Podcast
Questions and Answers
Which of the following is a potential environmental factor that can contribute to autoimmunity?
Which of the following is a potential environmental factor that can contribute to autoimmunity?
- Genetics
- Inflammation
- Infection (correct)
- Antigens
What is the term used to describe the phenomenon where a viral peptide has similarity to a self peptide?
What is the term used to describe the phenomenon where a viral peptide has similarity to a self peptide?
- Autoimmunity
- Antigen presenting
- Molecular mimicry (correct)
- Inflammation
Which type of immune cell is responsible for presenting the viral peptide to the CD4+ T cell?
Which type of immune cell is responsible for presenting the viral peptide to the CD4+ T cell?
- Antigen presenting cell (correct)
- MHC class T molecule
- CD4+ T cell
- Antiviral CD4+ T cell
What is the potential consequence of an activated CD4+ T cell that has been activated by a self peptide with homology to a viral peptide?
What is the potential consequence of an activated CD4+ T cell that has been activated by a self peptide with homology to a viral peptide?
Which of the following is a key factor in the complexity of molecular mimicry?
Which of the following is a key factor in the complexity of molecular mimicry?
Which autoimmune disease is associated with cross-reactivity between streptococcal antibodies and connective tissue?
Which autoimmune disease is associated with cross-reactivity between streptococcal antibodies and connective tissue?
What is a distinguishing feature of type one diabetes compared to type two diabetes?
What is a distinguishing feature of type one diabetes compared to type two diabetes?
What is the role of genetic susceptibility in the development of diabetes?
What is the role of genetic susceptibility in the development of diabetes?
Which disease is characterized by the presence of immunofluorescence in a chicken wire pattern?
Which disease is characterized by the presence of immunofluorescence in a chicken wire pattern?
Which antibody is targeted in the diagnosis of coeliac disease?
Which antibody is targeted in the diagnosis of coeliac disease?
Which antibody is associated with pernicious anaemia?
Which antibody is associated with pernicious anaemia?
What is the significance of HLA typing in the diagnosis of coeliac disease?
What is the significance of HLA typing in the diagnosis of coeliac disease?
Which method is used to detect autoantibodies in the blood and cerebrospinal fluid?
Which method is used to detect autoantibodies in the blood and cerebrospinal fluid?
What is the advantage of using indirect immunofluorescence to detect antibodies?
What is the advantage of using indirect immunofluorescence to detect antibodies?
What is the purpose of diagnostic autoimmune serology antibodies in autoimmune diseases?
What is the purpose of diagnostic autoimmune serology antibodies in autoimmune diseases?
What is the main reason why indirect immunofluorescence is not commonly used in laboratories?
What is the main reason why indirect immunofluorescence is not commonly used in laboratories?
Which of the following is a possible reason why it is difficult to study the initiation of autoimmune diseases?
Which of the following is a possible reason why it is difficult to study the initiation of autoimmune diseases?
What is a potential mechanism that could link Epstein-Barr virus (EBV) to multiple sclerosis?
What is a potential mechanism that could link Epstein-Barr virus (EBV) to multiple sclerosis?
Which of the following is NOT mentioned as a potential treatment for multiple sclerosis related to Epstein-Barr virus (EBV)?
Which of the following is NOT mentioned as a potential treatment for multiple sclerosis related to Epstein-Barr virus (EBV)?
What factors contribute to the complexity of autoimmune disease development?
What factors contribute to the complexity of autoimmune disease development?
Which method is NOT commonly used in the diagnostic lab anymore?
Which method is NOT commonly used in the diagnostic lab anymore?
What is the main difference between direct and indirect immunofluorescence?
What is the main difference between direct and indirect immunofluorescence?
What is the significance of the thick-walled pearly lesions seen in the top left panel?
What is the significance of the thick-walled pearly lesions seen in the top left panel?
Which disease is characterized by big areas of denuded skin and involvement of mucosal surfaces?
Which disease is characterized by big areas of denuded skin and involvement of mucosal surfaces?
Which of the following is a reason why autoimmune diseases are often treated by managing the consequences rather than using immunosuppression?
Which of the following is a reason why autoimmune diseases are often treated by managing the consequences rather than using immunosuppression?
What makes it difficult to treat autoimmune pancreatitis or autoimmune thyroiditis with immunosuppression?
What makes it difficult to treat autoimmune pancreatitis or autoimmune thyroiditis with immunosuppression?
Why might treating the consequences of an autoimmune disease be preferred over using immunosuppression?
Why might treating the consequences of an autoimmune disease be preferred over using immunosuppression?
What is a potential drawback of using immunosuppressive drugs to treat autoimmune diseases?
What is a potential drawback of using immunosuppressive drugs to treat autoimmune diseases?
What is a possible reason why autoimmune diseases are often subclinical?
What is a possible reason why autoimmune diseases are often subclinical?
How can underactive thyroid be treated?
How can underactive thyroid be treated?
Which of the following is a potential cause of autoimmune hypothyroidism (Hashimoto's thyroiditis)?
Which of the following is a potential cause of autoimmune hypothyroidism (Hashimoto's thyroiditis)?
Which immune cells are primarily responsible for the tissue damage in autoimmune diseases?
Which immune cells are primarily responsible for the tissue damage in autoimmune diseases?
What is the role of T cells in autoimmune responses?
What is the role of T cells in autoimmune responses?
What is the significance of HLA associations in autoimmune diseases?
What is the significance of HLA associations in autoimmune diseases?
Which of the following is a characteristic of peripheral tolerance mechanisms?
Which of the following is a characteristic of peripheral tolerance mechanisms?
Which of the following is an example of an autoimmune disease classified as multi-system?
Which of the following is an example of an autoimmune disease classified as multi-system?
Which type of hypersensitivity is characterized by the presence of autoantibodies that directly cause tissue damage?
Which type of hypersensitivity is characterized by the presence of autoantibodies that directly cause tissue damage?
Which of the following autoimmune diseases is characterized by muscle weakness and fatigability, with eyelids, facial muscles, chewing, talking, and swallowing most often affected?
Which of the following autoimmune diseases is characterized by muscle weakness and fatigability, with eyelids, facial muscles, chewing, talking, and swallowing most often affected?
Which autoimmune disease is associated with a possible link to Coxsackie Virus?
Which autoimmune disease is associated with a possible link to Coxsackie Virus?
What is the potential consequence of an activated CD4+ T cell that has been activated by a self peptide with homology to a viral peptide?
What is the potential consequence of an activated CD4+ T cell that has been activated by a self peptide with homology to a viral peptide?
What is a potential drawback of using immunosuppressive drugs to treat autoimmune diseases?
What is a potential drawback of using immunosuppressive drugs to treat autoimmune diseases?
What is the main reason why indirect immunofluorescence is not commonly used in laboratories?
What is the main reason why indirect immunofluorescence is not commonly used in laboratories?
Which of the following is NOT mentioned as a potential treatment for autoimmune diseases?
Which of the following is NOT mentioned as a potential treatment for autoimmune diseases?
What is the main reason why indirect immunofluorescence is not commonly used in laboratories?
What is the main reason why indirect immunofluorescence is not commonly used in laboratories?
Which of the following is a distinguishing feature of type one diabetes compared to type two diabetes?
Which of the following is a distinguishing feature of type one diabetes compared to type two diabetes?
What is a potential drawback of using immunosuppressive drugs to treat autoimmune diseases?
What is a potential drawback of using immunosuppressive drugs to treat autoimmune diseases?
Which gene is responsible for regulating the ectopic expression of tissue-specific antigens in the thymus?
Which gene is responsible for regulating the ectopic expression of tissue-specific antigens in the thymus?
Which autoimmune disorder is strongly associated with organ-specific autoimmune diseases such as type 1 diabetes, vitiligo, and alopecia?
Which autoimmune disorder is strongly associated with organ-specific autoimmune diseases such as type 1 diabetes, vitiligo, and alopecia?
Which autoimmune disorder is characterized by inflammatory bowel disease, dermatitis, and organ-specific autoimmunity?
Which autoimmune disorder is characterized by inflammatory bowel disease, dermatitis, and organ-specific autoimmunity?
Which HLA molecules are encoded by the HLA system on chromosome 6?
Which HLA molecules are encoded by the HLA system on chromosome 6?
Which method is commonly used to detect autoantibodies in the blood and cerebrospinal fluid?
Which method is commonly used to detect autoantibodies in the blood and cerebrospinal fluid?
What is the main difference between type 1 diabetes and type 2 diabetes?
What is the main difference between type 1 diabetes and type 2 diabetes?
What is the significance of HLA typing in the diagnosis of coeliac disease?
What is the significance of HLA typing in the diagnosis of coeliac disease?
Which disease is characterized by thick-walled bullae on the skin and mucus membranes that rupture easily?
Which disease is characterized by thick-walled bullae on the skin and mucus membranes that rupture easily?
Which of the following is the most accurate description of pernicious anaemia?
Which of the following is the most accurate description of pernicious anaemia?
What is the role of tissue transglutaminase (tTG) in modern immunoassays for coeliac disease?
What is the role of tissue transglutaminase (tTG) in modern immunoassays for coeliac disease?
What is the significance of HLA typing in the diagnosis of coeliac disease?
What is the significance of HLA typing in the diagnosis of coeliac disease?
What is the main reason why treating the consequences of an autoimmune disease may be preferred over using immunosuppression?
What is the main reason why treating the consequences of an autoimmune disease may be preferred over using immunosuppression?
Which of the following is NOT a potential manifestation of vitamin B12 depletion in pernicious anaemia?
Which of the following is NOT a potential manifestation of vitamin B12 depletion in pernicious anaemia?
What is the purpose of plasmapheresis in the treatment of antibody-mediated diseases?
What is the purpose of plasmapheresis in the treatment of antibody-mediated diseases?
