Pharmacology and Biochemistry: Conjugation Reactions
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Questions and Answers

Which enzyme is responsible for catalyzing acetylation reactions?

  • Methyl transferase
  • Amino transferase
  • Acetyl transferase (correct)
  • Sulfotransferase

What is the active form of acetic acid involved in acetylation reactions?

  • Acetyl-CoA (correct)
  • Phosphoadenosine
  • S-adenosyl methionine
  • PAPS

What is the product of the reaction between sulphanilamide and acetic acid?

  • Acetyl-CoA
  • PABA
  • Sulphanilic acid
  • N-Acetylsulphanilamide (correct)

Which of the following compounds is not conjugated with acetic acid?

<p>Nicotinamide (C)</p> Signup and view all the answers

Where are the enzymes responsible for acetylation reactions mainly located?

<p>Cytosol (B)</p> Signup and view all the answers

What is the purpose of acetylation reactions in the body?

<p>To facilitate the excretion of compounds (A)</p> Signup and view all the answers

What is the primary method of detoxification of foreign substances in the human body?

<p>Oxidation (C)</p> Signup and view all the answers

What is the result of the oxidation of methanol?

<p>Formaldehyde and then formic acid (B)</p> Signup and view all the answers

Which of the following is NOT an example of oxidation?

<p>Aspirin to acetic acid and salicylic acid (A)</p> Signup and view all the answers

What is the result of the reduction of picric acid?

<p>Picramic acid (C)</p> Signup and view all the answers

What type of bond is hydrolyzed in the metabolism of aspirin?

<p>Ester bond (D)</p> Signup and view all the answers

Which of the following is an example of a psychoactive drug that undergoes hydrolysis?

<p>Atropine (B)</p> Signup and view all the answers

What is the primary function of Phase II biotransformation reactions?

<p>To convert lipophilic compounds into water-soluble compounds (A)</p> Signup and view all the answers

Which of the following types of Phase II reactions involves the transfer of a glucuronyl group from UDP-glucuronic acid?

<p>Glucuronidation (B)</p> Signup and view all the answers

What is the role of glucuronyl transferase in glucuronidation?

<p>It acts as a catalyst for the reaction (A)</p> Signup and view all the answers

Which of the following compounds is NOT conjugated with glucuronic acid?

<p>Procaine (D)</p> Signup and view all the answers

What is the purpose of conjugation reactions in Phase II biotransformation?

<p>To convert lipophilic compounds into hydrophilic compounds (B)</p> Signup and view all the answers

How many types of Phase II reactions are mentioned in the text?

<p>6 (B)</p> Signup and view all the answers

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