Physiologic Factors of Drug Distribution: Chapter 4 Overview

What is drug distribution?

Which of the following is NOT a factor affecting drug distribution?

In which organ would a drug typically have decreased distribution due to lower blood flow?

What property of a drug influences its distribution in the body?

Where does drug distribution occur within the body?

Which organ is likely to experience increased drug distribution due to higher blood flow?

In which clinical problem would drug distribution be most affected due to decreased blood flow?

In which organs would drug distribution be high due to increased capillary permeability?

Which factor is NOT responsible for the low distribution of drugs in the blood brain barrier (BBB) and muscles?

In which clinical issue would patients experience extreme increase in capillary permeability, leading to the high leakage of drugs into the tissues?

Which type of protein is responsible for binding with particular drugs inside the blood?

High plasma protein binding leads to:

Which organ prevents the excretion of albumin into the urine and maintains it in the blood?

Which type of capillaries have many tight junctions, reducing the ability of things to move out of the blood vessels into the tissue spaces?

Which factor is dependent on diffusion of the drug out of the blood into the tissue spaces?

Which clinical problem leads to a decrease in blood flow and affects drug distribution to different tissues?