Pathogenesis of Periodontal Disease 1
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Questions and Answers

Which of these bacteria species are associated with periodontal disease?

  • Streptococcus mutans
  • Prevotella intermedia (correct)
  • Porphyromonas gingivalis (correct)
  • Aggregatibacter actinomycetemcomitans (correct)
  • Which cells are responsible for presenting antigenic parts from pathogens to stimulate B-cell lymphocytes?

  • Plasma cells
  • Memory B-cells
  • Cytotoxic T-cells
  • Epithelial Langerhans’ cells (correct)
  • What is the primary function of IgG and IgA antibodies in the immune response?

  • Locally or systemically produced antibody (correct)
  • Stimulate cytokine production
  • Directly kill pathogens
  • Activate T-cells
  • Which component do T-Cell receptors engage when responding to antigens?

    <p>Antigen presenting cells (C)</p> Signup and view all the answers

    What role do cytokines play in periodontal disease?

    <p>They function as chemical mediators that regulate the immune response (B)</p> Signup and view all the answers

    Which type of cytokines are known to promote inflammation in periodontitis?

    <p>Pro-inflammatory cytokines IL-1, IL-6, and TNF-α (B)</p> Signup and view all the answers

    What is the action of matrix metalloproteinases (MMPs) in periodontal disease?

    <p>Degrade extracellular matrix components (B)</p> Signup and view all the answers

    Which of the following factors can disturb the dynamic equilibrium leading to periodontitis?

    <p>Changes in host defenses (C)</p> Signup and view all the answers

    Which statement is true regarding the role of bacteria in periodontal disease?

    <p>Multiple bacterial species contribute to periodontal disease progression (A)</p> Signup and view all the answers

    What is periodontitis?

    <p>A severe form of gum disease affecting the supporting structures of the teeth (D)</p> Signup and view all the answers

    Which of the following correctly describes plaque biofilm?

    <p>A complex aggregation of microorganisms adhering to surfaces (D)</p> Signup and view all the answers

    Which of the following components is NOT part of the dental plaque biofilm?

    <p>Vitamin C (B)</p> Signup and view all the answers

    What is one of the stages in the formation of dental plaque biofilm?

    <p>Initial attachment of bacteria to pellicle (D)</p> Signup and view all the answers

    Which of the following is NOT a role of cytokines in the host response?

    <p>Destroying bacterial cells directly (B)</p> Signup and view all the answers

    Which bacterial feature is associated with the pathogenesis of periodontal disease?

    <p>Virulence factors (A)</p> Signup and view all the answers

    Which part of the gingival epithelium is present at the outermost layer of the gingival tissue?

    <p>Oral epithelium (D)</p> Signup and view all the answers

    What type of immune responses are activated in the oral cavity to defend against periodontal disease?

    <p>Both innate and acquired immune responses (B)</p> Signup and view all the answers

    Flashcards

    Subgingival Bacteria

    Mainly anaerobic bacteria found below the gum line.

    Virulence Factors

    Characteristics of bacteria that enable them to invade and damage tissues.

    Innate Immune Response

    The body's first line of defense against pathogens, initiated quickly.

    Inflammatory Response

    A local response that involves fluid formation and immune cell activation.

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    Protective Role of Epithelium

    The epithelium acts as a barrier against microorganisms.

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    Junctional Epithelium Cells

    Cells that secrete cytokines during inflammation in gingival tissues.

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    Saliva Function

    Role in cleansing the mouth and providing antimicrobial actions.

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    Adaptive Immune Response

    Specific immune response activated when innate immunity fails.

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    Periodontitis

    A serious gum infection damaging the bone and soft tissue.

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    Plaque Biofilm

    A collection of bacteria that adhere to tooth surfaces.

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    Stages of Biofilm Formation

    The process includes attachment, colonization, and maturation of bacteria.

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    Gingival Epithelium

    Three layers of tissue that protect the underlying structures of the gums.

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    Acquired Immune Response

    A specific response developed after exposure to an antigen.

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    Cytokines

    Proteins that mediate and regulate immune responses.

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    Epithelial Langerhans' cells

    Cells that present antigens from pathogens to B-cell lymphocytes stimulating their activation.

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    B-cell lymphocytes

    Immune cells that differentiate into plasma cells which release antibodies against specific antigens.

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    Antibody IgG

    A type of antibody primarily involved in systemic immune responses.

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    Prostaglandins

    Lipids that contribute to inflammation and tissue response in periodontal disease.

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    Matrix metalloproteinases (MMPs)

    Enzymes that break down extracellular matrix components in tissues during inflammation.

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    Clonal expansion

    The process by which B-cells proliferate after recognizing a specific antigen.

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    T-cell receptors

    Molecules found on T-cells that recognize specific antigens presented by other cells.

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    Study Notes

    Pathogenesis of Periodontal Disease 1

    • The session is designed for self-directed learning, using provided resources.
    • Key tasks include completing notes to prepare for the next session.
    • Resources for review include: development of oral mucosa, junctional epithelium, immunology, dental plaque biofilm, virulence factors, and periodontal disease microbiology.
    • Host Defences PDF is also a required resource.
    • Learning objectives are to define periodontitis and the role of plaque biofilm, recall tissues in the periodontium, list bacteria types and virulence factors in pathogenesis of periodontal disease, outline host defenses, describe cytokine actions, and describe factors contributing to periodontal initiation.

    Defining Periodontitis

    • Periodontitis is a periodontal disease.

    Plaque Biofilm

    • Plaque biofilm is developed in stages.
    • Initially, bacteria attach to a pellicle.
    • Next, there's initial colonization by bacteria.
    • The biofilm composition includes organic and inorganic components, within intra-cellular matrix.

    Stages in Plaque Biofilm Formation

    • The four stages of plaque biofilm formation include:
      • Initial attachment of bacteria to pellicle.
      • Initial colonization of the tooth surface (new bacteria joining).
      • Intermediate stages (not specified).
      • More mature stages (not specified).

    Tissues of the Periodontium

    • There are three distinct parts found in gingival epithelium. Details are unspecified.
    • A diagram of the periodontium shows the various tissues, but specific labeling is lacking.

    Bacteria in Periodontitis

    • Subgingival environments mostly contain anaerobic bacteria.
    • Three bacterial species associated with periodontal disease are listed but unspecified.
    • Virulence factors of identified bacteria allow colonization, invasion, and damage of the periodontium. These are not detailed.

    Host Defences

    • Innate (first) and acquired immune responses are initiated by plaque.
    • Key components and functions of the inflammatory response and their roles in periodontal disease are not specified.
    • Epithelium's role in defending against plaque microorganisms is unspecified.

    Saliva

    • Saliva has a role in maintaining oral health. Precise function is unspecified.

    Adaptive Immune Response

    • Adaptive/Acquired immunity kicks in if innate immunity is ineffective.
    • This is highly specific to particular pathogens through recognizing antigens.
    • Two main mechanisms of adaptive immunity are humoral (antibody-production) and cell-mediated (cellular response).
    • Humoral immunity is when antibodies target antigens circulating extracellularly.
    • Detailed components of humoral immunity mechanisms are listed using a table format but unspecified.

    Chemical Mediators (Cytokines, Prostaglandins, MMPs)

    • Chemical mediators are messengers involved in periodontal disease.
    • These link and regulate inflammatory and immune responses and cause tissue damage.
    • Different types of mediators and their specific actions/functions in periodontitis are listed in a table, but unspecified.

    Factors Contributing to Periodontitis

    • Factors disrupting the dynamic equilibrium between plaque and host defenses initiate periodontitis and resulting tissue damage.
    • Issues (not detailed)
    • Supports (not detailed).

    Hypothesis about Bacteria Role in Periodontitis

    • Non-specific plaque hypothesis, specific plaque hypothesis, and keystone pathogen-host response hypothesis are outlined, but their detailed issues and supports are not specified.

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    Description

    This quiz focuses on the pathogenesis of periodontal disease. You'll learn about the development of oral mucosa, the role of plaque biofilm, and the different bacteria types involved. Prepare to define periodontitis, explore host defenses, and understand the immunological aspects of periodontal diseases.

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