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Questions and Answers
Which substance is known to induce the enzyme 2A6?
Which substance is known to induce the enzyme 2A6?
Which drug is NOT an inducer of the enzyme 2D6?
Which drug is NOT an inducer of the enzyme 2D6?
Which of the following is categorized as an inducer for the enzyme 2C19?
Which of the following is categorized as an inducer for the enzyme 2C19?
Which food item is recognized as an inducer for the enzyme 1A2?
Which food item is recognized as an inducer for the enzyme 1A2?
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Which of the following drugs is known to induce the enzyme 3A4?
Which of the following drugs is known to induce the enzyme 3A4?
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Which substance is considered an inducer for the enzyme 2B6?
Which substance is considered an inducer for the enzyme 2B6?
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Which of the following drugs induces the enzyme 2C9?
Which of the following drugs induces the enzyme 2C9?
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Which drug is commonly recognized as an inducer of the enzyme 2E1?
Which drug is commonly recognized as an inducer of the enzyme 2E1?
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Which of the following is known to potentially affect the metabolism of drugs?
Which of the following is known to potentially affect the metabolism of drugs?
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Which medication is listed as affecting the levels of phenytoin?
Which medication is listed as affecting the levels of phenytoin?
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What is one of the drugs that St. John's Wort interacts with?
What is one of the drugs that St. John's Wort interacts with?
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Which drug is known to potentially decrease the efficacy of omeprazole?
Which drug is known to potentially decrease the efficacy of omeprazole?
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Which medication might be influenced by the co-administration of pioglitazone?
Which medication might be influenced by the co-administration of pioglitazone?
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Which of the following is an acceptable inhibitor for in vitro experiments targeting 2B6?
Which of the following is an acceptable inhibitor for in vitro experiments targeting 2B6?
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Which of the following inhibitors is classified under the 2E1 category?
Which of the following inhibitors is classified under the 2E1 category?
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Which of the following is not an acceptable inhibitor for 2C8?
Which of the following is not an acceptable inhibitor for 2C8?
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Which medication is preferred for inhibition of 1A2?
Which medication is preferred for inhibition of 1A2?
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Which of the following options is listed as an HIV antiviral that also acts as an inhibitor?
Which of the following options is listed as an HIV antiviral that also acts as an inhibitor?
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Which of these medications is categorized under the 2D6 inhibitors?
Which of these medications is categorized under the 2D6 inhibitors?
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Which drug is not indicated as a preferred inhibitor for 3A4?
Which drug is not indicated as a preferred inhibitor for 3A4?
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Which of the following is an acceptable inhibitor for in vitro experiments under the 2C19 category?
Which of the following is an acceptable inhibitor for in vitro experiments under the 2C19 category?
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Which of the following is a substrate for enzyme 1A2?
Which of the following is a substrate for enzyme 1A2?
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Which drug is a substrate for enzyme 2D6?
Which drug is a substrate for enzyme 2D6?
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Which of the following medications is associated with enzyme 3A4?
Which of the following medications is associated with enzyme 3A4?
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What is a characteristic of Dapsone?
What is a characteristic of Dapsone?
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Which drug is not listed as a substrate for any of the enzymes mentioned?
Which drug is not listed as a substrate for any of the enzymes mentioned?
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Which medication is related to enzyme 2C9?
Which medication is related to enzyme 2C9?
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Which of the following drugs are substrates for enzyme 2C19?
Which of the following drugs are substrates for enzyme 2C19?
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Which drug is associated with enzyme 2B6?
Which drug is associated with enzyme 2B6?
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Which of these drugs is not a substrate for enzyme 2E1?
Which of these drugs is not a substrate for enzyme 2E1?
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Which drug is indicated as a substrate for multiple enzymes including 3A4, 5, 7?
Which drug is indicated as a substrate for multiple enzymes including 3A4, 5, 7?
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What are substrates in the context of cytochrome P450 enzymes?
What are substrates in the context of cytochrome P450 enzymes?
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Which of the following is an example of an inhibitor in drug interactions?
Which of the following is an example of an inhibitor in drug interactions?
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What is the role of activators in drug metabolism?
What is the role of activators in drug metabolism?
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Which enzyme is primarily associated with the metabolism of caffeine?
Which enzyme is primarily associated with the metabolism of caffeine?
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Which of the following drugs is considered a substrate for the 2D6 enzyme?
Which of the following drugs is considered a substrate for the 2D6 enzyme?
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Which drug is an example of a substrate for the 3A4 enzyme?
Which drug is an example of a substrate for the 3A4 enzyme?
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Which of the following best describes the relationship between inhibitors and substrates?
Which of the following best describes the relationship between inhibitors and substrates?
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Which substance is known to inhibit the enzyme 2D6?
Which substance is known to inhibit the enzyme 2D6?
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Which drug is an example of an activator for enzyme metabolism?
Which drug is an example of an activator for enzyme metabolism?
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What is the consequence of using an enzyme inhibitor along with a substrate?
What is the consequence of using an enzyme inhibitor along with a substrate?
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Which medication may cause a significant interaction by acting as a substrate for multiple P450 enzymes?
Which medication may cause a significant interaction by acting as a substrate for multiple P450 enzymes?
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Which enzyme is noted for metabolizing paroxetine?
Which enzyme is noted for metabolizing paroxetine?
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Which of the following classes of drugs are generally affected by cytochrome P450 interactions?
Which of the following classes of drugs are generally affected by cytochrome P450 interactions?
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What is the primary purpose of understanding P450 enzyme interactions in clinical prescribing?
What is the primary purpose of understanding P450 enzyme interactions in clinical prescribing?
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Which of the following is a substrate of the enzyme 2D6?
Which of the following is a substrate of the enzyme 2D6?
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Which drug is a substrate for CYP enzyme 3A4?
Which drug is a substrate for CYP enzyme 3A4?
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Which of the following is not a substrate for CYP2C9?
Which of the following is not a substrate for CYP2C9?
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Which of the following substances is a known inhibitor of HMG CoA reductase?
Which of the following substances is a known inhibitor of HMG CoA reductase?
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Minaprine is classified under which enzyme substrate category?
Minaprine is classified under which enzyme substrate category?
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Which of the following drugs is associated with the 2B6 enzyme?
Which of the following drugs is associated with the 2B6 enzyme?
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Which drug affects steroid 6beta-OH activity?
Which drug affects steroid 6beta-OH activity?
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Which of these is known to inhibit CYP2C8?
Which of these is known to inhibit CYP2C8?
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Which drug is listed among the miscellaneous substrates?
Which drug is listed among the miscellaneous substrates?
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Study Notes
Flockhart Table
- The Flockhart Table is a tool to help understand drug interactions by looking at how drugs are metabolized.
- Substrates are drugs metabolized by an enzyme.
- Inhibitors prevent the enzyme from metabolizing substrates.
- Activators increase the enzyme's ability to metabolize substrates.
P450 Drug Interaction Table
- The table lists drugs categorized by the cytochrome P450 enzyme isoform they are substrates of.
- It provides information about drug interactions based on substrate, inhibitor, and activator properties.
- Drugs are listed by enzyme isoform (e.g., 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4, 5,7).
- The table categorizes the listed drugs as substrates, inhibitors, or activators. For example, caffeine is a substrate for CYP1A2.
- Examples of drug classes include antidepressants, antibiotics, anesthetics, anti-epileptics, etc.
- The table indicates whether a drug is a strong, moderate, or weak inhibitor, and whether it is a preferred or acceptable inhibitor.
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Description
Test your knowledge of the Flockhart Table and P450 enzyme interactions with this quiz. Explore how various drugs are categorized as substrates, inhibitors, or activators and understand their metabolic relationships. Perfect for students and professionals in pharmacology and medicine.
