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Questions and Answers
What is the effectiveness of birth control injections in family planning?
What is the effectiveness of birth control injections in family planning?
What is the effectiveness of a male condom in family planning?
What is the effectiveness of a male condom in family planning?
What does STI stand for?
What does STI stand for?
Which type of hospital is designed to provide care for patients with major injuries?
Which type of hospital is designed to provide care for patients with major injuries?
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If the dose administered is incorrect, what type of error is it classified as?
If the dose administered is incorrect, what type of error is it classified as?
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Which of the following focuses on improving overall health in populations?
Which of the following focuses on improving overall health in populations?
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What is pharmacotherapy?
What is pharmacotherapy?
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What type of medication error occurs if Amoxycillin suspension is incorrectly prepared with milk?
What type of medication error occurs if Amoxycillin suspension is incorrectly prepared with milk?
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What is the correct ratio of oil, water, and acacia for preparing an emulsion by the bottle method?
What is the correct ratio of oil, water, and acacia for preparing an emulsion by the bottle method?
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Which dosage form is described as an opaque, viscous, spreadable semisolid that contains over 20% water?
Which dosage form is described as an opaque, viscous, spreadable semisolid that contains over 20% water?
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Which document details the steps and activities of a process or procedure?
Which document details the steps and activities of a process or procedure?
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Which of these best represents the mirror of a pharmaceutical company?
Which of these best represents the mirror of a pharmaceutical company?
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Who is primarily responsible for maintaining product quality?
Who is primarily responsible for maintaining product quality?
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Which metal container is considered the cheapest option?
Which metal container is considered the cheapest option?
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What is the main limitation associated with glass containers?
What is the main limitation associated with glass containers?
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What type of glass is ideal for packaging light-sensitive ingredients?
What type of glass is ideal for packaging light-sensitive ingredients?
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What is one of the adverse effects of gas permeation through plastic containers on drugs?
What is one of the adverse effects of gas permeation through plastic containers on drugs?
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Which class of chemical agents is primarily used to maintain the pH of injections?
Which class of chemical agents is primarily used to maintain the pH of injections?
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What is the preferred pH for preparing ophthalmic products to avoid eye discomfort?
What is the preferred pH for preparing ophthalmic products to avoid eye discomfort?
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Which of the following is an advantage of using plastic containers?
Which of the following is an advantage of using plastic containers?
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What does NP refer to concerning parenteral products?
What does NP refer to concerning parenteral products?
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Which type of ray is most commonly utilized in radiation sterilization?
Which type of ray is most commonly utilized in radiation sterilization?
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Which item is not considered a health accessory?
Which item is not considered a health accessory?
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At what age should the BCG vaccine be administered?
At what age should the BCG vaccine be administered?
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Which binder is most suitable for manufacturing Ciprofloxacin tablets by wet granulation?
Which binder is most suitable for manufacturing Ciprofloxacin tablets by wet granulation?
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What is the purpose of wet screening in the wet granulation process?
What is the purpose of wet screening in the wet granulation process?
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Which type of active pharmaceutical ingredients (APIs) are unsuitable for wet granulation?
Which type of active pharmaceutical ingredients (APIs) are unsuitable for wet granulation?
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Which substance is typically added to a primary solvent to enhance the solubility of a poorly soluble compound?
Which substance is typically added to a primary solvent to enhance the solubility of a poorly soluble compound?
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During the preparation of an emulsion using the wet gum method, what is the first step?
During the preparation of an emulsion using the wet gum method, what is the first step?
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Which equipment is specifically used for slugging in tablet manufacturing?
Which equipment is specifically used for slugging in tablet manufacturing?
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Which ingredient can be added to a mixture to reduce sedimentation and enhance suspensibility of a powdered syrup?
Which ingredient can be added to a mixture to reduce sedimentation and enhance suspensibility of a powdered syrup?
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Which of the following is a disadvantage of using plastic materials?
Which of the following is a disadvantage of using plastic materials?
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Study Notes
PHARMACEUTICS - INDUSTRIAL AND QUALITY CONTROL
- Wet Granulation Binder: Magnesium stearate is a suitable binder for Ciprofloxacin tablets manufactured via wet granulation.
- Paracetamol Tablet Disintegrant: Microcrystalline cellulose is a common disintegrant used in direct compression Paracetamol tablet manufacturing.
- Powder Flow Improvement: Magnesium stearate, talcum, titanium dioxide, and silicon dioxide are materials used to improve powder flow in tablet compression machines.
- Wet Screening in Wet Granulation: Wet screening in tablet wet granulation disrupts lumps, converts large dry particles into smaller ones and mixes the resulting granules effectively.
EQUIPMENT AND METHODS
- Slugging Equipment: Z.P-19 is used for slugging.
- APIs Unsuitable for Wet Granulation: Heat-labile, heat-sensitive, and hygroscopic APIs are not suitable for wet granulation.
- Plastic Material Disadvantages: Plastic materials have disadvantages like stress cracking.
- Solubility Enhancement: Co-solvents are added to primary solvents in small amounts to increase the poor solubility compound's solubility.
- Antioxidant: Methyl paraben, sodium propyl paraben, sodium acetate, and vitamin C are used as antioxidants in pharmaceutical preparations.
GENERAL PHARMACEUTICAL PRINCIPLES
-
Emulsion Preparation:
- Wet gum method: First step involve trituration of one part water and one part acacia mixture.
- Dry gum method: First step involve trituration of one part water and one part acacia mixture.
- Emulsion Ratio (Bottle Method): Oil:water:nonio - 1:1:2
- Opaque Emulsion Dosage Forms: Opaque, viscous, relatively soft, consistently spreadable, semisolid emulsion dosage forms are discussed.
- Written Process Documents: Work instructions, standard operating procedures, GMP guidelines, and WHO instructions are types of written documents.
PHARMACEUTICAL CONTAINERS AND MATERIALS
- Cheapest Metal Container: Steel is the cheapest metal container.
- Glass Container Limitation: Glass containers are not UV light proof, and are fragile.
- Parentral Container Rubber: Butyl rubber is a common type of rubber used in sealing and packaging parentral containers.
- Light Sensitive Ingredients: Amber glass is used for light-sensitive ingredients during primary packaging.
PHARMACEUTICAL PREPARATIONS
- Adverse Effects of Permeation: Permeation of gases, vapors, or liquid through plastic containers can cause adverse effects on drugs.
- pH Maintenance in Injections: Chemicals like solvents, antioxidants, buffers, and preservatives are used to maintain the pH of injections.
- Ophthalmic Product pH: 6.8 pH is a preferred pH in ophthalmic product preparation.
HOSPITAL AND COMMUNITY PHARMACY
- Health Accessories: Blanket, wheel chair, hospital beds, and cables are health accessories.
- Sterile Preparations: Phenol, lactic acid, sodium hydroxide, and sodium chloride are examples of tonicity modifiers in sterile preparations.
GENERAL HEALTH
- Communicable Disease: Congenital heart failure, pulmonary hypertension, hypertension, and chickenpox are communicable diseases.
- Non-Communicable Disease: Examples include AIDS, Ebola, COVID, and cancer..
- Vaccine Administration: The BCG vaccine administration is discussed with respect to age.
- Child Immunization Programs: WHO's Expanded Program on Immunization (EPI) is illustrated.
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Description
This quiz covers essential aspects of pharmaceutics, including the role of various binders, disintegrants, and materials used in tablet manufacturing. Explore the techniques involved in wet granulation and the equipment necessary for optimal production. Test your knowledge on the suitability of different APIs for wet granulation processes.
