Podcast Beta
Questions and Answers
What is a first-line therapy for H.Pylori infection?
What is the main adverse effect of magnesium-containing antacids?
Which drug combination is part of an alternative therapy for H.Pylori?
What can happen if a patient takes acid-controlling drugs for more than 6 weeks without relief?
Signup and view all the answers
What is the mechanism of action of antacids?
Signup and view all the answers
Which symptom would suggest a patient likely has Peptic Ulcer Disease (PUD) according to the text?
Signup and view all the answers
Which type of medications end in TIDINE?
Signup and view all the answers
What is a potential side effect of H2 receptor antagonists?
Signup and view all the answers
When should antacid medications be taken in relation to meals?
Signup and view all the answers
Why should Misoprostol not be given to women of childbearing age?
Signup and view all the answers
Which drug category is Tums classified under?
Signup and view all the answers
What is the purpose of Simethicone?
Signup and view all the answers
Which acid-controlling drug is least likely to cause constipation as an adverse effect?
Signup and view all the answers
In patients with renal disease, which acid-controlling drug should be avoided?
Signup and view all the answers
What is a potential side effect of H2 receptor antagonists seen in elderly patients specifically mentioned in the text?
Signup and view all the answers
Which type of acid-controlling drug is known to end in 'PRAZOLE'?
Signup and view all the answers
What is a potential adverse effect of calcium-containing acid-controlling drugs?
Signup and view all the answers
Which bacterium is found in the GI tract of most patients with duodenal ulcers according to the text?
Signup and view all the answers
What is the primary enzyme responsible for the digestion of the GI mucosa in Peptic Ulcer Disease (PUD)?
Signup and view all the answers
Which of the following adverse effects is associated with aluminum-containing antacids?
Signup and view all the answers
Which type of acid-controlling drug should be avoided in individuals with renal disease?
Signup and view all the answers
What is a potential adverse effect of taking proton pump inhibitors (PPIs)?
Signup and view all the answers
Which category of medications coats and protects the stomach lining?
Signup and view all the answers
What is a side effect associated with calcium salts?
Signup and view all the answers
What is the significance of testing for H. Pylori in patients with PUD?
Signup and view all the answers
Find the best answer. Which type of acid-controlling drug may lead to premature dissolving of enteric-coated medications?
Signup and view all the answers
What adverse effects are associated with PPIs according to the text?
Signup and view all the answers
What do H2 receptor antagonists aim to do?
Signup and view all the answers
What do PPI's do?
Signup and view all the answers
Antacids......
Signup and view all the answers
With this medication you may see increased gastric acid recreation (hyperacidity rebound) in long term use
Signup and view all the answers
Study Notes
Peptic Ulcer Disease
- Peptic ulcer disease involves digestion of the GI mucosa by the enzyme pepsin.
- H. Pylori bacterium is found in the GI tract of 90% of patients with duodenal ulcers and 70% of gastric ulcers.
- Testing for H. Pylori is essential when a patient presents with PUD.
Treatment of H. Pylori
- First-line therapy includes a 10-14 day course of a PPI, clarithromycin, and either amoxicillin or metronidazole.
- Alternative therapy includes a PPI, bismuth subsalicylate, and the antibiotics tetracycline and metronidazole.
Acid-Controlling Drugs
- Types of acid-controlling drugs include antacids, H2 antagonists, and PPIs.
- Antacids buffer or neutralize stomach acid.
Antacids
- Aluminum salts:
- Aluminum carbonate: Basaljel
- Hydroxide salt: AlternaGEL
- Combination (Aluminum and Magnesium): Gaviscon, Maalox, Mylanta, Di-Gel
- Magnesium salts:
- Magnesium hydroxide
- Gaviscon
- Maalox, Mylanta
- Adverse effects of antacids:
- Aluminum: constipation
- Magnesium: diarrhea
- Calcium: kidney stones, constipation, and rebound hyperacidity
- Calcium carbonate: gas and belching often combined with simethicone
H2 Receptor Antagonists
- H2 receptor antagonists reduce acid production and end in "tidine."
- Adverse effects of H2 receptor antagonists include gynecomastia and confusion in elderly patients.
Proton Pump Inhibitors (PPIs)
- PPIs block acid production in the lumen of the stomach and end in "prazole."
- Adverse effects of PPIs include C. diff, osteoporosis, fractures, and pneumonia.
Miscellaneous Acid-Controlling Drugs
- Miscellaneous acid-controlling drugs protect and coat the stomach lining.
- Examples include misoprostol and simethicone.
- Misoprostol should not be given to women of childbearing age due to the risk of miscarriage.
- Simethicone is an antiflatulence used to reduce gas.
Important Notes
- Antacids may cause premature dissolving of enteric-coated medications, resulting in upset stomach.
- Take antacid medications 1 hour before or 2 hours after meals.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Explore key information about Peptic Ulcer disease, H.Pylori infection, and the first-line and alternative therapies for treating H.Pylori. Test your knowledge on topics like the involvement of pepsin in gastric ulcers, the prevalence of H.Pylori in different types of ulcers, and the recommended medication regimens.
