac, indomethacin, aspirin, meloxicam): Potential cardiovascular side effects (MI, stroke), decreased BP medication effectiveness, peptic ulcers, chronic kidney disease. Contraindicated in patients with hypertension or heart failure. Take with food. Do not give to those with injured kidneys.
    • Hydromorphone: Duration of action 3-4 hours
    • Naloxone: Duration of action 40 minutes. Used for opioid overdose, longer duration than the opioid, re-evaluate in an hour. Post-surgery use should not necessitate a rapid response, and unnecessary or rapid dosage is not indicated.
    • Opioids (morphine, fentanyl, hydrocodone): Constipation is a common side effect, cause pruritus, flushing, hypotension. Increased risk of respiratory depression with other sedative medications, smoking history, obesity, opioid naivety, and age over 65 years. Give slowly over 2-3 minutes. Reassess patient 15–30 minutes after administration.
    • Capsaicin (topical): Useful for osteoarthritis or neuralgia; wait 30 minutes before washing hands.

Cardiovascular

  • ACE Inhibitors (-pril):
    • Lower blood pressure and heart failure.
    • Side effects: Dry cough, angioedema (common in Black people), hyperkalemia.
    • Contraindications: Pregnancy, kidney issues.

Other Drugs

  • Alpha Agonists (clonidine, methyldopa):
    • Anti-hypertension medication.
    • Do not stop abruptly, severe rebound hypertension can occur. 2-4 days taper is necessary.
  • Beta Blockers (-lol):
    • Reduce blood pressure and heart rate.
    • Contraindicated for patients with acute decompensated heart failure, asthma or respiratory issues.
  • CCB (dipine and diltiazem, verapamil):
    • Reduce blood pressure and heart rate, used for chronic stable angina; effective for Atrial Fibrillation.
    • Side effects: Orthostatic hypotension, dizziness, headache, edema, constipation. Avoid grapefruit juice.
  • ARBs (-sartan):
    • Treat hypertension.
    • Do not take while pregnant.
    • Causes hyperkalemia.
  • Anticoagulants (heparin, fondaparinux):
    • Fondaparinux is used to prevent DVT, does not dissolve clots, used for more than 6 hours after surgery.
    • No anticoagulant during epidural catheter placement.
  • t-PA:
    • Dissolves clots in emergencies.
  • Warfarin:
    • Often used with heparin initially.
  • Antiplatelets (clopidogrel, aspirin):
    • Prevent platelet aggregation, increased bleeding risk. Monitor for signs of bleeding and decrease in platelet counts.
  • Nitrates (isosorbide mononitrate, nitroglycerin):
    • Increases cardiac blood flow, relieves angina. Frequent use can result in severe low blood pressure.
  • Statins (e.g., atorvastatin, simvastatin):
    • Lower cholesterol.
    • Increased risk of rhabdomyolysis (muscle breakdown causing kidney damage). Avoid grapefruit juice.
  • Adenocine:
    • Used for Supraventricular Tachycardia (SVT). Can cause brief asystole (a pause in heartbeat), so EKG monitoring is necessary.
  • Digoxin:
    • Treats heart failure and certain types of abnormal heart rhythms (arrhythmias). Toxicity is a concern, and serum levels need to be closely monitored.
  • Amiodarone:
    • Antiarrhythmic medication. Extreme side effects such as pulmonary toxicity and thyroid issues.
  • Thrombolytics (tPA, reteplase, alteplase):
    • Used for dissolving blood clots. High risk for bleeding.

Endocrine

  • Desmopressin:
    • Synthetic hormone, for diabetes insipidus.
  • Sulfonylureas (glyburide, glipizide, glimepiride):
    • Used for diabetes mellitus; causes hypoglycemia and weight gain.
  • Radioactive Iodine Therapy:
    • For hyperthyroidism; not for pregnant women, children.
  • Glucocorticoid replacement (prednisone, hydrocortisone):
    • Treats Addison’s disease. Report symptoms of infection. Increased risk of hyperglycemia (increased blood sugar), and report any signs of increased thirst, hunger, and urination.
  • Isoniazid:
    • Anti-TB drug, cause hepatotoxcicity and peripheral neuropathy.
  • Metformin:
    • Oral antidiabetic. Does not pose significant risk of hypoglycemia if taken with food.
  • PPI (-prazoles):
    • Suppress gastric acid production, primarily for peptic ulcer disease and GERD.
  • Sulfasalazine:
    • Treat IBD and is combined with aspirin. May damage kidney and can cause dehydration.
  • Thiazolidinediones (rosiglitazone, pioglitazone):
    • Oral antidiabetic. Monitor for any change in heart rate, rhythm, and blood pressure.
  • Metformin: Used to treat type 2 diabetes, does not cause hypoglycemia if taken with food.

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