Podcast
Questions and Answers
What is the main function of drug distribution in pharmacokinetics?
What is the main function of drug distribution in pharmacokinetics?
- To deliver the drug to the target of action (correct)
- To metabolize the drug in the body
- To absorb the drug into the body
- To eliminate the drug from the body
In which compartment are drugs retained if they cannot cross capillary membranes?
In which compartment are drugs retained if they cannot cross capillary membranes?
- Interstitial compartment
- Intravascular compartment (correct)
- Intracellular compartment
- Peripheral (extravascular) compartment
What factors influence drug distribution in pharmacokinetics?
What factors influence drug distribution in pharmacokinetics?
- Lipid solubility and physiochemical properties (correct)
- Plasma protein/tissue binding
- Metabolism and elimination
- Absorption and distribution
Which organs have higher perfusion and blood flow from cardiac output, affecting drug distribution?
Which organs have higher perfusion and blood flow from cardiac output, affecting drug distribution?
What type of drug distribution involves reversible movement of the drug to and from the blood and tissues?
What type of drug distribution involves reversible movement of the drug to and from the blood and tissues?
What is the function of the blood-brain barrier in preventing drug entry into the brain?
What is the function of the blood-brain barrier in preventing drug entry into the brain?
Which type of capillary endothelial cells allows for rapid entry of drugs into the brain?
Which type of capillary endothelial cells allows for rapid entry of drugs into the brain?
What is the purpose of plasma protein binding for drugs in the body?
What is the purpose of plasma protein binding for drugs in the body?
In which condition might a relatively small reduction in albumin binding lead to a large increase in free drug concentration?
In which condition might a relatively small reduction in albumin binding lead to a large increase in free drug concentration?
What is the purpose of back diffusion from well-perfused organs in drug distribution?
What is the purpose of back diffusion from well-perfused organs in drug distribution?
Which of the following factors plays a crucial role in drug distribution in pharmacokinetics?
Which of the following factors plays a crucial role in drug distribution in pharmacokinetics?
In which compartment are drugs retained if they cannot cross cell membranes?
In which compartment are drugs retained if they cannot cross cell membranes?
What type of drug distribution involves reversible movement of the drug to and from the blood and tissues?
What type of drug distribution involves reversible movement of the drug to and from the blood and tissues?
Which type of capillary endothelial cells allows for rapid entry of drugs into the brain?
Which type of capillary endothelial cells allows for rapid entry of drugs into the brain?
Why is lipid solubility considered a crucial factor influencing drug distribution in pharmacokinetics?
Why is lipid solubility considered a crucial factor influencing drug distribution in pharmacokinetics?
Which type of capillary endothelial cells allows for rapid entry of drugs into the brain?
Which type of capillary endothelial cells allows for rapid entry of drugs into the brain?
What is the purpose of back diffusion from well-perfused organs in drug distribution?
What is the purpose of back diffusion from well-perfused organs in drug distribution?
In which condition might a relatively small reduction in albumin binding lead to a large increase in free drug concentration?
In which condition might a relatively small reduction in albumin binding lead to a large increase in free drug concentration?
What factors influence drug distribution in pharmacokinetics?
What factors influence drug distribution in pharmacokinetics?
In which compartment are drugs retained if they cannot cross capillary membranes?
In which compartment are drugs retained if they cannot cross capillary membranes?
