28 Questions
What is the duration of the effect of the dexamethasone intravitreal implant (Ozurdex)?
1-3 months
What is the purpose of the dexamethasone intravitreal implant (Ozurdex)?
For inflammation and macular edema (diabetic or VO)
What is the form of the dexamethasone intravitreal implant (Ozurdex)?
Solid polymer sustained release and dissolvable
What is the relationship between the duration of the dexamethasone insert and the patient's relief after cataract surgery?
The patient feels relief for a longer duration than the insert lasts (45 days)
What is the purpose of steroids in the treatment of macular edema?
To decrease neovascularization and linkage from BV
What is the structural relationship of fluorometholone to progesterone?
Fluorometholone is structurally related to progesterone
What is the potential of fluorometholone to elevate intraocular pressure (IOP)?
Fluorometholone has a relatively low potential to elevate IOP
What is the most common adverse reaction associated with DEXTENZA?
Headache
Which ocular issue was NOT associated with allergic conjunctivitis in patients using DEXTENZA?
Corneal edema
What percentage of patients experienced increased intraocular pressure (IOP) following ophthalmic surgery with DEXTENZA?
6%
What significant improvement was noted as early as Day 4 in patients with allergic conjunctivitis treated with DEXTENZA?
Reduction in inflammatory cells
Which symptom associated with allergic conjunctivitis was reported in all patients treated with DEXTENZA?
Pain relief
Which condition showed potential for relief of ocular itching for up to 4 weeks when treated with DEXTENZA?
Allergic conjunctivitis
What is the main reason why Medrysone is considered the weakest ophthalmic steroid?
Limited corneal penetration
Why is Medrysone no longer available in the US market?
Due to causing a rise in intraocular pressure
What distinguishes Loteprednol from other steroids like Medrysone?
Has a ketone group at position 20
What is the main advantage of Loteprednol being a site-specific/soft drug?
Gets to the receptor site and does the job without causing a rise in IOP
Why is Loteprednol less likely to cause an increase in intraocular pressure compared to other steroids?
Ketone group at position 20 is absent
Which steroid is suitable for treating superficial ocular inflammations like allergic conjunctivitis?
Medrysone
What feature of Loteprednol possibly contributes to its low chance of increasing intraocular pressure?
Ketone group at position 20 is absent
Why is Medrysone considered no longer available in the US despite being a synthetic derivative of progesterone?
Due to causing a rise in intraocular pressure
What is the abbreviation 'FML' referring to in the context of the text?
An abbreviation not related to cortisol like the other steroids, but related to progesterone
What is the key difference between the fluorometholone alcohol and acetate formulations mentioned in the text?
The fluorometholone acetate formulations have higher anti-inflammatory efficacy compared to the alcohol formulations
Which fluorometholone product is indicated to have a higher concentration compared to the others mentioned?
Fluorometholone alcohol 0.25%
Based on the information provided, which steroid appears to have the highest anti-inflammatory efficacy in the presence of an intact epithelium?
Prednisolone acetate 1%
What is the key difference in anti-inflammatory efficacy between the fluorometholone alcohol 0.1% and 0.25% formulations?
The 0.25% formulation has significantly higher anti-inflammatory efficacy compared to the 0.1% formulation
Which statement best describes the relationship between the fluorometholone alcohol and acetate formulations in terms of anti-inflammatory efficacy?
The fluorometholone acetate formulations have higher anti-inflammatory efficacy than the alcohol formulations
What is the key advantage of the fluorometholone formulations mentioned in the text compared to other steroid formulations?
They stay on the ocular surface and do not significantly enter the eye, making them a good option for dry eye patients with inflammation
Test your knowledge on the adverse reactions of DEXTENZA (dexamethasone ophthalmic insert) 0.4 mg, including its effects following ophthalmic surgery and allergic conjunctivitis. Identify the percentages of common side effects such as headache, anterior chamber inflammation, increased IOP, and reduced visual acuity.
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