Pharmacology: Dual Antiplatelet Therapy and ADP Antagonists

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Which of the following oral anticoagulants is considered safe for use during pregnancy?

Apixaban (correct)

Edoxaban

Warfarin

Rivaroxaban

What is the primary mechanism of action of thrombolytics in dissolving a thrombus?

Activation of the fibrinolytic system (correct)

Inhibition of factor Xa

Blockade of platelet aggregation

Inhibition of thrombin activity

Which type of thrombolytic agent is considered more fibrin-specific?

Streptokinase

Urokinase

Tenecteplase

Tissue plasminogen activator (tPA) (correct)

Which thrombolytic agent is considered less fibrin-specific?

Streptokinase Signup and view all the answers

What is the recommended dose of aspirin for inhibiting platelet aggregation in the prevention of cardiovascular events?

75-100 mg per day Signup and view all the answers

Which anticoagulant drug is known to have a narrow therapeutic window and requires frequent monitoring of the international normalized ratio (INR)?

Warfarin Signup and view all the answers

Which of the following is the most common mechanism of action for oral anticoagulants used during pregnancy?

Inhibition of vitamin K-dependent clotting factors Signup and view all the answers

What is the primary mechanism of action for fibrin-specific thrombolytics like alteplase (tPA)?

Activation of plasminogen to plasmin Signup and view all the answers

Which of the following is the mechanism of action for fibrin-non-specific thrombolytics like streptokinase?

Activation of plasminogen to plasmin Signup and view all the answers

What is the typical loading dose for clopidogrel in the setting of an acute coronary syndrome?

4 tablets Signup and view all the answers

How long is dual antiplatelet therapy (DAPT) typically recommended after an acute coronary syndrome?

6-12 months Signup and view all the answers

What is the typical duration of infusion for glycoprotein IIb/IIIa inhibitors in the setting of a percutaneous coronary intervention?

During the procedure and until hospital discharge Signup and view all the answers

Which anticoagulant is favorably given outside the hospital setting due to its longer duration of action and less tendency to induce immune reactions?

Low Molecular Weight Heparin (LMWH) Signup and view all the answers

Which type of anticoagulant is specifically recommended in treating thrombosis caused by immune reactions to heparin?

Direct Thrombin Inhibitors Signup and view all the answers

How do Factor X Inhibitors suppress thrombin formation?

Directly through binding Signup and view all the answers

Which group of anticoagulants includes both Oral Direct Thrombin Inhibitors and Factor X Inhibitors?

NOACs Signup and view all the answers

Which anticoagulant is known to be less hazardous than warfarin according to the text?

Unfractionated heparin Signup and view all the answers

In what way do Direct Thrombin Inhibitors act on thrombin, whether present as free or fibrin bound?

By binding directly to inhibit thrombin Signup and view all the answers