Podcast
Questions and Answers
Which of these bacteria species are associated with periodontal disease?
Which of these bacteria species are associated with periodontal disease?
Which cells are responsible for presenting antigenic parts from pathogens to stimulate B-cell lymphocytes?
Which cells are responsible for presenting antigenic parts from pathogens to stimulate B-cell lymphocytes?
What is the primary function of IgG and IgA antibodies in the immune response?
What is the primary function of IgG and IgA antibodies in the immune response?
Which component do T-Cell receptors engage when responding to antigens?
Which component do T-Cell receptors engage when responding to antigens?
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What role do cytokines play in periodontal disease?
What role do cytokines play in periodontal disease?
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Which type of cytokines are known to promote inflammation in periodontitis?
Which type of cytokines are known to promote inflammation in periodontitis?
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What is the action of matrix metalloproteinases (MMPs) in periodontal disease?
What is the action of matrix metalloproteinases (MMPs) in periodontal disease?
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Which of the following factors can disturb the dynamic equilibrium leading to periodontitis?
Which of the following factors can disturb the dynamic equilibrium leading to periodontitis?
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Which statement is true regarding the role of bacteria in periodontal disease?
Which statement is true regarding the role of bacteria in periodontal disease?
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What is periodontitis?
What is periodontitis?
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Which of the following correctly describes plaque biofilm?
Which of the following correctly describes plaque biofilm?
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Which of the following components is NOT part of the dental plaque biofilm?
Which of the following components is NOT part of the dental plaque biofilm?
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What is one of the stages in the formation of dental plaque biofilm?
What is one of the stages in the formation of dental plaque biofilm?
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Which of the following is NOT a role of cytokines in the host response?
Which of the following is NOT a role of cytokines in the host response?
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Which bacterial feature is associated with the pathogenesis of periodontal disease?
Which bacterial feature is associated with the pathogenesis of periodontal disease?
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Which part of the gingival epithelium is present at the outermost layer of the gingival tissue?
Which part of the gingival epithelium is present at the outermost layer of the gingival tissue?
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What type of immune responses are activated in the oral cavity to defend against periodontal disease?
What type of immune responses are activated in the oral cavity to defend against periodontal disease?
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Flashcards
Subgingival Bacteria
Subgingival Bacteria
Mainly anaerobic bacteria found below the gum line.
Virulence Factors
Virulence Factors
Characteristics of bacteria that enable them to invade and damage tissues.
Innate Immune Response
Innate Immune Response
The body's first line of defense against pathogens, initiated quickly.
Inflammatory Response
Inflammatory Response
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Protective Role of Epithelium
Protective Role of Epithelium
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Junctional Epithelium Cells
Junctional Epithelium Cells
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Saliva Function
Saliva Function
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Adaptive Immune Response
Adaptive Immune Response
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Periodontitis
Periodontitis
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Plaque Biofilm
Plaque Biofilm
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Stages of Biofilm Formation
Stages of Biofilm Formation
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Gingival Epithelium
Gingival Epithelium
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Acquired Immune Response
Acquired Immune Response
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Cytokines
Cytokines
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Epithelial Langerhans' cells
Epithelial Langerhans' cells
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B-cell lymphocytes
B-cell lymphocytes
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Antibody IgG
Antibody IgG
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Prostaglandins
Prostaglandins
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Matrix metalloproteinases (MMPs)
Matrix metalloproteinases (MMPs)
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Clonal expansion
Clonal expansion
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T-cell receptors
T-cell receptors
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Study Notes
Pathogenesis of Periodontal Disease 1
- The session is designed for self-directed learning, using provided resources.
- Key tasks include completing notes to prepare for the next session.
- Resources for review include: development of oral mucosa, junctional epithelium, immunology, dental plaque biofilm, virulence factors, and periodontal disease microbiology.
- Host Defences PDF is also a required resource.
- Learning objectives are to define periodontitis and the role of plaque biofilm, recall tissues in the periodontium, list bacteria types and virulence factors in pathogenesis of periodontal disease, outline host defenses, describe cytokine actions, and describe factors contributing to periodontal initiation.
Defining Periodontitis
- Periodontitis is a periodontal disease.
Plaque Biofilm
- Plaque biofilm is developed in stages.
- Initially, bacteria attach to a pellicle.
- Next, there's initial colonization by bacteria.
- The biofilm composition includes organic and inorganic components, within intra-cellular matrix.
Stages in Plaque Biofilm Formation
- The four stages of plaque biofilm formation include:
- Initial attachment of bacteria to pellicle.
- Initial colonization of the tooth surface (new bacteria joining).
- Intermediate stages (not specified).
- More mature stages (not specified).
Tissues of the Periodontium
- There are three distinct parts found in gingival epithelium. Details are unspecified.
- A diagram of the periodontium shows the various tissues, but specific labeling is lacking.
Bacteria in Periodontitis
- Subgingival environments mostly contain anaerobic bacteria.
- Three bacterial species associated with periodontal disease are listed but unspecified.
- Virulence factors of identified bacteria allow colonization, invasion, and damage of the periodontium. These are not detailed.
Host Defences
- Innate (first) and acquired immune responses are initiated by plaque.
- Key components and functions of the inflammatory response and their roles in periodontal disease are not specified.
- Epithelium's role in defending against plaque microorganisms is unspecified.
Saliva
- Saliva has a role in maintaining oral health. Precise function is unspecified.
Adaptive Immune Response
- Adaptive/Acquired immunity kicks in if innate immunity is ineffective.
- This is highly specific to particular pathogens through recognizing antigens.
- Two main mechanisms of adaptive immunity are humoral (antibody-production) and cell-mediated (cellular response).
- Humoral immunity is when antibodies target antigens circulating extracellularly.
- Detailed components of humoral immunity mechanisms are listed using a table format but unspecified.
Chemical Mediators (Cytokines, Prostaglandins, MMPs)
- Chemical mediators are messengers involved in periodontal disease.
- These link and regulate inflammatory and immune responses and cause tissue damage.
- Different types of mediators and their specific actions/functions in periodontitis are listed in a table, but unspecified.
Factors Contributing to Periodontitis
- Factors disrupting the dynamic equilibrium between plaque and host defenses initiate periodontitis and resulting tissue damage.
- Issues (not detailed)
- Supports (not detailed).
Hypothesis about Bacteria Role in Periodontitis
- Non-specific plaque hypothesis, specific plaque hypothesis, and keystone pathogen-host response hypothesis are outlined, but their detailed issues and supports are not specified.
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Description
This quiz focuses on the pathogenesis of periodontal disease. You'll learn about the development of oral mucosa, the role of plaque biofilm, and the different bacteria types involved. Prepare to define periodontitis, explore host defenses, and understand the immunological aspects of periodontal diseases.