Pharmacology Founders and Curriculum Overview

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In which environment are acidic drugs more likely to be non-ionized?

Basic environment

Neutral environment

Alkaline environment

Acidic environment (correct)

What is the predominant form of drug molecules when pH is greater than pKa?

Non-protonated forms (correct)

Partially ionized forms

Neutral forms

Protonated forms

In which environment are basic drugs more likely to be non-ionized?

Alkaline environment

Basic environment (correct)

Neutral environment

Acidic environment

What does the equation pH - pKa = log [HA] represent?

Relationship between pH and the concentration of non-ionized acid Signup and view all the answers

Why are non-ionized forms of drugs generally more lipophilic?

They can penetrate cell membranes more easily Signup and view all the answers

What happens to acid drugs in an alkaline environment?

They become more ionized Signup and view all the answers

Why do basic drugs tend to be non-ionized in the small intestine?

To facilitate faster absorption through cell membranes Signup and view all the answers

What form do basic drugs predominantly take in an acidic environment?

Ionized form Signup and view all the answers

What is the effect on drug absorption when the pH is less than pKa for a basic drug?

Increased ionized form Signup and view all the answers

Why do non-ionized forms of drugs have faster absorption through cell membranes?

They can penetrate cell membranes more easily Signup and view all the answers

Pharmacology Founders and Curriculum Overview

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Questions and Answers

In which environment are acidic drugs more likely to be non-ionized?

What is the predominant form of drug molecules when pH is greater than pKa?

In which environment are basic drugs more likely to be non-ionized?

What does the equation pH - pKa = log [HA] represent?

Why are non-ionized forms of drugs generally more lipophilic?

What happens to acid drugs in an alkaline environment?

Why do basic drugs tend to be non-ionized in the small intestine?

What form do basic drugs predominantly take in an acidic environment?

What is the effect on drug absorption when the pH is less than pKa for a basic drug?

Why do non-ionized forms of drugs have faster absorption through cell membranes?

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