Pharmacology: Anti-Inflammatory Steroids Basics

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Which steroid formulation has the greatest anti-inflammatory effect compared to the others?

Steroid acetate derivatives (correct)

Steroid alcohol derivatives

Steroid salt formulations (sodium phosphate, hydrochloride)

All steroid formulations have equal anti-inflammatory effects

How does the presence of an intact corneal epithelium and inflammation affect the penetration of different steroid formulations into the anterior chamber?

Phosphate formulations have greater penetration than acetate formulations in the presence of an intact epithelium and inflammation.

Alcohol formulations have the greatest penetration regardless of epithelial integrity or presence of inflammation.

Acetate formulations have greater penetration than phosphate formulations in the presence of an intact epithelium and inflammation. (correct)

Steroid formulation penetration is not affected by the presence of an intact epithelium or inflammation.

Why are steroid suspensions commonly used for ophthalmic formulations?

Most steroids are inherently delivered as suspensions. (correct)

Suspensions provide a more stable formulation.

Suspensions improve patient compliance.

Suspensions allow for better drug solubility.

Which steroid formulation property is associated with greater corneal penetration?

Increased lipophilicity/fat solubility Signup and view all the answers

How does the presence of an intact epithelium affect the bioavailability of different steroid formulations?

Intact epithelium increases the bioavailability of acetate and alcohol formulations, but decreases the bioavailability of phosphate formulations. Signup and view all the answers

Which steroid formulation has the highest anti-inflammatory efficacy when the epithelium is intact?

Prednisolone acetate 1% Signup and view all the answers

Which steroid property contributes to increased affinity for the receptor?

Increased lipophilicity Signup and view all the answers

Why is the phosphate derivative of prednisolone less preferred for treating anterior segment inflammation compared to the acetate derivative?

The phosphate derivative has higher corneal penetration. Signup and view all the answers

Which steroid formulation has the highest anti-inflammatory efficacy when the epithelium is absent?

Dexamethasone alcohol 0.1% Signup and view all the answers

Which steroid is considered the exception to being ketone-based?

Loteprednol Signup and view all the answers

Which of the following is the primary reason why steroids may mask the symptoms and underlying disease?

Steroids go after the inflammation, not the actual disease Signup and view all the answers

What is the primary reason why topical or periocular steroid administration has fewer systemic adverse effects compared to intralesion injection?

Topical and periocular steroids have lower bioavailability Signup and view all the answers

Which of the following is the most likely explanation for the paradoxical exacerbation of uveitis with steroid treatment?

The underlying mechanism for the paradoxical effect is not well understood Signup and view all the answers

Which property of steroids is most likely responsible for the observed difference in corneal epithelial healing between black and white patients?

Lipid solubility Signup and view all the answers

Which of the following is the most likely reason for the temporary mydriasis observed with topical steroid administration?

The vehicle used in the topical steroid formulation Signup and view all the answers

Which of the following statements about steroid bioavailability is correct?

Lipid-soluble steroids have higher bioavailability than water-soluble steroids when administered topically. Signup and view all the answers

Which of the following factors primarily determines the anti-inflammatory efficacy of a steroid?

The glucocorticoid receptor binding affinity. Signup and view all the answers

Which of the following steroid formulations is most suitable for the treatment of posterior segment inflammation?

Intravitreal injections. Signup and view all the answers

Which of the following properties of steroids contributes to their potential for causing cataracts?

Their ability to disrupt lens protein structure. Signup and view all the answers

Which of the following statements about steroid formulations is correct?

Intravitreal injections are preferred over subconjunctival injections for posterior segment delivery. Signup and view all the answers

Which of the following statements about steroid formulations and bioavailability is correct?

Water-soluble salts form solutions and do not require shaking, while lipid-soluble derivatives form suspensions that need to be shaken before use. Signup and view all the answers

Which of the following factors affects the penetration of steroids through the cornea?

All of the above. Signup and view all the answers

Based on the anti-inflammatory efficacy data provided, which steroid formulation has the highest efficacy when the corneal epithelium is intact?

Dexamethasone acetate 0.1% Signup and view all the answers

What is the primary difference between lipid-soluble and water-soluble steroid formulations in terms of their ability to penetrate the cornea?

Lipid-soluble steroids penetrate better through the hydrophobic corneal epithelium and endothelium lipid layers, while water-soluble steroids penetrate better through the hydrophilic corneal stroma. Signup and view all the answers

According to the anti-inflammatory efficacy data, which steroid formulation has the lowest efficacy when the corneal epithelium is absent?

Dexamethasone phosphate 0.1% Signup and view all the answers

Which statement about prednisolone acetate suspension is correct?

The 1% suspension (Pred Forte) has smaller and more uniform particles than the 0.125% suspension. Signup and view all the answers

Which statement accurately describes the bioavailability of dexamethasone alcohol and dexamethasone phosphate?

Dexamethasone alcohol has higher anti-inflammatory activity and bioavailability on intact epithelium compared to dexamethasone phosphate. Signup and view all the answers

Which property distinguishes dexamethasone from prednisolone?

Dexamethasone is a ketone-based steroid, while prednisolone is an alcohol-based steroid. Signup and view all the answers

Which statement accurately compares the anti-inflammatory efficacy of lipid-soluble and water-soluble steroid formulations?

Lipid-soluble steroid formulations have higher anti-inflammatory efficacy than water-soluble formulations. Signup and view all the answers

Which statement accurately describes the properties of prednisolone sodium phosphate 1% solution?

It is a generic formulation with larger and less uniform particles compared to brand name versions. Signup and view all the answers

Which of the following is the primary reason that steroid suspensions are commonly used for ophthalmic formulations?

Suspensions allow for controlled and sustained release of the steroid. Signup and view all the answers

Which steroid property contributes to its increased affinity for the glucocorticoid receptor?

Lipophilicity Signup and view all the answers

Why is the phosphate derivative of prednisolone less preferred for treating anterior segment inflammation compared to the acetate derivative?

The phosphate derivative is less lipophilic and has reduced corneal penetration. Signup and view all the answers

Which steroid formulation has the greatest anti-inflammatory effect in the presence of an intact corneal epithelium?

Lipophilic steroid esters Signup and view all the answers

How does the presence of an intact corneal epithelium affect the bioavailability of different steroid formulations in the anterior chamber?

Intact epithelium increases the bioavailability of lipophilic steroid formulations but decreases the bioavailability of hydrophilic steroid formulations. Signup and view all the answers

Which steroid is considered the exception to being ketone-based?

Hydrocortisone Signup and view all the answers

Which steroid formulation property is associated with greater corneal penetration?

Increased lipophilicity Signup and view all the answers

Which steroid formulation has the highest anti-inflammatory efficacy when the corneal epithelium is absent?

Steroid solutions Signup and view all the answers

How does the presence of inflammation affect the penetration of different steroid formulations into the anterior chamber?

Inflammation increases the penetration of all steroid formulations. Signup and view all the answers

Which steroid formulation has the greatest anti-inflammatory effect compared to the others?

Lipophilic steroid esters Signup and view all the answers

Pharmacology: Anti-Inflammatory Steroids Basics

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Questions and Answers

Which steroid formulation has the greatest anti-inflammatory effect compared to the others?

How does the presence of an intact corneal epithelium and inflammation affect the penetration of different steroid formulations into the anterior chamber?

Why are steroid suspensions commonly used for ophthalmic formulations?

Which steroid formulation property is associated with greater corneal penetration?

How does the presence of an intact epithelium affect the bioavailability of different steroid formulations?

Which steroid formulation has the highest anti-inflammatory efficacy when the epithelium is intact?

Which steroid property contributes to increased affinity for the receptor?

Why is the phosphate derivative of prednisolone less preferred for treating anterior segment inflammation compared to the acetate derivative?

Which steroid formulation has the highest anti-inflammatory efficacy when the epithelium is absent?

Which steroid is considered the exception to being ketone-based?

Which of the following is the primary reason why steroids may mask the symptoms and underlying disease?

What is the primary reason why topical or periocular steroid administration has fewer systemic adverse effects compared to intralesion injection?

Which of the following is the most likely explanation for the paradoxical exacerbation of uveitis with steroid treatment?

Which property of steroids is most likely responsible for the observed difference in corneal epithelial healing between black and white patients?

Which of the following is the most likely reason for the temporary mydriasis observed with topical steroid administration?

Which of the following statements about steroid bioavailability is correct?

Which of the following factors primarily determines the anti-inflammatory efficacy of a steroid?

Which of the following steroid formulations is most suitable for the treatment of posterior segment inflammation?

Which of the following properties of steroids contributes to their potential for causing cataracts?

Which of the following statements about steroid formulations is correct?

Which of the following statements about steroid formulations and bioavailability is correct?

Which of the following factors affects the penetration of steroids through the cornea?

Based on the anti-inflammatory efficacy data provided, which steroid formulation has the highest efficacy when the corneal epithelium is intact?

What is the primary difference between lipid-soluble and water-soluble steroid formulations in terms of their ability to penetrate the cornea?

According to the anti-inflammatory efficacy data, which steroid formulation has the lowest efficacy when the corneal epithelium is absent?

Which statement about prednisolone acetate suspension is correct?

Which statement accurately describes the bioavailability of dexamethasone alcohol and dexamethasone phosphate?

Which property distinguishes dexamethasone from prednisolone?

Which statement accurately compares the anti-inflammatory efficacy of lipid-soluble and water-soluble steroid formulations?

Which statement accurately describes the properties of prednisolone sodium phosphate 1% solution?

Which of the following is the primary reason that steroid suspensions are commonly used for ophthalmic formulations?

Which steroid property contributes to its increased affinity for the glucocorticoid receptor?

Why is the phosphate derivative of prednisolone less preferred for treating anterior segment inflammation compared to the acetate derivative?

Which steroid formulation has the greatest anti-inflammatory effect in the presence of an intact corneal epithelium?

How does the presence of an intact corneal epithelium affect the bioavailability of different steroid formulations in the anterior chamber?

Which steroid is considered the exception to being ketone-based?

Which steroid formulation property is associated with greater corneal penetration?

Which steroid formulation has the highest anti-inflammatory efficacy when the corneal epithelium is absent?

How does the presence of inflammation affect the penetration of different steroid formulations into the anterior chamber?

Which steroid formulation has the greatest anti-inflammatory effect compared to the others?

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