8 Questions
What is the primary mechanism of action of aspirin in Dual Antiplatelet Therapy (DAPT)?
Inhibiting cyclooxygenase-1 (COX-1)
In Dual Antiplatelet Therapy (DAPT), which of the following medications is associated with the risk of Thrombotic Thrombocytopenic Purpura (TTP)?
Clopidogrel
What is the recommended duration of Dual Antiplatelet Therapy (DAPT) for patients with Acute Coronary Syndrome (ACS)?
12 months
Which of the following is a common side effect of ticagrelor in Dual Antiplatelet Therapy (DAPT)?
Dyspnea
What is the primary goal of Dual Antiplatelet Therapy (DAPT)?
To prevent platelet activation and aggregation
In Dual Antiplatelet Therapy (DAPT), which of the following medications is used in combination with aspirin?
P2Y12 inhibitor
What is the primary indication for Dual Antiplatelet Therapy (DAPT)?
Acute Coronary Syndrome (ACS)
What is the purpose of regular platelet function testing in Dual Antiplatelet Therapy (DAPT)?
To assess the response to therapy
Study Notes
Definition and Purpose
Dual Antiplatelet Therapy (DAPT) is a treatment approach that combines two antiplatelet medications to prevent platelet activation and aggregation, reducing the risk of thrombotic events.
Mechanism of Action
- Aspirin inhibits cyclooxygenase-1 (COX-1), reducing thromboxane A2 production and platelet activation.
- P2Y12 inhibitors (e.g., clopidogrel, prasugrel, ticagrelor) block the P2Y12 receptor, preventing ADP-mediated platelet activation.
Indications
- Acute Coronary Syndrome (ACS):
- ST-Elevation Myocardial Infarction (STEMI)
- Non-ST-Elevation Myocardial Infarction (NSTEMI)
- Unstable Angina
- Percutaneous Coronary Intervention (PCI):
- Bare Metal Stents (BMS)
- Drug-Eluting Stents (DES)
Regimens
- Aspirin + P2Y12 inhibitor:
- Aspirin 81-325 mg daily
- Clopidogrel 75 mg daily
- Prasugrel 10 mg daily
- Ticagrelor 90 mg twice daily
Duration of Therapy
- ACS: 12 months
- PCI: 1-12 months, depending on the type of stent and patient characteristics
Risks and Side Effects
- Bleeding risk: increased with DAPT
- Gastrointestinal bleeding: aspirin
- Thrombotic Thrombocytopenic Purpura (TTP): clopidogrel
- Dyspnea: ticagrelor
Monitoring and Adjustments
- Regular platelet function testing to assess response to therapy
- Adjust dosages or switch medications based on patient response and risk factors
Dual Antiplatelet Therapy (DAPT)
- Combines two antiplatelet medications to prevent platelet activation and aggregation, reducing the risk of thrombotic events.
Mechanism of Action
- Aspirin inhibits cyclooxygenase-1 (COX-1), reducing thromboxane A2 production and platelet activation.
- P2Y12 inhibitors block the P2Y12 receptor, preventing ADP-mediated platelet activation.
Indications
- Acute Coronary Syndrome (ACS):
- ST-Elevation Myocardial Infarction (STEMI)
- Non-ST-Elevation Myocardial Infarction (NSTEMI)
- Unstable Angina
- Percutaneous Coronary Intervention (PCI):
- Bare Metal Stents (BMS)
- Drug-Eluting Stents (DES)
Regimens
- Aspirin + P2Y12 inhibitor:
- Aspirin 81-325 mg daily
- Clopidogrel 75 mg daily
- Prasugrel 10 mg daily
- Ticagrelor 90 mg twice daily
Duration of Therapy
- ACS: 12 months
- PCI: 1-12 months, depending on the type of stent and patient characteristics
Risks and Side Effects
- Bleeding risk: increased with DAPT
- Gastrointestinal bleeding: aspirin
- Thrombotic Thrombocytopenic Purpura (TTP): clopidogrel
- Dyspnea: ticagrelor
Monitoring and Adjustments
- Regular platelet function testing to assess response to therapy
- Adjust dosages or switch medications based on patient response and risk factors
Learn about Dual Antiplatelet Therapy, a treatment approach combining two antiplatelet medications to prevent platelet activation and aggregation, reducing the risk of thrombotic events. Understand its mechanism of action and indications.
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