Pharmacology: Aspirin's Medical Applications
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Questions and Answers

What is the primary mechanism of action of COX-II selective inhibitors?

  • Blocking COX-I activity more than COX-II activity
  • Inhibiting platelet aggregation
  • Increasing renal blood flow
  • Selectively blocking COX-II activity more than COX-I activity (correct)

    • What is a major advantage of COX-II selective inhibitors over NSAIDs?

  • Gastro protective effects (correct)
  • Anti-platelet activity
  • Increased renal blood flow
  • Cardio protective effects

    • Which of the following is a contraindication for diclofenac?

  • Osteoarthritis
  • Renal colic
  • Pregnancy (correct)
  • Hypertension

    • What is the dose of diclofenac for its various indications?

    <p>50mg/BD</p> Signup and view all the answers

    Which of the following is a disadvantage of COX-II selective inhibitors?

    <p>No action on platelet aggregation</p> Signup and view all the answers

    What is the effect of COX-II selective inhibitors on renal blood flow?

    <p>Decrease</p> Signup and view all the answers

    What is the key difference between selective COX-2 inhibitors and nonselective COX1/COX-2 inhibitors?

    <p>Their effect on platelet aggregation</p> Signup and view all the answers

    Why is aspirin contraindicated in children with viral infections such as influenza?

    <p>Risk of Reye's syndrome</p> Signup and view all the answers

    What is a concern when using aspirin in pregnant women near term?

    <p>All of the above</p> Signup and view all the answers

    What is the lowest dose of aspirin required for?

    <p>Antiplatelet aggregatory effects</p> Signup and view all the answers

    What is a characteristic of nonselective COX1/COX-2 inhibitors?

    <p>They inhibit platelet aggregation</p> Signup and view all the answers

    What is a potential adverse effect of using aspirin during pregnancy?

    <p>Premature closure of the ductus arteriosus</p> Signup and view all the answers

    What might be retarded by selective inhibition of thromboxane A2 synthesis by low dose aspirin therapy?

    <p>Pregnancy induced hypertension</p> Signup and view all the answers

    Which analgesic frequently causes headache as a side effect?

    <p>Indomethacin</p> Signup and view all the answers

    What is an advantage of selective COX-2 inhibitors over nonselective NSAIDs?

    <p>They are less likely to cause gastric ulcers</p> Signup and view all the answers

    What is an advantage of paracetamol over NSAIDs?

    <p>It has a lower risk of gastric ulcers</p> Signup and view all the answers

    What is a potential complication of nonselective NSAIDs?

    <p>All of the above</p> Signup and view all the answers

    What is the site of action of aspirin in inhibiting thromboxane A2 synthesis?

    <p>Platelets</p> Signup and view all the answers

    What is the primary advantage of paracetamol over NSAIDs in terms of patient demographics?

    <p>It can be safely administered to all age groups</p> Signup and view all the answers

    What is the benefit of paracetamol in pregnant or breastfeeding women?

    <p>It is not contraindicated in these populations</p> Signup and view all the answers

    What is the mechanism by which N-acetyl cysteine is beneficial in acute paracetamol poisoning?

    <p>It replenishes hepatic glutathione</p> Signup and view all the answers

    In what patient population is paracetamol considered the first choice analgesic?

    <p>Patients with osteoarthritis</p> Signup and view all the answers

    What is a unique advantage of paracetamol over NSAIDs in terms of safety?

    <p>It is not contraindicated in pregnant or breastfeeding women</p> Signup and view all the answers

    What is the role of N-acetyl cysteine in the management of paracetamol poisoning?

    <p>It is an antidote for paracetamol</p> Signup and view all the answers

    What is the typical dose of aspirin used to reduce the risk of pregnancy-related hypertension and preeclampsia?

    <p>80-100mg</p> Signup and view all the answers

    What is the main difference between aspirin and paracetamol in terms of their effects on the body?

    <p>Aspirin is an anti-inflammatory, while paracetamol is not</p> Signup and view all the answers

    What is the common consequence of taking a large dose of paracetamol, especially in small children?

    <p>Serious liver toxicity</p> Signup and view all the answers

    What is the recommended dose of paracetamol for analgesic and antipyretic effects?

    <p>500mg TID</p> Signup and view all the answers

    What is the main indication for using aspirin as an antiplatelet agent?

    <p>Post MI and post-stroke</p> Signup and view all the answers

    What is the dose of aspirin used to close the ductus arteriosus?

    <p>Not specified in the text</p> Signup and view all the answers

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