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Pharmacology and Biochemistry: Conjugation Reactions

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Pharmacology and Biochemistry: Conjugation Reactions

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Questions and Answers

Which enzyme is responsible for catalyzing acetylation reactions?

Methyl transferase

Amino transferase

Acetyl transferase (correct)

Sulfotransferase

What is the active form of acetic acid involved in acetylation reactions?

Acetyl-CoA (correct)

Phosphoadenosine

S-adenosyl methionine

PAPS

What is the product of the reaction between sulphanilamide and acetic acid?

Acetyl-CoA

PABA

Sulphanilic acid

N-Acetylsulphanilamide (correct)

Which of the following compounds is not conjugated with acetic acid?

Nicotinamide Signup and view all the answers

Where are the enzymes responsible for acetylation reactions mainly located?

Cytosol Signup and view all the answers

What is the purpose of acetylation reactions in the body?

To facilitate the excretion of compounds Signup and view all the answers

What is the primary method of detoxification of foreign substances in the human body?

Oxidation Signup and view all the answers

What is the result of the oxidation of methanol?

Formaldehyde and then formic acid Signup and view all the answers

Which of the following is NOT an example of oxidation?

Aspirin to acetic acid and salicylic acid Signup and view all the answers

What is the result of the reduction of picric acid?

Picramic acid Signup and view all the answers

What type of bond is hydrolyzed in the metabolism of aspirin?

Ester bond Signup and view all the answers

Which of the following is an example of a psychoactive drug that undergoes hydrolysis?

Atropine Signup and view all the answers

What is the primary function of Phase II biotransformation reactions?

To convert lipophilic compounds into water-soluble compounds Signup and view all the answers

Which of the following types of Phase II reactions involves the transfer of a glucuronyl group from UDP-glucuronic acid?

Glucuronidation Signup and view all the answers

What is the role of glucuronyl transferase in glucuronidation?

It acts as a catalyst for the reaction Signup and view all the answers

Which of the following compounds is NOT conjugated with glucuronic acid?

Procaine Signup and view all the answers

What is the purpose of conjugation reactions in Phase II biotransformation?

To convert lipophilic compounds into hydrophilic compounds Signup and view all the answers

How many types of Phase II reactions are mentioned in the text?

6 Signup and view all the answers