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4-L2
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4-L2

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Questions and Answers

What is the main purpose of oxidative phosphorylation?

  • Break down glucose molecules
  • Synthesize ATP using the energy from oxidation of NADH and FAD2H (correct)
  • Form high-energy electrons
  • Transfer protons into the mitochondrial matrix
  • Which stage of catabolism is oxidative phosphorylation?

  • Stage 3
  • Stage 4 (correct)
  • Stage 2
  • Stage 1
  • What happens to all C-C bonds by the end of the TCA cycle?

  • They break down into CO2 (correct)
  • They form ATP
  • They remain intact
  • They transfer electrons to oxygen
  • Where does oxidative phosphorylation occur?

    <p>Mitochondrial matrix</p> Signup and view all the answers

    What is the role of NADH and FAD2H in oxidative phosphorylation?

    <p>Transfer high-energy electrons to oxygen for ATP synthesis</p> Signup and view all the answers

    What is the final destination of high-energy electrons from NADH and FAD2H in oxidative phosphorylation?

    <p>ATP synthesis</p> Signup and view all the answers

    What is the primary function of uncoupling proteins (UCPs) in the context of the given information?

    <p>To dissipate the proton motive force (p.m.f.) as heat by allowing protons to cross the inner mitochondrial membrane without passing through the ATP synthase complex</p> Signup and view all the answers

    What is the role of noradrenaline in the context of uncoupling proteins and heat generation?

    <p>Noradrenaline stimulates lipolysis, providing fuel for oxidation, and activates UCP1, allowing protons to dissipate the p.m.f. as heat</p> Signup and view all the answers

    What happens when electron transport is inhibited by substances like carbon monoxide, cyanide, rotenone, or antimycin?

    <p>NADH and FAD2H are unable to be oxidized, preventing the creation of a p.m.f. and the synthesis of ATP, leading to irreversible cell damage</p> Signup and view all the answers

    What is the relationship between the proton motive force (p.m.f.) and ATP synthesis?

    <p>The p.m.f. is required for ATP synthesis by the ATP synthase complex</p> Signup and view all the answers

    What is the primary source of fuel for oxidation in brown adipose tissue, as mentioned in the given information?

    <p>Fatty acids released through lipolysis</p> Signup and view all the answers

    What is the main function of the electron transport chain?

    <p>To generate ATP from ADP and Pi</p> Signup and view all the answers

    Which of the following complexes is not involved in proton translocation?

    <p>Complex II (Succinate-Q reductase)</p> Signup and view all the answers

    What is the Proton Motive Force (PMF)?

    <p>The electrochemical gradient created by proton translocation</p> Signup and view all the answers

    How many ATP molecules are produced from the oxidation of 2 moles of NADH?

    <p>5</p> Signup and view all the answers

    What is the role of uncouplers in mitochondrial respiration?

    <p>To dissipate the Proton Motive Force as heat</p> Signup and view all the answers

    What is the primary function of Uncoupling Protein 1 (UCP1)?

    <p>To facilitate non-shivering thermogenesis in brown adipose tissue</p> Signup and view all the answers

    Which of the following statements about the coupling of electron transport and ATP synthesis is correct?

    <p>They are tightly coupled processes that regulate each other</p> Signup and view all the answers

    What is the primary role of Complex IV (Cytochrome c oxidase) in the electron transport chain?

    <p>To transfer electrons from cytochrome c to oxygen</p> Signup and view all the answers

    What is the function of Uncoupling Protein 2 (UCP2)?

    <p>To be linked to diabetes, obesity, metabolic syndrome, and heart failure</p> Signup and view all the answers

    What is the purpose of the proton translocating complexes in the electron transport chain?

    <p>To pump protons from the mitochondrial matrix to the intermembrane space</p> Signup and view all the answers

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