Pain and the Somatosensory System

What does the acronym 'ADME' stand for in pharmacokinetics?

Which of the following is NOT a type of seizure?

What does the term 'therapeutic index' refer to?

What does a black box warning on a drug label signify?

What does the term 'paroxysmal depolarization shift' (PDS) refer to in seizure activity?

What distinguishes chronic pain from acute pain?

Which term refers to increased sensitivity to pain, commonly seen in chronic pain sufferers?

Which of the following accurately describes the nociceptors?

What effect do opioids primarily have on pain modulation?

Which of the following conditions can be associated with neuropathic pain?

Which pharmacological agents are known to modulate the TRPV1 channels involved in pain perception?

What is one limitation of targeting a single nociceptor mechanism for pain management?

Which type of pain pathway is primarily concerned with emotional aspects of pain perception?

Lecture 6 (October 21): Key Study Points

Understand pain's role within the somatosensory system and the difference between acute and chronic pain.
Differentiate neuropathic and inflammatory pain, and recognize relevant conditions (e.g., allodynia, hyperalgesia, spontaneous pain).
Identify factors influencing pain perception beyond typical pain pathways.
Describe the pain pathway, from primary sensory afferents to the cortex, and define nociceptors.
Detail descending pathways and how the rostral ventromedial medulla (RVM) regulates pain.
Outline various pharmacological approaches (e.g., opioids, cannabinoids, antidepressants, NMDA antagonists) to modulate pain, including roles of specific ion channels (NaV1.7 and TRPV1).
Understand limitations of targeting single nociceptor receptors.
Identify examples of anti-inflammatory drugs and their mechanisms of action.
For somatosenses/pain, focus on learning objectives 7.15, 7.16, and 7.17.
Understand pain pathways linked to sensory and emotional components.
Understand opioid-induced analgesia (Figure 7.31). Avoid placebo analgesia and phantom limb pain for now (will be covered later).
Focus on the entire learning objective 16.2 related to Seizure Disorders (chapter 16.1).
Differentiate various seizure types (convulsive and non-convulsive). Identify examples of seizure causes and related pathways.
Understand neuropharmacological aspects, especially excitation, inhibition, and the paroxysmal depolarization shift (PDS).
Summarize interictal periods and current treatment approaches.
Define ADME (in relation to pharmacokinetics).
Describe different drug-administration routes and rationales.
Explain Cmax, Cmin, Tmax, T1/2, and F (bioavailability).
Understand why F% is important in drug efficacy.
Define side effects and their causes, focusing on pharmacovigilance studies.
Understand drug labels and black box warnings.
Evaluate therapeutic indexes and their importance based on disease factors.

This quiz focuses on key concepts from Lecture 6 regarding the role of pain within the somatosensory system. It covers the differences between acute and chronic pain, as well as neuropathic and inflammatory pain. Additionally, the quiz explores pain pathways, nociceptors, and pharmacological approaches to pain modulation.