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Peptic Ulcer Disease: Bacterial Enzymes, H.pylori, and NSAIDs

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Peptic Ulcer Disease: Bacterial Enzymes, H.pylori, and NSAIDs

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Questions and Answers

What is one of the common etiologies for gastric mucosal injury?

Reduced mucosal blood flow

Normal gastric acid secretion

Increased mucus and bicarbonate secretion

Chronic corticosteroid use (correct)

Which factor contributes to disrupting mucosal integrity in the stomach?

Increased mucus production

Helicobacter pylori infection (correct)

Enhanced mucosal blood flow

Normal intrinsic epithelial cell defense

How do nonsteroidal anti-inflammatory drugs (NSAIDs) contribute to stress-related mucosal damage (SRMD)?

Through inhibition of prostaglandin synthesis (correct)

By increasing mucus production

By enhancing mucosal blood flow

By decreasing stomach pH

Which protective factor is involved in maintaining gastroduodenal mucosal integrity?

Intrinsic epithelial cell defense Signup and view all the answers

What is the mechanism by which nonselective NSAIDs, including aspirin, cause gastric mucosal damage?

Direct irritation of the gastric epithelium and systemic inhibition of endogenous mucosal PG synthesis Signup and view all the answers

How does the addition of aspirin affect the ulcer-sparing benefit of a selective COX-2 inhibitor?

Reduces the ulcer-sparing benefit and increases ulcer risk Signup and view all the answers

What is the effect of corticosteroids alone on the risk of ulcers and complications?

Does not increase risk of ulcers or complications Signup and view all the answers

Which factor has been linked to an increased risk of peptic ulcer disease, impaired ulcer healing, and ulcer recurrence?

Cigarette smoking Signup and view all the answers

What is the role of HCl in the stomach?

Destroys microorganisms Signup and view all the answers

Which cells release histamine and stimulate HCl secretion in the stomach?

G cells Signup and view all the answers

What inhibits HCl secretion in the body?

Somatostatin Signup and view all the answers

Which substances increase acid secretion through G cells?

Fats and Lipids Signup and view all the answers

How do medications decrease HCl secretion in the body?

Inhibit histamine release Signup and view all the answers

What is the main factor affecting peptic ulcer disease (PUD) risk?

Use of NSAIDs Signup and view all the answers