Questions and Answers
What is drug distribution?
The reversible transfer of drug from one location to another within the body
Which of the following is NOT a factor affecting drug distribution?
Metabolism rate
In which organ would a drug typically have decreased distribution due to lower blood flow?
Skin
What property of a drug influences its distribution in the body?
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Where does drug distribution occur within the body?
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Which organ is likely to experience increased drug distribution due to higher blood flow?
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In which clinical problem would drug distribution be most affected due to decreased blood flow?
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In which organs would drug distribution be high due to increased capillary permeability?
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Which factor is NOT responsible for the low distribution of drugs in the blood brain barrier (BBB) and muscles?
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In which clinical issue would patients experience extreme increase in capillary permeability, leading to the high leakage of drugs into the tissues?
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Which type of protein is responsible for binding with particular drugs inside the blood?
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High plasma protein binding leads to:
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Which organ prevents the excretion of albumin into the urine and maintains it in the blood?
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Which type of capillaries have many tight junctions, reducing the ability of things to move out of the blood vessels into the tissue spaces?
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Which factor is dependent on diffusion of the drug out of the blood into the tissue spaces?
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Which clinical problem leads to a decrease in blood flow and affects drug distribution to different tissues?
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