Dual Antiplatelet Therapy (DAPT) in Cardiology
6 Questions
1 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary mechanism of action of aspirin in dual antiplatelet therapy?

  • Stimulating platelet production, increasing platelet count
  • Inhibiting thromboxane A2 production, preventing platelet activation (correct)
  • Blocking P2Y12 receptor, preventing ADP-mediated platelet activation
  • Enhancing platelet aggregation, promoting thrombosis
  • In which of the following situations is dual antiplatelet therapy typically contraindicated?

  • Pregnancy or breastfeeding (correct)
  • Acute coronary syndrome
  • Percutaneous coronary intervention
  • Cardiac surgery
  • What is the primary benefit of dual antiplatelet therapy in patients with acute coronary syndrome?

  • Reduced risk of bleeding
  • Enhanced platelet aggregation
  • Increased platelet production
  • Improved outcomes in patients with ACS (correct)
  • What is the typical duration of dual antiplatelet therapy after acute coronary syndrome or percutaneous coronary intervention?

    <p>12 months</p> Signup and view all the answers

    What is the primary risk of dual antiplatelet therapy?

    <p>Increased risk of bleeding</p> Signup and view all the answers

    What is the purpose of regular platelet function tests in dual antiplatelet therapy?

    <p>To ensure adequate platelet inhibition</p> Signup and view all the answers

    Study Notes

    Definition and Purpose

    Dual antiplatelet therapy (DAPT) is a combination of two antiplatelet medications, typically aspirin and a P2Y12 inhibitor, used to prevent platelet activation and thrombosis.

    Mechanism of Action

    • Aspirin: inhibits thromboxane A2 production, preventing platelet activation
    • P2Y12 inhibitor (e.g., clopidogrel, prasugrel, ticagrelor): blocks P2Y12 receptor, preventing ADP-mediated platelet activation

    Indications

    • Acute coronary syndrome (ACS)
    • Percutaneous coronary intervention (PCI)
    • Coronary artery stenting
    • Cardiac surgery

    Benefits

    • Reduced risk of cardiovascular death, myocardial infarction, and stroke
    • Improved outcomes in patients with ACS and PCI

    Risks and Side Effects

    • Increased risk of bleeding
    • Gastrointestinal bleeding and ulceration
    • Thrombocytopenia

    Duration of Therapy

    • Typically 12 months after ACS or PCI
    • May be extended or shortened based on individual patient needs and risk factors

    Monitoring and Titration

    • Regular platelet function tests to ensure adequate platelet inhibition
    • Adjust medication dosages as needed to achieve optimal platelet inhibition

    Contraindications

    • Active bleeding or high risk of bleeding
    • Pregnancy or breastfeeding
    • Allergy or intolerance to aspirin or P2Y12 inhibitors

    Definition and Purpose

    • Dual antiplatelet therapy (DAPT) combines two antiplatelet medications to prevent platelet activation and thrombosis.
    • Typically consists of aspirin and a P2Y12 inhibitor.

    Mechanism of Action

    • Aspirin inhibits thromboxane A2 production, preventing platelet activation.
    • P2Y12 inhibitors (e.g., clopidogrel, prasugrel, ticagrelor) block P2Y12 receptors, preventing ADP-mediated platelet activation.

    Indications

    • Acute coronary syndrome (ACS)
    • Percutaneous coronary intervention (PCI)
    • Coronary artery stenting
    • Cardiac surgery

    Benefits

    • Reduces risk of cardiovascular death, myocardial infarction, and stroke
    • Improves outcomes in patients with ACS and PCI

    Risks and Side Effects

    • Increases risk of bleeding
    • Causes gastrointestinal bleeding and ulceration
    • May cause thrombocytopenia

    Duration of Therapy

    • Typically 12 months after ACS or PCI
    • May be extended or shortened based on individual patient needs and risk factors

    Monitoring and Titration

    • Regular platelet function tests ensure adequate platelet inhibition
    • Medication dosages are adjusted as needed to achieve optimal platelet inhibition

    Contraindications

    • Active bleeding or high risk of bleeding
    • Pregnancy or breastfeeding
    • Allergy or intolerance to aspirin or P2Y12 inhibitors

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Description

    Learn about the mechanisms and indications of dual antiplatelet therapy, a combination of aspirin and a P2Y12 inhibitor, used to prevent platelet activation and thrombosis in cardiovascular diseases.

    More Like This

    Use Quizgecko on...
    Browser
    Browser