P450 Drug Interaction Table Quiz

CYP3 A4, 3A5, and 3A7 are all enzymes that can metabolize drugs.

The process of removing a methyl group from a molecule.

The process of breaking down drugs by enzymes in the body.

A table that lists common drug interactions based on the enzymes they affect.

A type of enzyme that plays a major role in drug metabolism.

The study of how drugs interact with the body.

The study of how drugs affect the body.

An enzyme that can metabolize over 50% of all marketed drugs.

A list of drugs that are known to be metabolized by a specific enzyme.

The ability of a drug to interact with another drug, food, or substance.

A group of related enzymes that metabolize various drugs.

A specific CYP450 enzyme involved in the metabolism of drugs like warfarin, theophylline, and some anti-depressants.

Another specific CYP450 enzyme involved in the metabolism of various drugs, such as celecoxib, phenytoin, and others.

A specific CYP450 enzyme involved in the metabolism of various drugs, such as tamoxifen, dextromethorphan, and some anti-depressants.

This table categorizes various medications according to the CYP450 enzymes that mainly metabolize them.

Medications that are broken down by the same CYP450 enzyme can compete for the same 'processing space'.

A drug can increase or decrease the activity of specific CYP450 enzymes, affecting how other drugs are metabolized.

Drugs that are broken down by a specific cytochrome P450 enzyme.

Drugs that block a specific cytochrome P450 enzyme from functioning.

Drugs that boost a specific cytochrome P450 enzyme's activity.

The enzyme family responsible for metabolizing a large variety of drugs.

A drug known to be metabolized by the CYP1A2 enzyme.

A drug known to inhibit (block) the CYP2D6 enzyme.

A drug known to activate (speed up) the CYP3A4 enzyme.

Knowing the dominant cytochrome P450 enzyme for a drug helps predict potential interactions based on the known inhibitors and activators for that enzyme.

Drugs may be metabolized (broken down) into different products, with altered potency or even new effects.

Some drugs might have their effects reduced if their metabolic breakdown is faster (due to an activator drug).

Some drugs might have their effects increased if their metabolic breakdown is slower (due to an inhibitor drug).

Knowing the main metabolic pathway for a drug is crucial for safe and effective prescribing.

Interactions between drugs can be influenced by the balance of enzyme inhibitors and activators present in the body.

The clinical significance of drug interactions may vary depending on the specific drugs involved and their individual effects.

A group of drugs that are metabolized by the same CYP enzyme. They can interact with each other since they compete for the same enzyme.

A specific enzyme involved in drug metabolism (breaking down drugs in the body). Different enzymes can metabolize different drugs.

This occurs when two medications use the same enzyme to be broken down. One drug may slow down the breakdown of the other.

Knowing the drugs listed in the Flockhart Table and which CYP enzymes they interact with can help doctors manage potential drug interactions.

A comprehensive list of interactions between drugs, foods, and substances, based on the enzymes that affect them.

A group of enzymes in the liver that break down medications, potentially affecting their effectiveness or leading to drug interactions. They are numbered based on their genetic structure.

Drugs that increase the activity of certain enzymes, leading to faster metabolism of other drugs. This can reduce the effectiveness of drugs or lead to lower than expected levels in the body.

A specific CYP enzyme that metabolizes many drugs, including antidepressants like fluvoxamine and some anti-infectives. Inhibitors of CYP1A2 can cause drug accumulation and potential side effects.

This enzyme is involved in the metabolism of many drugs, including caffeine and some anti-cancer drugs.

This enzyme is responsible for breaking down a variety of drugs, including some antidepressants and anti-anxiety medications.

A major CYP enzyme known to metabolize various drugs like clopidogrel (blood thinner), ticlopidine (blood thinner), and thiotepa (anticancer). Inhibitors can lead to increased blood thinning effects.

A group of enzymes that play a role in metabolizing drugs, including statins (cholesterol-lowering) and some anti-infectives. Inhibiting CYP2C enzymes can lead to higher drug levels and potential side effects.

This enzyme is important for the metabolism of several drugs, such as some antibiotics and anti-inflammatory drugs.

Broccoli, brussel sprouts, char-grilled meat, and other foods containing these compounds can induce 1A2 activity.

A CYP enzyme that metabolizes a broad range of drugs, including proton pump inhibitors (PPIs) used to treat heartburn and some antidepressants. Inhibition can lead to drug accumulation and side effects.

Carbamazepine, efavirenz, nevirapine, phenobarbital, phenytoin, rifampin, and other medications can increase the activity of 2B6, 2C8, 2C9, 2C19, or 2D6.

A key CYP enzyme responsible for metabolizing many common drugs, including antidepressants, antipsychotics, and anti-infectives. Inhibiting CYP2D6 can lead to altered drug levels and possibly adverse effects.

A CYP enzyme primarily involved in metabolizing drugs that are often used to treat pain and infections, such as opioids and antibiotics. Inhibition can lead to elevated drug levels and potential side effects.

Ethanol, HIV antivirals (efavirenz, nevirapine), isoniazid, glucocorticoids, barbiturates, and other medications can induce the activity of 2E1, 3A4, 5, 7.

The interaction between drugs and enzymes can be complex, and it's important to consult with a healthcare provider to manage potential drug interactions.