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Questions and Answers
Which term describes the irreversible loss of differentiation in cells?
What characterizes neoplasia?
What is desmoplasia in the context of tumors?
Which of the following is a pre-cancerous lesion?
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What constitutes the proliferating part of a neoplasm?
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Carcinoma in situ is characterized by which of the following?
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What does dysplasia primarily involve?
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Which of the following tumors is also known as a scirrhous tumor?
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What does a raised N/C ratio in dysplastic cells indicate?
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In which area is carcinoma in situ commonly seen?
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Study Notes
Neoplasia
- Abnormal, excessive cellular proliferation, uncoordinated growth, persists after evoking stimuli cease.
- An abnormal mass of tissue.
Oncology
- Study of tumor or neoplastic growth.
Differentiation
- Extent to which neoplastic parenchyma resembles normal parent cells (functionally and morphologically).
Anaplasia
- Irreversible loss of differentiation.
Neoplastic Components
- Parenchyma: Proliferating part of neoplasm.
- Stroma: Connective tissue, blood vasculature, lymphatics; supports parenchyma growth.
- Desmoplasia: Excess stromal content in a tumor (Scirrhous Tumor).
Pre-Cancerous Lesions
- Conditions predisposing to subsequent development of cancer.
- Early recognition is crucial for disease management.
- Examples: Carcinoma in Situ, Dysplasia.
Carcinoma In Situ
- Malignant cells confined to epithelium, basement membrane intact.
- Also called intra-epithelial neoplasia (CIN).
- May regress or progress to invasive cancer.
- True neoplasm with malignant features excluding invasiveness.
- Common sites: Uterus, Cervix, Oral Cavity (leukoplakia), Breast (intralobular and intraductal carcinoma).
Dysplasia
- Abnormal differentiation and cell maturity.
- Alteration in adult cells, characterized by variations in size, shape, and organization.
- Loss of cell uniformity and structural orientation.
- Principally encountered in epithelium.
Dysplastic Cells
- Pleomorphism: Variation in size and shape of cells.
- Raised N/C Ratio: Increased nuclear size compared to cell (normal 1:4 to 6 becomes 1:1).
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Description
Test your knowledge on neoplasia and its components, including differentiation, anaplasia, and pre-cancerous lesions. This quiz covers essential concepts in oncology that are crucial for understanding tumor progression and management.
