14 Questions
What is one of the common etiologies for gastric mucosal injury?
Chronic corticosteroid use
Which factor contributes to disrupting mucosal integrity in the stomach?
Helicobacter pylori infection
How do nonsteroidal anti-inflammatory drugs (NSAIDs) contribute to stress-related mucosal damage (SRMD)?
Through inhibition of prostaglandin synthesis
Which protective factor is involved in maintaining gastroduodenal mucosal integrity?
Intrinsic epithelial cell defense
What is the mechanism by which nonselective NSAIDs, including aspirin, cause gastric mucosal damage?
Direct irritation of the gastric epithelium and systemic inhibition of endogenous mucosal PG synthesis
How does the addition of aspirin affect the ulcer-sparing benefit of a selective COX-2 inhibitor?
Reduces the ulcer-sparing benefit and increases ulcer risk
What is the effect of corticosteroids alone on the risk of ulcers and complications?
Does not increase risk of ulcers or complications
Which factor has been linked to an increased risk of peptic ulcer disease, impaired ulcer healing, and ulcer recurrence?
Cigarette smoking
What is the role of HCl in the stomach?
Destroys microorganisms
Which cells release histamine and stimulate HCl secretion in the stomach?
G cells
What inhibits HCl secretion in the body?
Somatostatin
Which substances increase acid secretion through G cells?
Fats and Lipids
How do medications decrease HCl secretion in the body?
Inhibit histamine release
What is the main factor affecting peptic ulcer disease (PUD) risk?
Use of NSAIDs
Explore the factors contributing to gastric mucosal injury in Peptic Ulcer Disease, including bacterial enzymes like urease, lipases, and proteases, H.pylori virulence factors, bacterial adherence, and the impact of nonselective NSAIDs. Learn how H.pylori alters the host inflammatory response and damages epithelial cells, while NSAIDs cause damage through direct irritation of gastric epithelium.
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