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Questions and Answers
What does micromeritics primarily focus on?
What does micromeritics primarily focus on?
- Electrical properties of particles
- Mechanical properties of particles
- Particle size and size distribution (correct)
- Chemical composition of particles
In pharmaceuticals, why is particle size important?
In pharmaceuticals, why is particle size important?
- It determines the chemical reactivity of the drug
- It affects the electrical charge of the drug
- It primarily influences the color of the drug
- It plays a key role in dissolution and therapeutic efficacy (correct)
What is a key property of powders in micromeritics?
What is a key property of powders in micromeritics?
- Electrical conductivity
- Color
- Porosity (correct)
- Magnetic susceptibility
Why are micromeritics properties of powders important in pharmaceuticals?
Why are micromeritics properties of powders important in pharmaceuticals?
Which technique is ideal for blending eutectic formers in pharmaceutical powders?
Which technique is ideal for blending eutectic formers in pharmaceutical powders?
What particle size do fine grinding mills typically provide in pharmaceutical powder formulation?
What particle size do fine grinding mills typically provide in pharmaceutical powder formulation?
Which glidant is known to enhance flowability in pharmaceutical powders?
Which glidant is known to enhance flowability in pharmaceutical powders?
Which method for particle size analysis is mentioned in the text?
Which method for particle size analysis is mentioned in the text?
How is powder flowability defined?
How is powder flowability defined?
What governs the measurement of particle surface area?
What governs the measurement of particle surface area?
What is porosity a measure of in powder material?
What is porosity a measure of in powder material?
What impacts powder flowability?
What impacts powder flowability?
How are density measurements important for tablet manufacture?
How are density measurements important for tablet manufacture?
What is used to measure powder flow properties?
What is used to measure powder flow properties?
How is particle shape mentioned to impact behavior in biological systems?
How is particle shape mentioned to impact behavior in biological systems?
What can large increases in surface area of particles affect?
What can large increases in surface area of particles affect?
How is pore size measurement mentioned to be done?
How is pore size measurement mentioned to be done?
What is powder flowability influenced by?
What is powder flowability influenced by?
What influences the flowability of powders?
What influences the flowability of powders?
Which method for determining particle size involves a set of stacked sieves in a column with mesh openings decreasing in size from top to bottom?
Which method for determining particle size involves a set of stacked sieves in a column with mesh openings decreasing in size from top to bottom?
What is the desired particle size distribution in pharmaceutical preparations?
What is the desired particle size distribution in pharmaceutical preparations?
Which law applies to the sedimentation method for determining particle size?
Which law applies to the sedimentation method for determining particle size?
What is the main influence of particle size and distribution on in pharmaceutical preparations?
What is the main influence of particle size and distribution on in pharmaceutical preparations?
What does the sieving method involve for particles larger than 50 to 100 µm in diameter?
What does the sieving method involve for particles larger than 50 to 100 µm in diameter?
What do the majority of particles in solid dosage forms tend to be in terms of shape and size?
What do the majority of particles in solid dosage forms tend to be in terms of shape and size?
What is the sedimentation method for determining particle size based on?
What is the sedimentation method for determining particle size based on?
What is the best method for fine insoluble particles in pharmaceutical preparations?
What is the best method for fine insoluble particles in pharmaceutical preparations?
What does the sieving method involve for particles smaller than 50 to 100 µm in diameter?
What does the sieving method involve for particles smaller than 50 to 100 µm in diameter?
What is the main purpose of the sedimentation method for determining particle size?
What is the main purpose of the sedimentation method for determining particle size?
What is the primary factor deciding particle size distribution?
What is the primary factor deciding particle size distribution?
What method involves a set of stacked sieves in a column, with mesh openings decreasing in size from top to bottom?
What method involves a set of stacked sieves in a column, with mesh openings decreasing in size from top to bottom?
Study Notes
Particle Size and Distribution in Pharmaceutical Preparations
- Particle size and distribution influence powder mixing, compression, wetability, and mechanical flow in solid dosage forms.
- Narrow particle size distribution is desired in pharmaceutical preparations, as wide size distribution leads to inaccurate dosing and inconsistent performance.
- The majority of particles in solid dosage forms are irregular in shape and size.
- Factors deciding particle size distribution include frequency, mean, and standard deviation, and the distribution curve is obtained by plotting frequency against the arithmetic mean of the particle size group.
- Pharmaceutical powders often do not possess normal particle size distribution.
- Methods for determining particle size include electron microscopy, optical microscopy, Coulter counter, and sieving method.
- The sieving method involves a set of stacked sieves in a column, with mesh openings decreasing in size from top to bottom, and the bottom pan catching particles that pass through all sieves.
- The sieving method is best for particles larger than 50 to 100 µm in diameter, and the initial sample size is important to produce consistent results.
- Wet sieving may be appropriate for fine insoluble particles, as the top sieve is washed with water to help move particles to the appropriate sieve.
- Sedimentation method involves the tendency for particles in suspension to settle out of the fluid and come to rest against a barrier, and the movement through the fluid is used to measure particle size.
- Stoke’s Law applies to the sedimentation method, with the velocity of sedimentation being used to measure particle size.
- The sedimentation method utilizes an Andreasen pipette, a graduated cylinder, and controlled temperature for particle size determination.
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Description
Test your knowledge of particle size and distribution in pharmaceutical preparations with this quiz. Explore the factors influencing particle size distribution, methods for determining particle size, and the impact of size and distribution on pharmaceutical formulations.
