PATH30260 - Inflammatory Myopathies & Systemic Vasculitides
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PATH30260 - Inflammatory Myopathies & Systemic Vasculitides

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Questions and Answers

Which type of inflammatory myopathy is typically associated with malignancy?

  • Overlap syndromes
  • Inclusion body myositis
  • Dermatomyositis (correct)
  • Polymyositis

    • Which of the following is a key feature of inclusion body myositis?

  • Presence of autophagic vacuoles and inclusion bodies (correct)
  • Symmetric proximal muscle weakness
  • Responsiveness to immunosuppressive therapy
  • Rapid onset of muscle weakness

    • What is the typical age of onset for inclusion body myositis?

  • Adolescence
  • Over 50 years old (correct)
  • Childhood
  • Middle age

    • Which muscle groups are most commonly affected in inclusion body myositis?

    <p>Finger flexors and knee extensors</p> Signup and view all the answers

    What is the primary immune cell involved in the pathogenesis of inclusion body myositis?

    <p>CD8+ cytotoxic T cells</p> Signup and view all the answers

    Which of the following is a characteristic feature of dermatomyositis?

    <p>Skin rash</p> Signup and view all the answers

    What is the most common skin manifestation of dermatomyositis?

    <p>Rough and cracked palmar and lateral finger areas</p> Signup and view all the answers

    Which of the following is NOT a common systemic symptom of dermatomyositis?

    <p>Raynaud's phenomenon</p> Signup and view all the answers

    What is the main difference between dermatomyositis and polymyositis?

    <p>Dermatomyositis has a rash, while polymyositis does not</p> Signup and view all the answers

    Which autoantibody is highly associated with inflammatory myopathies like dermatomyositis and polymyositis?

    <p>Anti-Jo1 antibodies</p> Signup and view all the answers

    What is the pathogenic mechanism underlying dermatomyositis?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is a common esophageal manifestation of dermatomyositis?

    <p>Dysphagia</p> Signup and view all the answers

    Which of the following is a characteristic of Raynaud's phenomenon?

    <p>The skin turns white or lighter in color as blood flow is restricted</p> Signup and view all the answers

    What is the underlying cause of inflammatory myopathies like dermatomyositis and polymyositis?

    <p>Autoimmune disorder leading to muscle inflammation</p> Signup and view all the answers

    Which of the following is NOT a characteristic of systemic vasculitides?

    <p>Caused by a bacterial infection</p> Signup and view all the answers

    Which of the following skin changes is associated with Raynaud's phenomenon in individuals with dark skin?

    <p>The fingertips may appear paler</p> Signup and view all the answers

    What is the main learning objective of this lecture?

    <p>To understand the etiology and clinical manifestations of inflammatory myopathies and systemic vasculitides</p> Signup and view all the answers

    What is the likely cause of polymyositis in adults?

    <p>Viruses and autoimmune factors</p> Signup and view all the answers

    Which cells are believed to directly injure myocytes in polymyositis?

    <p>CD8+ cytotoxic T cells</p> Signup and view all the answers

    What percentage of polymyositis patients have Anti-Jo1 antibodies?

    <p>20%</p> Signup and view all the answers

    What condition is associated with a poor prognosis in polymyositis?

    <p>Interstitial lung disease</p> Signup and view all the answers

    Which of the following statements about systemic vasculitides is true?

    <p>All of the above</p> Signup and view all the answers

    What is a hallmark feature of Polymyalgia Rheumatica (PMR)?

    <p>Low-grade fever</p> Signup and view all the answers

    Which condition is commonly seen in Asian women and presents with 'Pulseless syndrome' in the upper extremities?

    <p>Takayasu Arteritis</p> Signup and view all the answers

    What treatment is typically effective for patients with PMR?

    <p>Steroids</p> Signup and view all the answers

    Which condition is characterized by segmental transmural necrotizing inflammation of small- to medium-sized arteries?

    <p>Polyarteritis Nodosa</p> Signup and view all the answers

    Which viral infection is associated with Takayasu Arteritis?

    <p>Hepatitis B Virus (HBV)</p> Signup and view all the answers

    What demographic group has a higher prevalence of Polymyalgia Rheumatica?

    <p>Females over 50 years old</p> Signup and view all the answers

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