Pharmacology
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Questions and Answers

What is the primary mechanism of action of antidiarrheal medications?

  • Slow down peristalsis (correct)
  • Increase fluid and electrolyte excretion
  • Speed up peristalsis
  • Increase gut motility
  • What is a common side effect of diphenoxylate with atropine (Lomotil)?

  • Abdominal pain
  • Dizziness and drowsiness (correct)
  • Headache
  • Diarrhea
  • Which of the following patients should not be given antidiarrheal medications?

  • Patients with constipation (correct)
  • Patients with severe dehydration
  • Patients with electrolyte imbalance
  • Patients with mild dehydration
  • What is a potential complication of Camphorated opium tincture (paregoric)?

    <p>Pseudomembranous colitis</p> Signup and view all the answers

    What is the primary use of antidiarrheal medications?

    <p>For moderate to severe diarrhea</p> Signup and view all the answers

    What is an important nursing consideration when administering antidiarrheal medications?

    <p>Assess fluid and electrolyte status</p> Signup and view all the answers

    What is a potential effect of codeine?

    <p>All of the above</p> Signup and view all the answers

    What is the primary focus of pharmacodynamics?

    <p>The examination of the effects of foreign chemicals on living systems</p> Signup and view all the answers

    What is the term for the process by which a drug is converted into a more soluble form for excretion?

    <p>Biotransformation</p> Signup and view all the answers

    Which of the following is NOT a nursing contraindication for anxiolytic and hypnotic agents?

    <p>Mixing IV drugs with other drugs to avoid potential drug-drug interactions</p> Signup and view all the answers

    What is the primary reason for giving IV medications slowly for anxiolytic and hypnotic agents?

    <p>To prevent cardiac problems</p> Signup and view all the answers

    Which of the following is a type of drug used to treat glaucoma?

    <p>Beta-adrenergic blockers</p> Signup and view all the answers

    What is the term for the process by which a drug is distributed to the active site in the body?

    <p>Distribution</p> Signup and view all the answers

    What is the term for the dynamic equilibrium involving several processes that determines the actual concentration of a drug in the body?

    <p>Pharmacokinetics</p> Signup and view all the answers

    What is the primary diagnosis method for Irritable Bowel Syndrome (IBS)?

    <p>Diagnosis of exclusion</p> Signup and view all the answers

    What is the primary goal of lifestyle changes in managing IBS?

    <p>To manage stress and anxiety</p> Signup and view all the answers

    What is the primary mechanism of action of anticholinergic medications in treating IBS?

    <p>Reducing bowel spasms</p> Signup and view all the answers

    What is the typical pattern of bowel habits in IBS?

    <p>Alternating between diarrhea and constipation</p> Signup and view all the answers

    What is the primary indication for the use of Tegaserod in IBS?

    <p>Constipation-predominant IBS</p> Signup and view all the answers

    What is the term for the excess gas and bloating characteristic of IBS?

    <p>Excessive flatulence</p> Signup and view all the answers

    What is the primary difference between IBS and inflammatory bowel disease (IBD)?

    <p>IBS is a functional disorder, while IBD is a structural disorder</p> Signup and view all the answers

    What is the purpose of bulk laxatives, such as Psyllium, in managing IBS?

    <p>To add bulk to stool and promote regular bowel movements</p> Signup and view all the answers

    What is the primary mechanism of action of sulfonamides?

    <p>Inhibiting bacterial synthesis of folic acid</p> Signup and view all the answers

    Which of the following bacteria is susceptible to 3rd generation cephalosporins?

    <p>Klebsiella</p> Signup and view all the answers

    What is the primary use of sulfonamides?

    <p>For treating urinary tract infections</p> Signup and view all the answers

    What is the characteristic of 4th and 5th generation cephalosporins?

    <p>Capable of entering CSF to treat CNS infections</p> Signup and view all the answers

    What is the common adverse effect of sulfonamides?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is a 5th generation cephalosporin?

    <p>Ceftaroline</p> Signup and view all the answers

    What is the characteristic of 3rd generation cephalosporins?

    <p>Effective against Klebsiella and Pseudomonas</p> Signup and view all the answers

    What is the mechanism of action of sulfonamides?

    <p>Bacteriostatic</p> Signup and view all the answers

    Why is multiple drug therapy necessary for treating tuberculosis?

    <p>To prevent bacterial resistance and increase the chances of successful therapy</p> Signup and view all the answers

    Why are nonpharmacologic techniques used concurrently with medication in treating pain?

    <p>To allow for lower doses of drugs with fewer adverse effects</p> Signup and view all the answers

    What is the primary advantage of using multiple antitubercular drugs in different combinations?

    <p>Lowering the potential for resistance and increasing the chances for successful therapy</p> Signup and view all the answers

    Why is it critical to take antitubercular medication for 6 to 12 months, and possibly as long as 24 months?

    <p>To ensure that the medication is effective against the tuberculosis bacterium</p> Signup and view all the answers

    What is the primary purpose of using antitubercular drugs such as pyrazinamide, isoniazid, and rifampin?

    <p>To treat and prevent clients who have a positive TB test</p> Signup and view all the answers

    Why is it necessary to take precautions to avoid adverse effects when using antitubercular drugs?

    <p>Because the drugs can cause adverse effects</p> Signup and view all the answers

    What is the primary reason why single drug use is not recommended for treating tuberculosis?

    <p>Because it increases the risk of bacterial resistance</p> Signup and view all the answers

    What is the primary goal of using multiple antitubercular drugs in combination?

    <p>To prevent bacterial resistance and increase the chances for successful therapy</p> Signup and view all the answers

    Study Notes

    Pharmacodynamics

    • Pharmocodynamics is the science dealing with interactions between the chemical components of living systems and foreign chemicals, including drugs, that enter those systems.
    • It examines how a drug affects living tissues within an organism.
    • The actual concentration of a drug in the body results from a dynamic equilibrium involving several processes:
      • Absorption from the site of entry
      • Distribution to the active site
      • Biotransformation (metabolism) in the liver
      • Excretion from the body

    Anxiolytics and Hypnotic Agents

    • Barbiturates include:
      • Amobarbital (Amytal Sodium)
      • Pentobarbital (Nembutal)
      • Phenobarbital (Luminal)
      • Secobarbital (Seconal)
    • Nursing contraindications:
      • Assess for baseline status before beginning therapy and for occurrence of any adverse effects
      • Do not mix IV drugs with any other drugs to avoid potential drug-drug interactions
      • Give parenteral forms only if oral forms are not feasible
      • Give IV medications slowly to avoid potential cardiac problems
      • Provide standby life-support facilities in case of severe respiratory or hypersensitivity reactions
      • Taper dose gradually to avoid precipitating seizures and withdrawal syndrome
      • Provide support measures

    Pharmacotherapy of Glaucoma

    • Selected drugs for glaucoma:
      • Prostaglandins
      • Beta-adrenergic blockers
      • Alpha2-adrenergic agonists
      • Carbonic anhydrase inhibitors
      • Cholinergic Agonists (Miotics)

    Antidiarrheals and Opioids

    • Mechanism of action: slows peristalsis, allowing for more fluid and electrolyte absorption
    • Primary use: for moderate to severe diarrhea
    • Drugs:
      • Diphenoxylate with atropine (Lomotil)
      • Codeine
      • Loperamide (Imodium)
      • Difenoxin +atropine (Motofen)
      • Camphorated opium tincture (Paregoric)
      • Bismuth salts
      • Lactobacillus acidophilus
      • Octreotide (Sandostatin)
    • Side effects and nursing considerations:
      • Assess fluid and electrolyte status
      • Assess for blood in stool
      • Do not use if constipation should be avoided
      • Assess patient's ability to get out of bed safely
      • Antidiarrheals contraindicated in some patients, such as those with severe dehydration, electrolyte imbalance, liver, and renal disorders, and glaucoma

    Irritable Bowel Syndrome (IBS)

    • Also known as spastic colon or mucous colitis
    • Common disorder of the lower gastrointestinal tract
    • Symptoms:
      • Abdominal pain, bloating, excessive gas, and colicky cramping
      • Diarrhea alternating with constipation
      • Mucus in stool
    • Causes:
      • Functional bowel disorder
    • Treatment:
      • Supportive, symptomatic treatment
      • Lifestyle changes, including dietary changes and relaxation therapy
      • Altered bowel habits
      • Bulk laxatives, such as psyllium
      • Anticholinergic medications, such as dicyclomine (Bentyl)
      • Tegaserod

    Cephalosporins

    • Mechanism of action: inhibits bacterial cell wall synthesis
    • 3rd generation:
      • Cefdinir, cefixime, cefotaxime, ceftazidime, ceftriaxone
      • Longer duration of action, resistant to beta-lactamase
      • Drug of choice for klebsiella, pseudomonas, Neisseria, salmonella, proteus, and H. influenza
    • 4th and 5th generation:
      • Cefepime, ceftaroline
      • Effective against organisms that develop resistance to earlier cephalosporins
      • 4th generation: capable of entering CSF to treat CNS infections
      • 5th generation: effective against MRSA

    Sulfonamides

    • Mechanism of action: suppresses bacterial growth by inhibiting bacterial synthesis of folic acid (bacteriostatic)
    • Wide spectrum against both gram-negative and gram-positive bacteria
    • Also known as folic acid inhibitors
    • Primary use: for urinary tract infections, Pneumocystis carinii pneumonia, and shigella infections of the small bowel
    • Drugs:
      • Trimethoprim-sulfamethoxazole (Bactrim, Septra)
      • Sulfadiazine
    • Side effects and nursing considerations:
      • Monitor for hypersensitivity to the drug
      • Monitor adverse effects
      • Monitor for agranulocytosis

    Antitubercular Drugs

    • Mechanism of action: inhibits bacterial growth and replication
    • Multiple drug therapy is necessary because the Mycobacteria grow slowly, and resistance is common
    • Using multiple drugs in different combinations during the long treatment period lowers the potential for resistance and increases the chances for successful therapy
    • Precautions to avoid adverse effects are required, and the drugs will be required for a longer period than 1 month

    Pain Management

    • Nonpharmacologic techniques, such as relaxation techniques and guided imagery, can be used as an adjunct to medication for pain management
    • Rationale: may allow for lower doses of drugs with fewer adverse effects

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    This quiz covers the concept of pharmacodynamics, which deals with the interactions between drugs and living systems, including how drugs affect the body and living tissues.

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