43 Questions
Which drug promotes relaxation during bladder filling without engaging muscarinic receptors?
Mirabegron
Which drug inhibits calcium-dependent release of acetylcholine, adenosine triphosphate, and substance P in the detrusor muscle?
Vibegron
Which drug can increase blood pressure and should be avoided in patients with renal disease or hypertension?
Mirabegron
Which drug is a substrate of CYP2D6 and CYP3A4 and is a moderate inhibitor of CYP2D6?
Mirabegron
Which drug has the main side effects of dry mouth and constipation and is a CYP2D6 and CYP3A4 Substrate?
Fesoterodine
Which drug achieves detrusor relaxation by activating beta-3-adrenoreceptors, resulting in activation of adenylyl cyclase and formation of cyclic adenosine monophosphate?
Mirabegron
Which drug requires dosage reduction for renal impairment?
Fesoterodine
Which drug inhibits calcium-dependent release of acetylcholine, adenosine triphosphate, and substance P in the detrusor muscle?
Vibegron
Which drug may increase to 50 mg once daily after 4-8 weeks?
Vibegron
Which drugs have been evaluated as non-traditional therapies for OAB?
Venlafaxine and duloxetine
Which drug is the third-line option for OAB?
Vibegron
What is the main reason for the high incidence of dry mouth as a side effect of oxybutynin?
Muscarinic blockade by oxybutynin itself
Which drug has the greatest degree of M3 selectivity and is well-tolerated for overactive bladder?
Darifenacin
What is the primary mechanism of action of oxybutynin?
Blockade of M3 muscarinic receptors
Which medication can intensify the anticholinergic side effects when used in combination with oxybutynin?
Tricyclics
What is the main side effect of darifenacin?
Dry mouth
Which formulation of oxybutynin is considered long-acting?
Transdermal patch
What effect does darifenacin have on the M1 receptors in the brain and M2 receptors in the heart?
No effect
Which factor can alter oxybutynin blood levels?
$CYP3A4$ inhibition or induction
What population is more likely to experience hallucinations and agitation as side effects of oxybutynin?
Pediatric and geriatric populations
Which medication has been reported to have both mydriasis and blurred vision as side effects?
Oxybutynin
What is a common side effect associated with the use of oxybutynin besides dry mouth?
Urinary hesitancy
What is the primary reason for the high incidence of dry mouth as a side effect of oxybutynin?
Muscarinic blockade by oxybutynin itself
Which formulation of oxybutynin is considered long-acting?
Transdermal patch
Which drug has the greatest degree of M3 selectivity with minimal side effects on M1 and M2 receptors?
Darifenacin
What side effect is prominent in the pediatric and geriatric populations when using oxybutynin?
Hallucinations and agitation
Which medication can alter oxybutynin blood levels?
CYP3A4 inhibitors
Which drug can intensify the anticholinergic side effects when used in combination with oxybutynin?
Tricyclics
Which drug promotes relaxation during bladder filling without engaging muscarinic receptors?
Darifenacin
Which drug achieves detrusor relaxation by activating beta-3-adrenoreceptors, resulting in activation of adenylyl cyclase and formation of cyclic adenosine monophosphate?
Darifenacin
What is the main side effect of darifenacin?
Dry mouth
What drug should be avoided in patients with renal disease or hypertension due to its potential to increase blood pressure?
N-desethyloxybutynin
What is the primary mechanism of action of mirabegron?
Promotion of detrusor relaxation by activating beta-3-adrenoreceptors
Which drug can cause prolongation of the QT interval and should be avoided in patients with renal disease or hypertension?
Vibegron
What is the main side effect of trospium?
Dry mouth and constipation
Which drug achieves detrusor relaxation by inhibiting calcium-dependent release of neurotransmitters in the detrusor muscle?
Vibegron
What is the primary reason for avoiding mirabegron in patients with renal disease or hypertension?
Potential QT prolongation and increase in blood pressure
What is the main side effect of fesoterodine?
Dry mouth and constipation
Which drug is a substrate of CYP2D6 and CYP3A4 and is a moderate inhibitor of CYP2D6?
Mirabegron
What is the primary mechanism of action of oxybutynin?
Inhibition of calcium-dependent release of neurotransmitters in the detrusor muscle
What is the main side effect of tolterodine?
Prolongation of the QT interval
What effect does solifenacin have on the QT interval at high doses?
It can cause QT prolongation
Which medication achieves detrusor relaxation by causing flaccid paralysis in the detrusor and reducing bladder pressure?
Vibegron
Test your knowledge of the side effects of Oxybutynin, an anticholinergic medication primarily acting at the M3 muscarinic receptors. Learn about common side effects such as dry mouth, constipation, tachycardia, urinary hesitancy, retention, mydriasis, blurred vision, dry eyes, and potential rare side effects.
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