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Questions and Answers
Which method provides powders smaller than 200 mesh?
What is the purpose of glidants such as mag+ stearate, starch, and talc in pharmaceutical powders?
Which technique is ideal for blending eutectic formers and does not involve particle size reduction?
What does micromeritics primarily focus on?
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In what state are most pharmaceutical ingredients found?
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Why is particle size important in pharmaceuticals?
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What is the main purpose of determining the properties of powders in pharmaceuticals?
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What method is used to determine particle size in pharmaceuticals?
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How does particle shape impact surface area?
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Why is particle shape important in drug development?
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What influences the behavior of colloids in biological systems?
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How does surface area affect the behavior of drug delivery systems?
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What is the measure of void volume in a powder material called?
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How is porosity expressed?
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What influences the density of powders?
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What is crucial for assessing the flow properties of powders?
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How is powder flowability influenced?
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What factors decide particle size distribution in pharmaceutical preparations?
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What are the methods for assessing flow properties?
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Why is a narrow particle size distribution desired in pharmaceutical preparations?
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What does the Hausner ratio indicate?
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Which method is best for particles larger than 50 to 100 µm in diameter?
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What is the purpose of the wet sieving method?
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What does the sedimentation method involve?
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What is used to calculate the velocity of sedimentation in the sedimentation method?
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Which method involves the use of an Andreasen pipette and a graduated cylinder?
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What is the main purpose of the sieving method in particle size analysis?
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Why is a normal distribution curve often not achieved in pharmaceutical powders?
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What is the initial sample size important in the sieving method?
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Which method is used to determine particle size using a Coulter counter?
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Which method is appropriate for separating particles into size fractions based on the time of sedimentation?
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Study Notes
Particle Size Analysis in Pharmaceutical Preparations
- Particle size and distribution in solid dosage forms affect powder mixing, compression, wetability, and mechanical flow.
- Narrow particle size distribution is desired in pharmaceutical preparations, as wide distribution can lead to inaccurate dosing and inconsistent performance.
- Factors that decide particle size distribution include frequency, mean, and standard deviation, and the distribution curve is obtained by plotting frequency against the arithmetic mean of the particle size group.
- Normal distribution curve in pharmaceutical powders is often not achieved due to irregular shape and size of particles.
- Particle size can be determined using electron microscopy, optical microscopy, Coulter counter, and sieving method.
- Sieving method involves stacked sieves with mesh openings decreasing in size from top to bottom, and it is best for particles larger than 50 to 100 µm in diameter.
- The sample of known weight is placed at the top of the sieves, and the weighted sample is placed in the top sieve.
- The initial sample size is important in the sieving method, as too large or overloading the sieve may affect the results.
- Wet sieving may be appropriate for fine insoluble particles, where the top sieve is washed with water to move particles to appropriate sieves.
- Sedimentation method involves the tendency for particles in suspension to settle out of the fluid and come to rest against a barrier, and the separation of particles into size fractions depends on the time of sedimentation.
- Stoke's Law is applied in the sedimentation method to calculate the velocity of sedimentation based on various factors.
- The sedimentation method also involves the use of an Andreasen pipette, a graduated cylinder, and samples removed at controlled temperatures for analysis.
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Description
Test your knowledge of particle size analysis in pharmaceutical preparations with this quiz. Explore the methods and factors influencing particle size distribution in solid dosage forms, and learn about techniques such as sieving, sedimentation, and microscopy used to determine particle size.
