Exploring Cytochrome P450 Enzymes and Genetic Polymorphism in Drug Metabolism
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Questions and Answers

Which factor is the main focus in pharmacokinetic variability?

  • Polymorphism
  • Variability in drug metabolism (correct)
  • Enzyme activity
  • Genetic make up

Which term refers to the genetic variation or occurrence of different forms among a group of organisms or species?

  • Polymorphism (correct)
  • Genetic make up
  • Variability
  • Enzyme activity

What is the dependency of enzyme activity and availability?

  • Polymorphism
  • Variability in drug metabolism
  • Pharmacokinetic variability
  • Genetic make up (correct)

Which of the following can occur if there is a deficiency of certain enzymes?

<p>Increased plasma concentration of the corresponding drug substrate (B)</p> Signup and view all the answers

What is the potential consequence of increased plasma concentration of a drug substrate?

<p>Decreased drug efficacy (A)</p> Signup and view all the answers

What is the relationship between enzyme deficiency and adverse drug effects?

<p>Enzyme deficiency can increase the incidence of adverse drug effects (D)</p> Signup and view all the answers

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