Podcast
Questions and Answers
What is a first-line therapy for H.Pylori infection?
What is a first-line therapy for H.Pylori infection?
What is the main adverse effect of magnesium-containing antacids?
What is the main adverse effect of magnesium-containing antacids?
Which drug combination is part of an alternative therapy for H.Pylori?
Which drug combination is part of an alternative therapy for H.Pylori?
What can happen if a patient takes acid-controlling drugs for more than 6 weeks without relief?
What can happen if a patient takes acid-controlling drugs for more than 6 weeks without relief?
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What is the mechanism of action of antacids?
What is the mechanism of action of antacids?
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Which symptom would suggest a patient likely has Peptic Ulcer Disease (PUD) according to the text?
Which symptom would suggest a patient likely has Peptic Ulcer Disease (PUD) according to the text?
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Which type of medications end in TIDINE?
Which type of medications end in TIDINE?
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What is a potential side effect of H2 receptor antagonists?
What is a potential side effect of H2 receptor antagonists?
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When should antacid medications be taken in relation to meals?
When should antacid medications be taken in relation to meals?
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Why should Misoprostol not be given to women of childbearing age?
Why should Misoprostol not be given to women of childbearing age?
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Which drug category is Tums classified under?
Which drug category is Tums classified under?
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What is the purpose of Simethicone?
What is the purpose of Simethicone?
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Which acid-controlling drug is least likely to cause constipation as an adverse effect?
Which acid-controlling drug is least likely to cause constipation as an adverse effect?
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In patients with renal disease, which acid-controlling drug should be avoided?
In patients with renal disease, which acid-controlling drug should be avoided?
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What is a potential side effect of H2 receptor antagonists seen in elderly patients specifically mentioned in the text?
What is a potential side effect of H2 receptor antagonists seen in elderly patients specifically mentioned in the text?
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Which type of acid-controlling drug is known to end in 'PRAZOLE'?
Which type of acid-controlling drug is known to end in 'PRAZOLE'?
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What is a potential adverse effect of calcium-containing acid-controlling drugs?
What is a potential adverse effect of calcium-containing acid-controlling drugs?
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Which bacterium is found in the GI tract of most patients with duodenal ulcers according to the text?
Which bacterium is found in the GI tract of most patients with duodenal ulcers according to the text?
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What is the primary enzyme responsible for the digestion of the GI mucosa in Peptic Ulcer Disease (PUD)?
What is the primary enzyme responsible for the digestion of the GI mucosa in Peptic Ulcer Disease (PUD)?
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Which of the following adverse effects is associated with aluminum-containing antacids?
Which of the following adverse effects is associated with aluminum-containing antacids?
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Which type of acid-controlling drug should be avoided in individuals with renal disease?
Which type of acid-controlling drug should be avoided in individuals with renal disease?
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What is a potential adverse effect of taking proton pump inhibitors (PPIs)?
What is a potential adverse effect of taking proton pump inhibitors (PPIs)?
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Which category of medications coats and protects the stomach lining?
Which category of medications coats and protects the stomach lining?
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What is a side effect associated with calcium salts?
What is a side effect associated with calcium salts?
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What is the significance of testing for H. Pylori in patients with PUD?
What is the significance of testing for H. Pylori in patients with PUD?
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Find the best answer. Which type of acid-controlling drug may lead to premature dissolving of enteric-coated medications?
Find the best answer. Which type of acid-controlling drug may lead to premature dissolving of enteric-coated medications?
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What adverse effects are associated with PPIs according to the text?
What adverse effects are associated with PPIs according to the text?
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What do H2 receptor antagonists aim to do?
What do H2 receptor antagonists aim to do?
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What do PPI's do?
What do PPI's do?
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Antacids......
Antacids......
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With this medication you may see increased gastric acid recreation (hyperacidity rebound) in long term use
With this medication you may see increased gastric acid recreation (hyperacidity rebound) in long term use
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Study Notes
Peptic Ulcer Disease
- Peptic ulcer disease involves digestion of the GI mucosa by the enzyme pepsin.
- H. Pylori bacterium is found in the GI tract of 90% of patients with duodenal ulcers and 70% of gastric ulcers.
- Testing for H. Pylori is essential when a patient presents with PUD.
Treatment of H. Pylori
- First-line therapy includes a 10-14 day course of a PPI, clarithromycin, and either amoxicillin or metronidazole.
- Alternative therapy includes a PPI, bismuth subsalicylate, and the antibiotics tetracycline and metronidazole.
Acid-Controlling Drugs
- Types of acid-controlling drugs include antacids, H2 antagonists, and PPIs.
- Antacids buffer or neutralize stomach acid.
Antacids
- Aluminum salts:
- Aluminum carbonate: Basaljel
- Hydroxide salt: AlternaGEL
- Combination (Aluminum and Magnesium): Gaviscon, Maalox, Mylanta, Di-Gel
- Magnesium salts:
- Magnesium hydroxide
- Gaviscon
- Maalox, Mylanta
- Adverse effects of antacids:
- Aluminum: constipation
- Magnesium: diarrhea
- Calcium: kidney stones, constipation, and rebound hyperacidity
- Calcium carbonate: gas and belching often combined with simethicone
H2 Receptor Antagonists
- H2 receptor antagonists reduce acid production and end in "tidine."
- Adverse effects of H2 receptor antagonists include gynecomastia and confusion in elderly patients.
Proton Pump Inhibitors (PPIs)
- PPIs block acid production in the lumen of the stomach and end in "prazole."
- Adverse effects of PPIs include C. diff, osteoporosis, fractures, and pneumonia.
Miscellaneous Acid-Controlling Drugs
- Miscellaneous acid-controlling drugs protect and coat the stomach lining.
- Examples include misoprostol and simethicone.
- Misoprostol should not be given to women of childbearing age due to the risk of miscarriage.
- Simethicone is an antiflatulence used to reduce gas.
Important Notes
- Antacids may cause premature dissolving of enteric-coated medications, resulting in upset stomach.
- Take antacid medications 1 hour before or 2 hours after meals.
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Description
Explore key information about Peptic Ulcer disease, H.Pylori infection, and the first-line and alternative therapies for treating H.Pylori. Test your knowledge on topics like the involvement of pepsin in gastric ulcers, the prevalence of H.Pylori in different types of ulcers, and the recommended medication regimens.
