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Questions and Answers
What is the main role of the Malate Aspartate Shuttle in mitochondrial transport systems?
What is the primary function of Uncouplers in electron transport and oxidative phosphorylation?
How do inhibitors like Cyanide affect the electron transport chain (ETC)?
What is the consequence of Oligomycin blocking the proton channel of ATP Synthase?
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In what conditions do ATP yields from glucose differ slightly between liver and muscle?
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What is the impact of diet aid dinitrophenol (DNP) on electron transport and ATP synthesis?
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Study Notes
Mitochondrial Transport Systems
- Phosphate and ATP/ADP translocases provide substrates for ATP synthase and export ATP.
- The Malate Aspartate Shuttle moves electrons from cytosolic NADH to mitochondrial NAD+.
- The Glycerol-3-Phosphate Shuttle transfers electrons from cytosolic NADH to mitochondrial NAD+.
ATP Yield and Regulation
- ATP yields from glucose differ slightly in liver and muscle in aerobic conditions.
- The rate of respiration is dependent on concentrations of substrates and products.
Inhibitors of Electron Transport and ATP Synthesis
- Cyanide blocks electron transport and ATP synthesis.
- Oligomycin blocks the proton channel of ATP Synthase.
- ATP synthesis requires electron transport, and electron transport requires ATP synthesis.
Uncouplers of Electron Transport and ATP Synthesis
- Electron transport and ATP synthesis can be uncoupled.
- Uncoupling occurs in brown fat and allows non-shivering thermogenesis.
- Dinitrophenol (DNP) is a diet aid that uncouples electron transport and ATP synthesis.
- Uncoupling agents allow O2 consumption to occur without ATP synthesis.
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Description
This quiz covers the mitochondrial transport systems for ADP, Pi, and ATP, as well as the Malate Aspartate Shuttle and the Glycerol-3-Phosphate Shuttle in electron transport. Learn about ATP synthase, ATP/ADP translocases, and the transfer of electrons between cytosolic NADH and mitochondrial NAD+.
