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Questions and Answers
Which type of drug will have a low volume of distribution due to being highly plasma protein bound?
Which type of drug will have a low volume of distribution due to being highly plasma protein bound?
- Insulin (correct)
- Thiopentone
- Ethanol
- Paracetamol
When a drug's volume of distribution is very high, exceeding the actual body volume, where is the drug widely distributed?
When a drug's volume of distribution is very high, exceeding the actual body volume, where is the drug widely distributed?
- In muscle tissue
- In the brain
- In adipose tissue (correct)
- In the renal system
Which drug is retained in the vascular compartment due to its low volume of distribution?
Which drug is retained in the vascular compartment due to its low volume of distribution?
- Heparin (correct)
- Warfarin
- Thiopentone
- Ethanol
Drugs with volume of distribution greater than 46 L are mainly restricted to which fluid compartment in the body?
Drugs with volume of distribution greater than 46 L are mainly restricted to which fluid compartment in the body?
What allows Thiopentone to produce anesthesia rapidly after administration?
What allows Thiopentone to produce anesthesia rapidly after administration?
The redistribution of Thiopentone from plasma to other less perfused organs is mainly facilitated by?
The redistribution of Thiopentone from plasma to other less perfused organs is mainly facilitated by?
What does drug distribution refer to?
What does drug distribution refer to?
Which factor does NOT affect drug distribution?
Which factor does NOT affect drug distribution?
What is the main function of the blood-brain barrier?
What is the main function of the blood-brain barrier?
Which factor increases the permeability of the blood-brain barrier?
Which factor increases the permeability of the blood-brain barrier?
Which characteristic of a drug allows it to rapidly cross the blood-brain barrier?
Which characteristic of a drug allows it to rapidly cross the blood-brain barrier?
What are the physiological barriers to drug distribution mentioned in the text?
What are the physiological barriers to drug distribution mentioned in the text?
What type of drugs can pass through the Blood-CSF barrier?
What type of drugs can pass through the Blood-CSF barrier?
Why is it clinically advantageous to inject penicillin intrathecally for the treatment of brain abscess?
Why is it clinically advantageous to inject penicillin intrathecally for the treatment of brain abscess?
How do acidic drugs primarily bind to plasma proteins?
How do acidic drugs primarily bind to plasma proteins?
What is the main mechanism of transfer across the placental barrier for lipid-soluble drugs?
What is the main mechanism of transfer across the placental barrier for lipid-soluble drugs?
What can displacement reactions between drugs lead to?
What can displacement reactions between drugs lead to?
In which conditions would free forms of drugs increase due to decreased albumin levels?
In which conditions would free forms of drugs increase due to decreased albumin levels?
What happens when a drug remains in the muscle and fat for a longer period?
What happens when a drug remains in the muscle and fat for a longer period?
Why are highly plasma protein bound drugs likely to have low volume of distribution?
Why are highly plasma protein bound drugs likely to have low volume of distribution?
What is the effect of alkalinization of urine in acidic drug poisoning?
What is the effect of alkalinization of urine in acidic drug poisoning?
Which factor affects drug absorption by influencing the lipid solubility of a drug?
Which factor affects drug absorption by influencing the lipid solubility of a drug?
How does milk affect the absorption of tetracyclines?
How does milk affect the absorption of tetracyclines?
Which type of drug reactions involve drug displacement with examples?
Which type of drug reactions involve drug displacement with examples?
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