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PATH30260 - Inflammatory Myopathies & Systemic Vasculitides

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Which type of inflammatory myopathy is typically associated with malignancy?

Dermatomyositis

Which of the following is a key feature of inclusion body myositis?

Presence of autophagic vacuoles and inclusion bodies

What is the typical age of onset for inclusion body myositis?

Over 50 years old

Which muscle groups are most commonly affected in inclusion body myositis?

<p>Finger flexors and knee extensors</p> Signup and view all the answers

What is the primary immune cell involved in the pathogenesis of inclusion body myositis?

<p>CD8+ cytotoxic T cells</p> Signup and view all the answers

Which of the following is a characteristic feature of dermatomyositis?

<p>Skin rash</p> Signup and view all the answers

What is the most common skin manifestation of dermatomyositis?

<p>Rough and cracked palmar and lateral finger areas</p> Signup and view all the answers

Which of the following is NOT a common systemic symptom of dermatomyositis?

<p>Raynaud's phenomenon</p> Signup and view all the answers

What is the main difference between dermatomyositis and polymyositis?

<p>Dermatomyositis has a rash, while polymyositis does not</p> Signup and view all the answers

Which autoantibody is highly associated with inflammatory myopathies like dermatomyositis and polymyositis?

<p>Anti-Jo1 antibodies</p> Signup and view all the answers

What is the pathogenic mechanism underlying dermatomyositis?

<p>All of the above</p> Signup and view all the answers

Which of the following is a common esophageal manifestation of dermatomyositis?

<p>Dysphagia</p> Signup and view all the answers

Which of the following is a characteristic of Raynaud's phenomenon?

<p>The skin turns white or lighter in color as blood flow is restricted</p> Signup and view all the answers

What is the underlying cause of inflammatory myopathies like dermatomyositis and polymyositis?

<p>Autoimmune disorder leading to muscle inflammation</p> Signup and view all the answers

Which of the following is NOT a characteristic of systemic vasculitides?

<p>Caused by a bacterial infection</p> Signup and view all the answers

Which of the following skin changes is associated with Raynaud's phenomenon in individuals with dark skin?

<p>The fingertips may appear paler</p> Signup and view all the answers

What is the main learning objective of this lecture?

<p>To understand the etiology and clinical manifestations of inflammatory myopathies and systemic vasculitides</p> Signup and view all the answers

What is the likely cause of polymyositis in adults?

<p>Viruses and autoimmune factors</p> Signup and view all the answers

Which cells are believed to directly injure myocytes in polymyositis?

<p>CD8+ cytotoxic T cells</p> Signup and view all the answers

What percentage of polymyositis patients have Anti-Jo1 antibodies?

<p>20%</p> Signup and view all the answers

What condition is associated with a poor prognosis in polymyositis?

<p>Interstitial lung disease</p> Signup and view all the answers

Which of the following statements about systemic vasculitides is true?

<p>All of the above</p> Signup and view all the answers

What is a hallmark feature of Polymyalgia Rheumatica (PMR)?

<p>Low-grade fever</p> Signup and view all the answers

Which condition is commonly seen in Asian women and presents with 'Pulseless syndrome' in the upper extremities?

<p>Takayasu Arteritis</p> Signup and view all the answers

What treatment is typically effective for patients with PMR?

<p>Steroids</p> Signup and view all the answers

Which condition is characterized by segmental transmural necrotizing inflammation of small- to medium-sized arteries?

<p>Polyarteritis Nodosa</p> Signup and view all the answers

Which viral infection is associated with Takayasu Arteritis?

<p>Hepatitis B Virus (HBV)</p> Signup and view all the answers

What demographic group has a higher prevalence of Polymyalgia Rheumatica?

<p>Females over 50 years old</p> Signup and view all the answers

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