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Questions and Answers
In which environment are acidic drugs more likely to be non-ionized?
In which environment are acidic drugs more likely to be non-ionized?
- Basic environment
- Neutral environment
- Alkaline environment
- Acidic environment (correct)
What is the predominant form of drug molecules when pH is greater than pKa?
What is the predominant form of drug molecules when pH is greater than pKa?
- Non-protonated forms (correct)
- Partially ionized forms
- Neutral forms
- Protonated forms
In which environment are basic drugs more likely to be non-ionized?
In which environment are basic drugs more likely to be non-ionized?
- Alkaline environment
- Basic environment (correct)
- Neutral environment
- Acidic environment
What does the equation pH - pKa = log [HA] represent?
What does the equation pH - pKa = log [HA] represent?
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Why are non-ionized forms of drugs generally more lipophilic?
Why are non-ionized forms of drugs generally more lipophilic?
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What happens to acid drugs in an alkaline environment?
What happens to acid drugs in an alkaline environment?
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Why do basic drugs tend to be non-ionized in the small intestine?
Why do basic drugs tend to be non-ionized in the small intestine?
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What form do basic drugs predominantly take in an acidic environment?
What form do basic drugs predominantly take in an acidic environment?
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What is the effect on drug absorption when the pH is less than pKa for a basic drug?
What is the effect on drug absorption when the pH is less than pKa for a basic drug?
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Why do non-ionized forms of drugs have faster absorption through cell membranes?
Why do non-ionized forms of drugs have faster absorption through cell membranes?
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