Aspirin's Antithrombotic Effects

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What is a characteristic of NSAIDs?

Have high physical dependence and abuse liability
Are stronger analgesics than morphine
Do not produce CNS depression (correct)
Produce CNS depression

What is the mechanism of action of NSAIDs?

Prevent synthesis of prostaglandins by stimulating COX enzyme
Stimulate synthesis of prostaglandins by stimulating COX enzyme
Stimulate synthesis of prostaglandins by inhibiting COX enzyme
Prevent synthesis of prostaglandins by inhibiting COX enzyme (correct)

Which of the following is a preferential COX-2 inhibitor?

Diclofenac
Naproxen
Ibuprofen
Meloxicam (correct)

What is the main mechanism of analgesic effect of NSAIDs?

Peripheral inhibition of PG production (A) Signup and view all the answers

Which of the following NSAIDs does not inhibit prostaglandin synthesis?

Nefopam (D) Signup and view all the answers

What is the effect of NSAIDs on pain receptors?

Decrease sensitivity (C) Signup and view all the answers

Which of the following is an analgesic and antipyretic with least anti-inflammatory action?

Paracetamol (D) Signup and view all the answers

What is the effect of NSAIDs on pain threshold?

Increase (D) Signup and view all the answers

In what type of pain are NSAIDs effective?

Mild to moderate integumental pain (D) Signup and view all the answers

Which of the following is not a learning outcome of NSAIDs?

Explain the mechanism of action of antibiotics (B) Signup and view all the answers

What is the age limit for NSAIDs in children?

Below 12 years of age (B) Signup and view all the answers

What is a condition in which non-selective COX inhibitors are contraindicated?

Peptic ulcer (A) Signup and view all the answers

What is the purpose of learning outcome 7?

To choose an appropriate NSAID for a given clinical condition (C) Signup and view all the answers

What is the learning outcome related to paracetamol poisoning?

Explain the manifestations of paracetamol poisoning (A) Signup and view all the answers

What is the topic of learning outcome 10?

Topical NSAIDs and analgesic combinations used in pain management (B) Signup and view all the answers

Which of the following is a learning outcome of NSAIDs?

Explain the pharmacological actions of NSAIDs (C) Signup and view all the answers

How many learning outcomes are related to NSAIDs?

11 (A) Signup and view all the answers

Which of the following is a contraindication for non-selective COX inhibitors?

Bleeding disorders (A) Signup and view all the answers

What is the effect of NSAIDs on the hypothalamic thermostat?

Lower the thermostat's setting (A) Signup and view all the answers

What is the result of excess PG in the body?

Hyperpyrexia (C) Signup and view all the answers

What do NSAIDs inhibit in the body?

The production of PG (C) Signup and view all the answers

In what type of inflammation do NSAIDs provide relief by reversing vasodilatation and increased vascular permeability?

Acute inflammation (D) Signup and view all the answers

What is the effect of NSAIDs on granulocyte adherence to damaged vasculature?

They decrease adherence (A) Signup and view all the answers

What is the effect of NSAIDs on lysosomal membrane?

They stabilize it (B) Signup and view all the answers

What is the effect of NSAIDs on chemotaxis?

They decrease it (A) Signup and view all the answers

What is the relationship between the doses of NSAIDs for analgesic, antipyretic, and anti-inflammatory effects?

Anti-inflammatory dose is higher than analgesic and antipyretic doses (D) Signup and view all the answers

What is the effect of NSAIDs on T cell function?

They modulate it (B) Signup and view all the answers

What is the term for the kidney damage caused by chronic consumption of aspirin and other NSAIDs?

Analgesic nephropathy (A) Signup and view all the answers

Why should NSAIDs be avoided in asthmatics?

Due to increased production of leukotrienes (A) Signup and view all the answers

What is the potential complication of taking NSAIDs near term in pregnancy?

Post-partum hemorrhage (B) Signup and view all the answers

What is the effect of long-term use of aspirin on prothrombin levels?

Decreases prothrombin levels (D) Signup and view all the answers

Why is aspirin contraindicated in hemophilia?

Due to increased risk of bleeding (D) Signup and view all the answers

What is the effect of aspirin on uric acid excretion?

Decreases uric acid excretion (C) Signup and view all the answers

What is the condition caused by the use of aspirin in children with viral infection?

Reye's syndrome (A) Signup and view all the answers

Why should aspirin be stopped one week before surgery?

To reduce the risk of bleeding (C) Signup and view all the answers

What is the effect of aspirin on platelet TXA2 synthesis when taken in low doses?

It irreversibly inhibits platelet TXA2 synthesis (D) Signup and view all the answers

Why does aspirin lose its antiplatelet effect at high doses?

Because it inhibits both PGI2 and TXA2 synthesis (D) Signup and view all the answers

Why is aspirin not withdrawn 2 days before elective surgery?

Because its effect on platelets lasts for 8-10 days (C) Signup and view all the answers

How are NSAIDs absorbed from the GI tract?

Through passive diffusion (D) Signup and view all the answers

What is the peak time of NSAIDs after administration?

Within 1-4 hours (A) Signup and view all the answers

What percentage of NSAIDs are bound to plasma proteins?

80-90% (D) Signup and view all the answers

What is the effect of aspirin on the plasma concentrations of other drugs?

It increases the plasma concentrations of other drugs (B) Signup and view all the answers

What is the kinetic order of aspirin at higher doses?

Zero order (B) Signup and view all the answers

What is the main site of inactivation of NSAIDs?

Hepatic ER and mitochondria (C) Signup and view all the answers

NSAIDs characteristic

Do not cause central nervous system depression.

NSAIDs MOA

Prevent prostaglandin synthesis by inhibiting COX enzyme.