Pharmacokinetics 2: Absorption, Distribution, and Metabolism

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What is the main function of drug distribution in pharmacokinetics?

To deliver the drug to the target of action (correct)

To metabolize the drug in the body

To absorb the drug into the body

To eliminate the drug from the body

In which compartment are drugs retained if they cannot cross capillary membranes?

Interstitial compartment

Intravascular compartment (correct)

Intracellular compartment

Peripheral (extravascular) compartment

What factors influence drug distribution in pharmacokinetics?

Lipid solubility and physiochemical properties (correct)

Plasma protein/tissue binding

Metabolism and elimination

Absorption and distribution

Which organs have higher perfusion and blood flow from cardiac output, affecting drug distribution?

Brain and lungs Signup and view all the answers

What type of drug distribution involves reversible movement of the drug to and from the blood and tissues?

Two-compartment distribution Signup and view all the answers

What is the function of the blood-brain barrier in preventing drug entry into the brain?

It consists of tightly bound capillary endothelial cells and efflux pumps, preventing many drugs from entering the brain. Signup and view all the answers

Which type of capillary endothelial cells allows for rapid entry of drugs into the brain?

Fenestrated, discontinuous capillary endothelial cells in the brain Signup and view all the answers

What is the purpose of plasma protein binding for drugs in the body?

It serves as a reservoir that prolongs drug action or causes local toxicity. Signup and view all the answers

In which condition might a relatively small reduction in albumin binding lead to a large increase in free drug concentration?

Liver failure Signup and view all the answers

What is the purpose of back diffusion from well-perfused organs in drug distribution?

To maintain equilibrium between free and bound drug concentration Signup and view all the answers

Which of the following factors plays a crucial role in drug distribution in pharmacokinetics?

Capillary permeability Signup and view all the answers

In which compartment are drugs retained if they cannot cross cell membranes?

Extracellular compartment Signup and view all the answers

What type of drug distribution involves reversible movement of the drug to and from the blood and tissues?

Bidirectional distribution Signup and view all the answers

Which type of capillary endothelial cells allows for rapid entry of drugs into the brain?

Fenestrated capillaries Signup and view all the answers

Why is lipid solubility considered a crucial factor influencing drug distribution in pharmacokinetics?

It influences the drug's ability to cross biological barriers Signup and view all the answers

Which type of capillary endothelial cells allows for rapid entry of drugs into the brain?

Fenestrated and discontinuous Signup and view all the answers

What is the purpose of back diffusion from well-perfused organs in drug distribution?

To redistribute drugs into poorly-perfused organs Signup and view all the answers

In which condition might a relatively small reduction in albumin binding lead to a large increase in free drug concentration?

Liver disease with decreased albumin concentration Signup and view all the answers

What factors influence drug distribution in pharmacokinetics?

Permeability of capillary membranes Signup and view all the answers

In which compartment are drugs retained if they cannot cross capillary membranes?

Peripheral compartment Signup and view all the answers

Pharmacokinetics 2: Absorption, Distribution, and Metabolism

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Questions and Answers

What is the main function of drug distribution in pharmacokinetics?

In which compartment are drugs retained if they cannot cross capillary membranes?

What factors influence drug distribution in pharmacokinetics?

Which organs have higher perfusion and blood flow from cardiac output, affecting drug distribution?

What type of drug distribution involves reversible movement of the drug to and from the blood and tissues?

What is the function of the blood-brain barrier in preventing drug entry into the brain?

Which type of capillary endothelial cells allows for rapid entry of drugs into the brain?

What is the purpose of plasma protein binding for drugs in the body?

In which condition might a relatively small reduction in albumin binding lead to a large increase in free drug concentration?

What is the purpose of back diffusion from well-perfused organs in drug distribution?

Which of the following factors plays a crucial role in drug distribution in pharmacokinetics?

In which compartment are drugs retained if they cannot cross cell membranes?

What type of drug distribution involves reversible movement of the drug to and from the blood and tissues?

Which type of capillary endothelial cells allows for rapid entry of drugs into the brain?

Why is lipid solubility considered a crucial factor influencing drug distribution in pharmacokinetics?

Which type of capillary endothelial cells allows for rapid entry of drugs into the brain?

What is the purpose of back diffusion from well-perfused organs in drug distribution?

In which condition might a relatively small reduction in albumin binding lead to a large increase in free drug concentration?

What factors influence drug distribution in pharmacokinetics?

In which compartment are drugs retained if they cannot cross capillary membranes?

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