Pharm II Dextenza: Anti-Inflammatory Drugs Quiz

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What is the duration of the effect of the dexamethasone intravitreal implant (Ozurdex)?

1-3 months (correct)

1-2 weeks

3-6 months

6-12 months

What is the purpose of the dexamethasone intravitreal implant (Ozurdex)?

To treat allergic conjunctivitis

To treat cataract surgery

For inflammation and macular edema (diabetic or VO) (correct)

All of the above

What is the form of the dexamethasone intravitreal implant (Ozurdex)?

Tablet

Liquid

Solid polymer sustained release and dissolvable (correct)

Ointment

What is the relationship between the duration of the dexamethasone insert and the patient's relief after cataract surgery?

The patient feels relief for a longer duration than the insert lasts (45 days) Signup and view all the answers

What is the purpose of steroids in the treatment of macular edema?

To decrease neovascularization and linkage from BV Signup and view all the answers

What is the structural relationship of fluorometholone to progesterone?

Fluorometholone is structurally related to progesterone Signup and view all the answers

What is the potential of fluorometholone to elevate intraocular pressure (IOP)?

Fluorometholone has a relatively low potential to elevate IOP Signup and view all the answers

What is the most common adverse reaction associated with DEXTENZA?

Headache Signup and view all the answers

Which ocular issue was NOT associated with allergic conjunctivitis in patients using DEXTENZA?

Corneal edema Signup and view all the answers

What percentage of patients experienced increased intraocular pressure (IOP) following ophthalmic surgery with DEXTENZA?

6% Signup and view all the answers

What significant improvement was noted as early as Day 4 in patients with allergic conjunctivitis treated with DEXTENZA?

Reduction in inflammatory cells Signup and view all the answers

Which symptom associated with allergic conjunctivitis was reported in all patients treated with DEXTENZA?

Pain relief Signup and view all the answers

Which condition showed potential for relief of ocular itching for up to 4 weeks when treated with DEXTENZA?

Allergic conjunctivitis Signup and view all the answers

What is the main reason why Medrysone is considered the weakest ophthalmic steroid?

Limited corneal penetration Signup and view all the answers

Why is Medrysone no longer available in the US market?

Due to causing a rise in intraocular pressure Signup and view all the answers

What distinguishes Loteprednol from other steroids like Medrysone?

Has a ketone group at position 20 Signup and view all the answers

What is the main advantage of Loteprednol being a site-specific/soft drug?

Gets to the receptor site and does the job without causing a rise in IOP Signup and view all the answers

Why is Loteprednol less likely to cause an increase in intraocular pressure compared to other steroids?

Ketone group at position 20 is absent Signup and view all the answers

Which steroid is suitable for treating superficial ocular inflammations like allergic conjunctivitis?

Medrysone Signup and view all the answers

What feature of Loteprednol possibly contributes to its low chance of increasing intraocular pressure?

Ketone group at position 20 is absent Signup and view all the answers

Why is Medrysone considered no longer available in the US despite being a synthetic derivative of progesterone?

Due to causing a rise in intraocular pressure Signup and view all the answers

What is the abbreviation 'FML' referring to in the context of the text?

An abbreviation not related to cortisol like the other steroids, but related to progesterone Signup and view all the answers

What is the key difference between the fluorometholone alcohol and acetate formulations mentioned in the text?

The fluorometholone acetate formulations have higher anti-inflammatory efficacy compared to the alcohol formulations Signup and view all the answers

Which fluorometholone product is indicated to have a higher concentration compared to the others mentioned?

Fluorometholone alcohol 0.25% Signup and view all the answers

Based on the information provided, which steroid appears to have the highest anti-inflammatory efficacy in the presence of an intact epithelium?

Prednisolone acetate 1% Signup and view all the answers

What is the key difference in anti-inflammatory efficacy between the fluorometholone alcohol 0.1% and 0.25% formulations?

The 0.25% formulation has significantly higher anti-inflammatory efficacy compared to the 0.1% formulation Signup and view all the answers

Which statement best describes the relationship between the fluorometholone alcohol and acetate formulations in terms of anti-inflammatory efficacy?

The fluorometholone acetate formulations have higher anti-inflammatory efficacy than the alcohol formulations Signup and view all the answers

What is the key advantage of the fluorometholone formulations mentioned in the text compared to other steroid formulations?

They stay on the ocular surface and do not significantly enter the eye, making them a good option for dry eye patients with inflammation Signup and view all the answers