30 Questions
What is the primary mechanism of action of COX-II selective inhibitors?
Selectively blocking COX-II activity more than COX-I activity
What is a major advantage of COX-II selective inhibitors over NSAIDs?
Gastro protective effects
Which of the following is a contraindication for diclofenac?
Pregnancy
What is the dose of diclofenac for its various indications?
50mg/BD
Which of the following is a disadvantage of COX-II selective inhibitors?
No action on platelet aggregation
What is the effect of COX-II selective inhibitors on renal blood flow?
Decrease
What is the key difference between selective COX-2 inhibitors and nonselective COX1/COX-2 inhibitors?
Their effect on platelet aggregation
Why is aspirin contraindicated in children with viral infections such as influenza?
Risk of Reye's syndrome
What is a concern when using aspirin in pregnant women near term?
All of the above
What is the lowest dose of aspirin required for?
Antiplatelet aggregatory effects
What is a characteristic of nonselective COX1/COX-2 inhibitors?
They inhibit platelet aggregation
What is a potential adverse effect of using aspirin during pregnancy?
Premature closure of the ductus arteriosus
What might be retarded by selective inhibition of thromboxane A2 synthesis by low dose aspirin therapy?
Pregnancy induced hypertension
Which analgesic frequently causes headache as a side effect?
Indomethacin
What is an advantage of selective COX-2 inhibitors over nonselective NSAIDs?
They are less likely to cause gastric ulcers
What is an advantage of paracetamol over NSAIDs?
It has a lower risk of gastric ulcers
What is a potential complication of nonselective NSAIDs?
All of the above
What is the site of action of aspirin in inhibiting thromboxane A2 synthesis?
Platelets
What is the primary advantage of paracetamol over NSAIDs in terms of patient demographics?
It can be safely administered to all age groups
What is the benefit of paracetamol in pregnant or breastfeeding women?
It is not contraindicated in these populations
What is the mechanism by which N-acetyl cysteine is beneficial in acute paracetamol poisoning?
It replenishes hepatic glutathione
In what patient population is paracetamol considered the first choice analgesic?
Patients with osteoarthritis
What is a unique advantage of paracetamol over NSAIDs in terms of safety?
It is not contraindicated in pregnant or breastfeeding women
What is the role of N-acetyl cysteine in the management of paracetamol poisoning?
It is an antidote for paracetamol
What is the typical dose of aspirin used to reduce the risk of pregnancy-related hypertension and preeclampsia?
80-100mg
What is the main difference between aspirin and paracetamol in terms of their effects on the body?
Aspirin is an anti-inflammatory, while paracetamol is not
What is the common consequence of taking a large dose of paracetamol, especially in small children?
Serious liver toxicity
What is the recommended dose of paracetamol for analgesic and antipyretic effects?
500mg TID
What is the main indication for using aspirin as an antiplatelet agent?
Post MI and post-stroke
What is the dose of aspirin used to close the ductus arteriosus?
Not specified in the text
Test your knowledge of aspirin's uses in various medical conditions, including acute rheumatic fever, arthritis, and cardiovascular diseases. Learn about the recommended dosages and its effects on platelet aggregation and pregnancy-related hypertension.
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