Physiologic Factors of Drug Distribution: Chapter 4 Overview
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Questions and Answers

What is drug distribution?

  • The transfer of drug from the blood stream to the tissues
  • The transfer of drug from the body to the systemic circulation
  • The irreversible transfer of drug from one location to another within the body
  • The reversible transfer of drug from one location to another within the body (correct)
  • Which of the following is NOT a factor affecting drug distribution?

  • Metabolism rate (correct)
  • Capillary permeability
  • Protein binding
  • Volume of distribution
  • In which organ would a drug typically have decreased distribution due to lower blood flow?

  • Kidneys
  • Skin (correct)
  • Brain
  • Liver
  • What property of a drug influences its distribution in the body?

    <p>Lipid solubility</p> Signup and view all the answers

    Where does drug distribution occur within the body?

    <p>Both in the blood stream and the tissues</p> Signup and view all the answers

    Which organ is likely to experience increased drug distribution due to higher blood flow?

    <p>Liver</p> Signup and view all the answers

    In which clinical problem would drug distribution be most affected due to decreased blood flow?

    <p>Hypovolemic shock</p> Signup and view all the answers

    In which organs would drug distribution be high due to increased capillary permeability?

    <p>Liver, bone marrow, spleen</p> Signup and view all the answers

    Which factor is NOT responsible for the low distribution of drugs in the blood brain barrier (BBB) and muscles?

    <p>Presence of transporters</p> Signup and view all the answers

    In which clinical issue would patients experience extreme increase in capillary permeability, leading to the high leakage of drugs into the tissues?

    <p>Septic shock</p> Signup and view all the answers

    Which type of protein is responsible for binding with particular drugs inside the blood?

    <p>Albumin</p> Signup and view all the answers

    High plasma protein binding leads to:

    <p>Decrease in the amount of free drug</p> Signup and view all the answers

    Which organ prevents the excretion of albumin into the urine and maintains it in the blood?

    <p>Kidneys</p> Signup and view all the answers

    Which type of capillaries have many tight junctions, reducing the ability of things to move out of the blood vessels into the tissue spaces?

    <p>Continuous capillaries</p> Signup and view all the answers

    Which factor is dependent on diffusion of the drug out of the blood into the tissue spaces?

    <p>High lipophilicity of the drug</p> Signup and view all the answers

    Which clinical problem leads to a decrease in blood flow and affects drug distribution to different tissues?

    <p>Septic shock</p> Signup and view all the answers

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