Pharmacology and Pharmacokinetics
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Questions and Answers

What is pharmacology primarily concerned with?

  • The genetic engineering of drugs.
  • The synthesis of new chemical entities for medical use.
  • The study of chemical interactions of substances with living systems. (correct)
  • The mechanical properties of drugs.

What are pharmacodynamic processes?

  • The actions of the body on the drug.
  • The process of drug discovery and development.
  • The actions of the drug on the body. (correct)
  • The rate of drug excretion from the body.

Which of the following describes pharmacokinetic processes?

  • The actions of the body on the drug. (correct)
  • The effects of a drug on specific organs.
  • The psychological effects of drug use.
  • The study of drug synthesis.

What is the first step in pharmacokinetics?

<p>Absorption (C)</p> Signup and view all the answers

In pharmacokinetics, what follows absorption?

<p>Distribution (D)</p> Signup and view all the answers

Where does the biotransformation of drugs by metabolism primarily occur?

<p>Liver (B)</p> Signup and view all the answers

What is a key factor in determining the route of drug administration?

<p>The need for rapid onset of the drug (C)</p> Signup and view all the answers

Flashcards

Pharmacology

The study of substances interacting with living systems through chemical processes.

Pharmacodynamics

Actions of the drug on the body affecting its response.

Pharmacokinetics

Actions of the body on the drug, including absorption, distribution, metabolism, and elimination.

Absorption

The entry of a drug into plasma from the site of administration.

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Distribution

The movement of the drug from the bloodstream into interstitial and intracellular fluids.

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Metabolism

Biotransformation of the drug by the liver or other tissues.

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Elimination

Removal of the drug and its metabolites from the body through urine, bile, or feces.

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Route of Administration

The pathway by which a drug is delivered to the body, affecting onset and site of action.

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Study Notes

Pharmacology

  • Pharmacology is the study of substances interacting with living systems, primarily through binding to regulatory molecules, activating or inhibiting normal bodily functions.
  • Interactions between drugs and the body are categorized into pharmacodynamic (drug's effect on body) and pharmacokinetic (body's effect on drug) processes.
  • Pharmacodynamic properties classify drugs and determine their appropriateness for treating specific symptoms or diseases.
  • Pharmacokinetics (absorption, distribution, metabolism, elimination) are crucial for choosing and administering drugs, especially for patients with compromised function (e.g., impaired kidneys).

Pharmacokinetics

  • Absorption: Drugs are absorbed from the administration site into the bloodstream (directly or indirectly).
  • Distribution: The drug can then leave the bloodstream and move into interstitial and intracellular fluids.
  • Metabolism: The drug may be biotransformed (metabolized) by the liver or other organs.
  • Elimination: Drugs and metabolites are expelled from the body via urine, bile, or feces.

Drug Administration

  • Drug administration method is based on therapeutic goals (speed of onset, duration of treatment).
  • Common routes include enteral (oral), parenteral (injection/injection), and topical methods.

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Description

Pharmacology studies drug interactions with living systems, focusing on pharmacodynamics (drug effects) and pharmacokinetics (body's effect on the drug). Pharmacokinetics, involving absorption, distribution, metabolism, and elimination, is essential for effective drug administration and dosage adjustments, especially in patients with impaired organ function.

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