Anti-Inflammatory Drugs Ch. 8 Flashcards
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Questions and Answers

What are the 4 categories of anti-inflammatory drugs?

  • Leukotriene inhibitors (correct)
  • Anti-histamines (correct)
  • Corticosteroids (correct)
  • NSAIDS (correct)
  • What is the difference between inflammation and infection?

    Inflammation is a normal reaction of tissues to injury, while infection is caused by invading microorganisms.

    What is inflammation?

    A non-specific response elicited by various stimuli, providing short-term protection.

    List the observable symptoms of inflammation.

    <p>Pain, swelling, heat, loss of function, redness.</p> Signup and view all the answers

    What are the stages of the inflammatory response?

    <ol> <li>Involves WBC and blood vessel changes; 2. Large number of WBC created; 3. Rapid cell division.</li> </ol> Signup and view all the answers

    What is the function of anti-inflammatory drugs?

    <p>Prevent or limit tissue and blood vessel responses to injury or invasion.</p> Signup and view all the answers

    What are corticosteroids?

    <p>The most powerful anti-inflammatory drugs that can mask symptoms.</p> Signup and view all the answers

    Corticosteroids function to prevent or limit inflammation by ______.

    <p>slowing or stopping inflammatory mediator production.</p> Signup and view all the answers

    What are the intended responses of corticosteroids?

    <p>Reduce redness, pain, swelling, and increase function at the site of inflammation.</p> Signup and view all the answers

    What are the side effects of corticosteroids?

    <p>Hypertension, acne, insomnia, nervousness, increased blood glucose.</p> Signup and view all the answers

    What are the adverse effects of corticosteroids?

    <p>Adrenal gland atrophy, masking of infection, delayed wound healing.</p> Signup and view all the answers

    What should be checked before and after corticosteroid administration?

    <p>Before: dose, drug name, administration method; After: vital signs, weekly weights.</p> Signup and view all the answers

    What is the main difference between COX-1 and COX-2?

    <p>Cox 1 is primarily beneficial, and Cox 2 is primarily harmful.</p> Signup and view all the answers

    What are the two main categories of cyclooxygenase inhibitors?

    <p>Drugs with anti-inflammatory properties</p> Signup and view all the answers

    What is the function of NSAIDs?

    <p>Prevent or limit tissue and blood vessel responses to injury by slowing the production of inflammatory mediators.</p> Signup and view all the answers

    What are the intended responses when using NSAIDs?

    <p>Reduced redness, pain, swelling, warmth, and increased function.</p> Signup and view all the answers

    What are some side effects and adverse effects of NSAIDs?

    <p>Side effects: bleeding, GI ulcers, retention; Adverse effects: possible kidney damage.</p> Signup and view all the answers

    What are the uses of aspirin?

    <p>Analgesic, antipyretic, anti-inflammatory, and suppression of platelet aggregation.</p> Signup and view all the answers

    What are the adverse effects of aspirin?

    <p>GI bleeding, renal impairment, salicylic acid toxicity.</p> Signup and view all the answers

    What drug interactions are important with aspirin?

    <p>Warfarin, glucocorticoids, alcohol, and ibuprofen.</p> Signup and view all the answers

    Study Notes

    Categories of Anti-inflammatory Drugs

    • Four main categories: Corticosteroids, NSAIDs, Anti-histamines, Leukotriene inhibitors

    Inflammation vs. Infection

    • Inflammation is a normal response of tissues and blood vessels to injury or invasion (e.g., sports injuries, pollen)
    • Infection occurs when microorganisms disturb the normal environment and usually causes inflammation

    What is Inflammation?

    • Non-specific bodily response initiated by infectious agents, ischemia, or physical injury
    • Provides immediate but temporary protection

    Observable Symptoms of Inflammation

    • Key symptoms include pain, swelling, heat, loss of function, and redness

    Stages of Inflammatory Response

    • Initial stage involves white blood cells (WBC) and changes in blood vessels, leading to swelling
    • Increased WBC production and exudate (fluid leakage) in the second stage
    • Final stage includes rapid cell division, new blood vessel growth, and scar tissue formation

    Function of Anti-inflammatory Drugs

    • Aim to prevent or limit responses to injury or invasion, enhancing comfort and minimizing tissue damage

    Corticosteroids

    • Most potent anti-inflammatory drugs but can mask symptoms; careful monitoring required
    • If rapid onset is not achieved, consider using an alternative agent

    Corticosteroids Function, Forms, and Routes

    • Work by reducing all pathways of inflammatory mediator production
    • Administered through various routes: oral, parenteral, inhalation, topical, joint injection, rectal, or eye drops

    Intended Response of Corticosteroids

    • Reduce redness, pain, and swelling at the inflammation site; improve affected area functionality

    Side Effects of Corticosteroids

    • Short term: hypertension, insomnia, acne, increased blood glucose levels
    • Long term: adrenal gland suppression, poorer immune function, delayed wound healing, "Cushingoid" appearance

    Adverse Effects of Corticosteroids

    • Potential adrenal gland atrophy, infection masking, and delayed wound healing with altered infection symptoms

    Corticosteroid Administration

    • Pre-administration checks: confirm dosage, drug name, method of administration, assess for signs of infection, and monitor BP and weight
    • Post-administration monitoring includes checking vital signs and weekly weight tracking
    • Patient education includes the importance of not discontinuing abruptly, taking the drug with food, and avoiding crowded places

    NSAIDs: Cyclooxygenase (COX) 1 vs. COX 2

    • COX 1 promotes beneficial effects like protecting the gastrointestinal tract and maintaining renal function
    • COX 2 is associated with harmful responses such as pain and inflammation

    Classification of Cyclooxygenase Inhibitors

    • Two categories:
      • Drugs with anti-inflammatory properties (NSAIDs including aspirin and selective COX inhibitors like celecoxib)
      • Drugs without anti-inflammatory properties (e.g., acetaminophen)

    Function of NSAIDs

    • Limit tissue and blood vessel responses to injury by inhibiting inflammatory mediator production via COX action

    Intended Responses of NSAIDs

    • Aim to reduce redness, pain, swelling, and fever while enhancing function at the inflammation site

    Side and Adverse Effects of NSAIDs

    • Common side effects include bleeding, GI ulcers, pain, fluid retention, and hypertension
    • Adverse effects can lead to potential kidney damage or allergic reactions

    Aspirin Uses

    • Nonselective COX inhibitor known for analgesic, antipyretic, and anti-inflammatory properties
    • Uses include suppression of platelet aggregation, management of dysmenorrhea, cancer prevention, and potential Alzheimer's prevention

    Aspirin Adverse Effects

    • Can cause GI bleeding, renal impairment, tinnitus (ringing in the ears), and Reye's syndrome
    • Signs of aspirin toxicity include nausea and ringing in the ears

    Aspirin Drug Interactions

    • Increased bleeding risk with warfarin, glucocorticoids, alcohol, and ibuprofen

    Non-Aspirin First Generation NSAIDs

    • Similar to aspirin in inhibiting COX 1 and COX 2 but lead to reversible inhibition effects

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    Description

    Explore important concepts in Chapter 8 about anti-inflammatory drugs with these flashcards. Learn to distinguish between inflammation and infection, and familiarize yourself with the four categories of anti-inflammatory medications. This quiz is perfect for students studying pharmacology or medicine.

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