Pharmacology: Dual Antiplatelet Therapy and ADP Antagonists

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Questions and Answers

Which of the following oral anticoagulants is considered safe for use during pregnancy?

  • Apixaban (correct)
  • Edoxaban
  • Warfarin
  • Rivaroxaban

What is the primary mechanism of action of thrombolytics in dissolving a thrombus?

  • Activation of the fibrinolytic system (correct)
  • Inhibition of factor Xa
  • Blockade of platelet aggregation
  • Inhibition of thrombin activity

Which type of thrombolytic agent is considered more fibrin-specific?

  • Streptokinase
  • Urokinase
  • Tenecteplase
  • Tissue plasminogen activator (tPA) (correct)

Which thrombolytic agent is considered less fibrin-specific?

<p>Streptokinase (D)</p> Signup and view all the answers

What is the recommended dose of aspirin for inhibiting platelet aggregation in the prevention of cardiovascular events?

<p>75-100 mg per day (A)</p> Signup and view all the answers

Which anticoagulant drug is known to have a narrow therapeutic window and requires frequent monitoring of the international normalized ratio (INR)?

<p>Warfarin (D)</p> Signup and view all the answers

Which of the following is the most common mechanism of action for oral anticoagulants used during pregnancy?

<p>Inhibition of vitamin K-dependent clotting factors (C)</p> Signup and view all the answers

What is the primary mechanism of action for fibrin-specific thrombolytics like alteplase (tPA)?

<p>Activation of plasminogen to plasmin (C)</p> Signup and view all the answers

Which of the following is the mechanism of action for fibrin-non-specific thrombolytics like streptokinase?

<p>Activation of plasminogen to plasmin (B)</p> Signup and view all the answers

What is the typical loading dose for clopidogrel in the setting of an acute coronary syndrome?

<p>4 tablets (D)</p> Signup and view all the answers

How long is dual antiplatelet therapy (DAPT) typically recommended after an acute coronary syndrome?

<p>6-12 months (A)</p> Signup and view all the answers

What is the typical duration of infusion for glycoprotein IIb/IIIa inhibitors in the setting of a percutaneous coronary intervention?

<p>During the procedure and until hospital discharge (A)</p> Signup and view all the answers

Which anticoagulant is favorably given outside the hospital setting due to its longer duration of action and less tendency to induce immune reactions?

<p>Low Molecular Weight Heparin (LMWH) (D)</p> Signup and view all the answers

Which type of anticoagulant is specifically recommended in treating thrombosis caused by immune reactions to heparin?

<p>Direct Thrombin Inhibitors (D)</p> Signup and view all the answers

How do Factor X Inhibitors suppress thrombin formation?

<p>Directly through binding (B)</p> Signup and view all the answers

Which group of anticoagulants includes both Oral Direct Thrombin Inhibitors and Factor X Inhibitors?

<p>NOACs (B)</p> Signup and view all the answers

Which anticoagulant is known to be less hazardous than warfarin according to the text?

<p>Unfractionated heparin (D)</p> Signup and view all the answers

In what way do Direct Thrombin Inhibitors act on thrombin, whether present as free or fibrin bound?

<p>By binding directly to inhibit thrombin (D)</p> Signup and view all the answers

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