4-L2

What is the main purpose of oxidative phosphorylation?

Break down glucose molecules
Synthesize ATP using the energy from oxidation of NADH and FAD2H (correct)
Form high-energy electrons
Transfer protons into the mitochondrial matrix

Which stage of catabolism is oxidative phosphorylation?

Stage 3
Stage 4 (correct)
Stage 2
Stage 1

What happens to all C-C bonds by the end of the TCA cycle?

They break down into CO2 (correct)
They form ATP
They remain intact
They transfer electrons to oxygen

Where does oxidative phosphorylation occur?

Mitochondrial matrix (A) Signup and view all the answers

What is the role of NADH and FAD2H in oxidative phosphorylation?

Transfer high-energy electrons to oxygen for ATP synthesis (D) Signup and view all the answers

What is the final destination of high-energy electrons from NADH and FAD2H in oxidative phosphorylation?

ATP synthesis (D) Signup and view all the answers

What is the primary function of uncoupling proteins (UCPs) in the context of the given information?

To dissipate the proton motive force (p.m.f.) as heat by allowing protons to cross the inner mitochondrial membrane without passing through the ATP synthase complex (D) Signup and view all the answers

What is the role of noradrenaline in the context of uncoupling proteins and heat generation?

Noradrenaline stimulates lipolysis, providing fuel for oxidation, and activates UCP1, allowing protons to dissipate the p.m.f. as heat (C) Signup and view all the answers

What happens when electron transport is inhibited by substances like carbon monoxide, cyanide, rotenone, or antimycin?

NADH and FAD2H are unable to be oxidized, preventing the creation of a p.m.f. and the synthesis of ATP, leading to irreversible cell damage (C) Signup and view all the answers

What is the relationship between the proton motive force (p.m.f.) and ATP synthesis?

The p.m.f. is required for ATP synthesis by the ATP synthase complex (A) Signup and view all the answers

What is the primary source of fuel for oxidation in brown adipose tissue, as mentioned in the given information?

Fatty acids released through lipolysis (A) Signup and view all the answers

What is the main function of the electron transport chain?

To generate ATP from ADP and Pi (B) Signup and view all the answers

Which of the following complexes is not involved in proton translocation?

Complex II (Succinate-Q reductase) (A) Signup and view all the answers

What is the Proton Motive Force (PMF)?

The electrochemical gradient created by proton translocation (D) Signup and view all the answers

How many ATP molecules are produced from the oxidation of 2 moles of NADH?

5 (B) Signup and view all the answers

What is the role of uncouplers in mitochondrial respiration?

To dissipate the Proton Motive Force as heat (A) Signup and view all the answers

What is the primary function of Uncoupling Protein 1 (UCP1)?

To facilitate non-shivering thermogenesis in brown adipose tissue (C) Signup and view all the answers

Which of the following statements about the coupling of electron transport and ATP synthesis is correct?

They are tightly coupled processes that regulate each other (A) Signup and view all the answers

What is the primary role of Complex IV (Cytochrome c oxidase) in the electron transport chain?

To transfer electrons from cytochrome c to oxygen (D) Signup and view all the answers

What is the function of Uncoupling Protein 2 (UCP2)?

To be linked to diabetes, obesity, metabolic syndrome, and heart failure (A) Signup and view all the answers

What is the purpose of the proton translocating complexes in the electron transport chain?

To pump protons from the mitochondrial matrix to the intermembrane space (C) Signup and view all the answers