PATH30260 - Inflammatory Myopathies & Systemic Vasculitides
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Questions and Answers

Which type of inflammatory myopathy is typically associated with malignancy?

  • Overlap syndromes
  • Inclusion body myositis
  • Dermatomyositis (correct)
  • Polymyositis

Which of the following is a key feature of inclusion body myositis?

  • Presence of autophagic vacuoles and inclusion bodies (correct)
  • Symmetric proximal muscle weakness
  • Responsiveness to immunosuppressive therapy
  • Rapid onset of muscle weakness

What is the typical age of onset for inclusion body myositis?

  • Adolescence
  • Over 50 years old (correct)
  • Childhood
  • Middle age

Which muscle groups are most commonly affected in inclusion body myositis?

<p>Finger flexors and knee extensors (D)</p> Signup and view all the answers

What is the primary immune cell involved in the pathogenesis of inclusion body myositis?

<p>CD8+ cytotoxic T cells (B)</p> Signup and view all the answers

Which of the following is a characteristic feature of dermatomyositis?

<p>Skin rash (C)</p> Signup and view all the answers

What is the most common skin manifestation of dermatomyositis?

<p>Rough and cracked palmar and lateral finger areas (C)</p> Signup and view all the answers

Which of the following is NOT a common systemic symptom of dermatomyositis?

<p>Raynaud's phenomenon (D)</p> Signup and view all the answers

What is the main difference between dermatomyositis and polymyositis?

<p>Dermatomyositis has a rash, while polymyositis does not (D)</p> Signup and view all the answers

Which autoantibody is highly associated with inflammatory myopathies like dermatomyositis and polymyositis?

<p>Anti-Jo1 antibodies (D)</p> Signup and view all the answers

What is the pathogenic mechanism underlying dermatomyositis?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is a common esophageal manifestation of dermatomyositis?

<p>Dysphagia (D)</p> Signup and view all the answers

Which of the following is a characteristic of Raynaud's phenomenon?

<p>The skin turns white or lighter in color as blood flow is restricted (B)</p> Signup and view all the answers

What is the underlying cause of inflammatory myopathies like dermatomyositis and polymyositis?

<p>Autoimmune disorder leading to muscle inflammation (C)</p> Signup and view all the answers

Which of the following is NOT a characteristic of systemic vasculitides?

<p>Caused by a bacterial infection (A)</p> Signup and view all the answers

Which of the following skin changes is associated with Raynaud's phenomenon in individuals with dark skin?

<p>The fingertips may appear paler (B)</p> Signup and view all the answers

What is the main learning objective of this lecture?

<p>To understand the etiology and clinical manifestations of inflammatory myopathies and systemic vasculitides (B)</p> Signup and view all the answers

What is the likely cause of polymyositis in adults?

<p>Viruses and autoimmune factors (D)</p> Signup and view all the answers

Which cells are believed to directly injure myocytes in polymyositis?

<p>CD8+ cytotoxic T cells (B)</p> Signup and view all the answers

What percentage of polymyositis patients have Anti-Jo1 antibodies?

<p>20% (A)</p> Signup and view all the answers

What condition is associated with a poor prognosis in polymyositis?

<p>Interstitial lung disease (C)</p> Signup and view all the answers

Which of the following statements about systemic vasculitides is true?

<p>All of the above (D)</p> Signup and view all the answers

What is a hallmark feature of Polymyalgia Rheumatica (PMR)?

<p>Low-grade fever (B)</p> Signup and view all the answers

Which condition is commonly seen in Asian women and presents with 'Pulseless syndrome' in the upper extremities?

<p>Takayasu Arteritis (D)</p> Signup and view all the answers

What treatment is typically effective for patients with PMR?

<p>Steroids (D)</p> Signup and view all the answers

Which condition is characterized by segmental transmural necrotizing inflammation of small- to medium-sized arteries?

<p>Polyarteritis Nodosa (A)</p> Signup and view all the answers

Which viral infection is associated with Takayasu Arteritis?

<p>Hepatitis B Virus (HBV) (D)</p> Signup and view all the answers

What demographic group has a higher prevalence of Polymyalgia Rheumatica?

<p>Females over 50 years old (D)</p> Signup and view all the answers

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